本文選題：易筋經(jīng) + 退行性膝關(guān)節(jié)炎��； 參考：《湖南中醫(yī)藥大學(xué)》2015年碩士論文

【摘要】：目的：通過觀察易筋經(jīng)鍛煉對退行性膝關(guān)節(jié)炎肝腎虧虛證患者中醫(yī)證候積分、臨床綜合療效、膝關(guān)節(jié)屈曲度、疼痛程度以及C反應(yīng)蛋白(CRP)、白細(xì)胞介素-1(IL-1)的影響,探討易筋經(jīng)鍛煉對退行性膝關(guān)節(jié)炎肝腎虧虛證的臨床療效及作用機(jī)理,從而為易筋經(jīng)的臨床推廣和應(yīng)用提供一定的臨床及理論基礎(chǔ)。 方法：將符合納入標(biāo)準(zhǔn)的90例退行性膝關(guān)節(jié)炎肝腎虧虛證患者按照隨機(jī)數(shù)字表法,隨機(jī)分為易筋經(jīng)加艾灸組(A組)、艾灸組(B組)和易筋經(jīng)組(C組),每組各30例,A組給予易筋經(jīng)鍛煉加艾灸療法,B組給予艾灸療法,C組給予易筋經(jīng)鍛煉療法,觀察三組治療前、1個月后、2個月后退行性膝關(guān)節(jié)炎肝腎虧虛證患者中醫(yī)證候積分、臨床綜合療效、膝關(guān)節(jié)屈曲度、疼痛程度以及應(yīng)用免疫比濁法檢測90例退行性膝關(guān)節(jié)炎肝腎虧虛證患者CRP水平,用ELISA法檢測其IL-1水平的變化,將三組治療前后的觀察指標(biāo)加以對比。 結(jié)果： 1.三組治療后中醫(yī)證候積分、臨床綜合療效都得到改善(P0.05),其中A組療效顯著(P0.01),A組臨床療效優(yōu)于B、C組(P0.05)。B組與C組之間比較無差異性(P0.05)。 2.三組治療后膝關(guān)節(jié)屈曲度,都得到改善(P0.05),其中A組作用顯著(P0.01),B、C兩組作用次之。在治療1個月后,B、C兩組作用相當(dāng)(P0.05),治療2個月后,C組較B組效果好(P0.05)。 3.三組治療后膝關(guān)節(jié)疼痛程度,都得到改善(P0.05),其中A組作用顯著(P0.01),B、C兩組作用次之。在治療1個月后,B、C兩組作用相當(dāng)(P0.05),治療2個月后,B組較C組效果好(P0.05)。 4.三組治療后CRP、IL-1水平都得到改善(P0.05)。A組作用顯著(P0.01),B、C兩組作用次之。在治療后1個月后,B、C兩組作用相當(dāng)(P0.05),治療2個月后,B組較C組效果好(P0.05)。 結(jié)論： 1.易筋經(jīng)鍛煉能改善退行性膝關(guān)節(jié)炎肝腎虧虛證患者膝關(guān)節(jié)功能,提高生活質(zhì)量,尤其是改善膝關(guān)節(jié)屈伸不利癥狀。 2.CRP、IL-1水平與退行性膝關(guān)節(jié)炎病情活動性呈正相關(guān)性。易筋經(jīng)鍛煉能降低退行性膝關(guān)節(jié)炎肝腎虧虛證患者CRP、IL-1水平。 3.易筋經(jīng)鍛煉對退行性膝關(guān)節(jié)炎肝腎虧虛證患者無明顯不良反應(yīng)。 4.易筋經(jīng)鍛煉和艾灸改善退行性膝關(guān)節(jié)炎作用具有協(xié)同性,可以在臨床上聯(lián)合應(yīng)用于治療退行性膝關(guān)節(jié)炎肝腎虧虛證。 5.長期堅(jiān)持每天一次易筋經(jīng)鍛煉,對于維持和改善退行性膝關(guān)節(jié)炎肝腎虧虛證療效有重要意義。
[Abstract]:Objective: to observe the effects of training on the syndromes of traditional Chinese medicine (TCM), clinical comprehensive curative effect, knee flexion, pain degree and C-reactive protein (CRP), interleukin-1 (IL-1) in degenerative knee arthritis patients with deficiency of liver and kidney. To explore the clinical curative effect and mechanism of degenerative knee arthritis with deficiency of liver and kidney by the exercise of Yi jin meridian, so as to provide a certain clinical and theoretical basis for the clinical popularization and application of Yi Jin Jing. Methods: 90 cases of degenerative knee arthritis with deficiency of liver and kidney were divided into two groups according to random digital table method. They were randomly divided into two groups: group A (group A), group B (moxibustion group) and group C (group C). Each group (30 cases) was treated with moxibustion therapy and moxibustion therapy (group B). Three groups of patients with degenerative arthritis of liver and kidney deficiency syndrome were observed before, 1 month, 2 months after the treatment of TCM syndromes integral, clinical comprehensive efficacy, knee flexion, The degree of pain and the level of CRP in 90 cases of degenerative knee arthritis with deficiency of liver and kidney were detected by using immune turbidimetry. The changes of IL-1 level were detected by ELISA method. The observed indexes before and after treatment were compared among the three groups. Results: 1. After treatment, the integral of TCM syndromes and the comprehensive curative effect of the three groups were all improved (P 0.05). The clinical efficacy of group A was significantly better than that of group B (P 0.05). There was no difference between group B and group C (P 0.05). 2. After treatment, the flexion degree of knee joint was improved in all three groups, and group A was the second group. After 1 month of treatment, the effect of the two groups was equivalent to P0.05A, and after 2 months of treatment, the effect of group C was better than that of group B (P 0.05). 3. The degree of knee joint pain in the three groups was improved after treatment. After 1 month of treatment, the effect of group B was equal to that of group B, and the effect of group B was better than that of group C 2 months after treatment. 4. After treatment, the levels of IL-1 in CRPnI were improved significantly in group A and group A, and the effect of group A was significantly higher than that of group C (P 0.01). After 1 month of treatment, the effect of group B was equal to that of group B, and the effect of group B was better than that of group C 2 months after treatment. Conclusion: 1. It can improve the function of knee joint, improve the quality of life, especially improve the adverse symptoms of knee joint flexion and extension in degenerative knee arthritis patients with deficiency of liver and kidney. 2. There was a positive correlation between the level of IL 1 and the activity of degenerative knee arthritis. Easy tendon exercise can reduce the level of CRPN IL 1 in degenerative knee arthritis patients with deficiency of liver and kidney. 3. There was no obvious adverse reaction in degenerative knee arthritis with deficiency of liver and kidney. 4. The treatment of degenerative knee arthritis by training and moxibustion is synergistic and can be used in clinical treatment of degenerative knee arthritis due to deficiency of liver and kidney. 5. It is important to maintain and improve the effect of deficiency of liver and kidney in degenerative knee arthritis.
【學(xué)位授予單位】：湖南中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R684.3

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