本文選題：脾切除賁周血管離斷術(shù) + 肝硬化��； 參考：《臨床外科雜志》2015年03期

【摘要】：目的探討脾切除賁周血管離斷術(shù)對(duì)慢性乙型肝炎肝硬化門靜脈高壓癥患者肝纖維化指標(biāo)及肝硬化病程的影響和可能機(jī)制。方法選擇20例:HBsAg(+)、HBV-DNA(-)門靜脈高壓癥患者,其中肝功能Child-Pugh A級(jí)14例,Child-Pugh B級(jí)6例。分別于脾切除賁周血管離斷術(shù)前后,采用酶聯(lián)免疫吸附試驗(yàn)(ELISA)法測(cè)定血清基質(zhì)金屬蛋白酶-1(MMP-1)和基質(zhì)金屬蛋白酶組織抑制因子-1(TMP-1);化學(xué)發(fā)光免疫法測(cè)定透明質(zhì)酸(HA)、三型前膠原N端肽(PC-Ⅲ)、四型膠原(Ⅳ-C)、層粘連蛋白(LN)。結(jié)果 (1)血清TIMP-1及肝纖4項(xiàng)指標(biāo)較術(shù)前明顯下降(p0.05),MMP-1較術(shù)前緩慢升高(P0.05)。(2)TIMP-1與肝纖四項(xiàng)指標(biāo)的變化成正相關(guān)關(guān)系(r=0.458~0.783,P0.01/0.05),MMP-1與肝纖4項(xiàng)指標(biāo)的變化呈負(fù)相關(guān)關(guān)系(r=-0.545~-0.873,P0.01/0.05)。結(jié)論脾切除賁周血管離斷術(shù)可使肝纖維化血清學(xué)指標(biāo)和TIMP-1含量下降、MMP-1含量緩慢升高,有利于減緩肝硬化患者的病情進(jìn)展。
[Abstract]:Objective to investigate the effect of splenectomy and pericardial devascularization on hepatic fibrosis and the course of liver cirrhosis in patients with chronic hepatitis B cirrhosis and portal hypertension. Methods Twenty cases of portal hypertension with HBV-DNA were selected, including 14 cases of Child-Pugh A grade of liver function and 6 cases of Child-Pugh B grade. Before and after splenectomy and pericardial devascularization, Serum matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of matrix metalloproteinase-1 (MMP-1) were determined by enzyme linked immunosorbent assay (Elisa), hyaluronic acid Ham, type 3 procollagen N-terminal peptide PC- 鈪，

本文編號(hào)：1898670