發(fā)布時間：2018-06-03 06:29

  本文選題：膝關(guān)節(jié) + 軟骨　； 參考：《浙江大學(xué)》2017年碩士論文

【摘要】：目的探討基質(zhì)誘導(dǎo)的自體軟骨細(xì)胞移植技術(shù)治療膝關(guān)節(jié)軟骨缺損的早期療效。方法分析23名(24膝)采用基質(zhì)誘導(dǎo)的自體軟骨細(xì)胞移植技術(shù)治療的膝關(guān)節(jié)軟骨缺損患者,平均隨訪31個月(6～48個月)。術(shù)前及術(shù)后1、3、6、12、24、36、48個月進(jìn)行國際膝關(guān)節(jié)文獻(xiàn)委員會(International Knee Documentation Committee,IKDC)評分、Lysholm主觀膝關(guān)節(jié)評分;術(shù)前及術(shù)后3、6、12及24個月進(jìn)行膝關(guān)節(jié)MRI檢查,并測量各時間點(diǎn)移植區(qū)與正常區(qū)T2值。結(jié)果21名患者(22膝)獲得臨床隨訪,術(shù)前IKDC評分為(59.6±14.3)分,術(shù)后 1、2、3、4 年分別為(74.2±13.2)、(78.4±10.0)、(78.6±5.9)分和(88.4±10.2)分,較術(shù)前有明顯提高,差異有統(tǒng)計學(xué)意義;術(shù)前Lysholm評分為(66.9±15.6)分,術(shù)后 1、2、3、4 年分別為(87.2±9.3)分、(88.2±8.1)分、(89.8±5.3)分和(95.3±5.8)分,較術(shù)前有明顯提高,差異有統(tǒng)計學(xué)意義。11名患者(12膝)獲得MRI隨訪,術(shù)后1年、2年時移植區(qū)軟骨與正常軟骨的T2值無明顯差異。結(jié)論在年輕的膝關(guān)節(jié)軟骨缺損患者中,基質(zhì)誘導(dǎo)的自體軟骨細(xì)胞移植技術(shù)具有良好的早期療效。
[Abstract]:Objective to investigate the early effect of matrix-induced autologous chondrocyte transplantation in the treatment of cartilage defect of knee joint. Methods Twenty-three patients with articular cartilage defects were treated with matrix induced autologous chondrocyte transplantation. The average follow-up was 31 months to 48 months. Before and 1 month after operation, the International Knee Documentation Committee (ISCC) score and the subjective knee joint score were evaluated by the International Knee Documentation Committee for 48 months, and the knee joint MRI was performed at 612 and 24 months before and after the operation, and the T 2 values of the transplanted and normal areas were measured at each time point. Results the IKDC scores were 59.6 鹵14.3 before operation, 78.4 鹵10.0 鹵10.0 鹵78.6 鹵5.9and 78.4 鹵10.0 for 4 years after operation, respectively, which were significantly higher than those before operation (P < 0.05). The preoperative Lysholm score was 66.9 鹵15.6). The MRI scores were 87.2 鹵9.3 and 89.8 鹵5.3 鹵5.3 鹵5.3 鹵5.3 respectively in 4 years after operation, which were significantly higher than those before operation. The difference was statistically significant. 11 patients with 12 knees were followed up by MRI. There was no significant difference between the T 2 values of cartilage grafts and normal cartilage at 1 year and 2 years after operation. Conclusion Matrix-induced autologous chondrocyte transplantation has a good early effect in young patients with cartilage defect of knee joint.
【學(xué)位授予單位】：浙江大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R687.3

【參考文獻(xiàn)】

相關(guān)期刊論文 前1條

1 王慶;黃華揚(yáng);張濤;鄭小飛;李憑躍;沈洪園;陳加榮;;基質(zhì)誘導(dǎo)自體軟骨細(xì)胞移植修復(fù)膝關(guān)節(jié)軟骨損傷的早期療效[J];中華骨科雜志;2016年01期

，

本文編號：1971823