本文選題：彌漫性腦損傷 + 肺部感染��； 參考：《中華醫(yī)院感染學(xué)雜志》2017年10期

【摘要】：目的分析彌漫性腦損傷合并肺部感染患者神經(jīng)損傷及炎癥介質(zhì)因子指標(biāo)的變化,為臨床治療提供指導(dǎo)依據(jù)。方法選取2014年1月-2016年1月醫(yī)院收治的彌漫性腦損傷患者66例為研究對(duì)象,針對(duì)患者的臨床感染情況、炎癥因子指標(biāo)水平、感染病原菌及藥敏情況進(jìn)行統(tǒng)計(jì)分析。結(jié)果 66例彌漫性腦損傷患者中,發(fā)生感染25例,感染率為37.88%;感染患者和非感染患者的神經(jīng)細(xì)絲酸性蛋白、肌酸激酶同工酶和髓鞘堿性蛋白等神經(jīng)損傷指標(biāo)差異無統(tǒng)計(jì)學(xué)意義;感染患者的C-反應(yīng)蛋白(CRP)、白介素-6(IL-6)、白介素-8(IL-8)、腫瘤壞死因子α(TNF-α)、白介素-1(IL-1)水平分別為(40.87±5.34)mg/L、(337.24±23.45)pg/ml、(540.83±46.93)pg/ml、(95.92±8.62)pg/ml和(0.99±0.11)ng/L,均高于非感染患者的(30.82±3.57)mg/L、(259.45±16.83)pg/ml、(469.74±44.83)pg/ml、(84.44±7.45)pg/ml和(0.31±0.01)ng/L,且差異有統(tǒng)計(jì)學(xué)意義(P0.01);25例感染患者共分離出病原菌30株,其中革蘭陰性菌21株、革蘭陽性菌8株、真菌1株,分別占70.00%、26.67%和3.33%;革蘭陰性菌對(duì)氨曲南和亞胺培南的敏感度高,對(duì)氨芐西林、哌拉西林、頭孢噻肟和頭孢曲松等耐藥性高,革蘭陽性菌對(duì)青霉素和慶大霉素的耐藥性高,對(duì)利福平的敏感度高。結(jié)論彌漫性腦損傷合并肺部感染患者的神經(jīng)損傷情況較未感染患者差異不大,但其炎癥因子水平顯著升高,同時(shí)導(dǎo)致患者感染的病原菌以革蘭陰性菌為主,臨床治療應(yīng)根據(jù)藥敏結(jié)果采取敏感的抗菌藥實(shí)施針對(duì)性治療。
[Abstract]:Objective to analyze the changes of nerve injury and inflammatory mediators in patients with diffuse brain injury complicated with pulmonary infection, and to provide guidance for clinical treatment. Methods 66 patients with diffuse brain injury were selected from January 2014 to January 2016. The clinical infection, the level of inflammatory factors, the pathogenic bacteria and the drug sensitivity of the patients were statistically analyzed. Results among 66 patients with diffuse brain injury, 25 cases were infected, the infection rate was 37.88, and there was no significant difference in neurofilament acidic protein, creatine kinase isoenzyme and myelin basic protein between infected patients and non-infected patients. 鎰熸煋鎮(zhèn)ｈ，

本文編號(hào)：1901480