本文選題：自擬活血通脈湯 + 外科手術(shù)�。� 參考：《遼寧中醫(yī)雜志》2017年06期

【摘要】：目的:觀察自擬活血通脈湯聯(lián)合外科手術(shù)對單純性下肢淺靜脈曲張患者氧化-抗氧化系統(tǒng)及血液流變學(xué)的影響。方法:將106例單純性下肢淺靜脈曲張患者隨機分為觀察組(n=53例)和對照組(n=53例),對照組給予外科手術(shù)治療,觀察組在對照組治療基礎(chǔ)上術(shù)后給予自擬活血通脈湯治療,療程為4周;觀察兩組治術(shù)后皮下血腫、硬結(jié)、瘀斑及患肢麻木疼痛等并發(fā)癥的發(fā)生情況;觀察兩組治療前后靜脈疾病臨床嚴(yán)重程度評分(RVCSS評分)、靜脈功能不全生活質(zhì)量問卷中的VEINES-Sym評分及VEINES-QOL評分、洪堡靜脈曲張嚴(yán)重程度評分(HVVSS評分)變化情況;檢測兩組治療前后氧化-抗氧化系統(tǒng)及血液流變學(xué)相關(guān)指標(biāo)。結(jié)果:觀察組治療后2周、4周的皮下血腫、硬結(jié)、瘀斑及患肢麻木疼痛發(fā)生率低于對照組(均P0.05);兩組治療后2周、4周的RVCSS評分、VEINES-Sym評分、VEINES-QOL評分、HVVSS評分均有改善,觀察組上述評分的改善情況優(yōu)于對照組(均P0.05);觀察組治療后2周、4周的臨床療效優(yōu)于對照組(均P0.05);兩組治療后過氧化氫酶(CAT)、超氧化物歧化酶(SOD)、谷胱甘肽過氧化物酶(GSH-PX)升高,丙二醛(MDA)水平降低,觀察組上述指標(biāo)改善情況優(yōu)于對照組(均P0.05);觀察組治療后全血黏度(低、中、高切)、血漿黏度及紅細胞比積均有低于對照組(均P0.05)。結(jié)論:外科手術(shù)治療單純性下肢淺靜脈曲張的基礎(chǔ)上,采用自擬活血通脈湯治療能夠降低術(shù)后并發(fā)癥,并改善患者癥狀,提高療效及生活質(zhì)量,抑制氧化應(yīng)激反應(yīng)并改善血液流變學(xué),從而促進患者康復(fù)。
[Abstract]:Objective: to observe the effect of Huoxue Tongmai decoction combined with surgery on oxidation-antioxidation system and hemorheology in patients with simple superficial varices of lower extremity. Methods: 106 patients with simple superficial varicose veins of lower extremity were randomly divided into two groups: the observation group (n = 53) and the control group (n = 53). The control group received surgical treatment. The observation group was treated with self-made Huoxue Tongmai decoction after operation on the basis of the treatment in the control group. The course of treatment was 4 weeks. The complications such as subcutaneous hematoma, induration, ecchymosis and numbness were observed in the two groups. Before and after treatment, the clinical severity scores of venous diseases, VEINES-Sym scores and VEINES-QOL scores, and Humboldt variceal severity scores were observed. The oxidation-antioxidation system and hemorheology were measured before and after treatment in both groups. Results: the incidence of subcutaneous hematoma, induration, ecchymosis and limb numbness in the observation group was lower than that in the control group 2 weeks after treatment (all P 0.05), the RVCSS score and VEINES-system score and VEINES-QOL score were improved in both groups 2 weeks after treatment and 4 weeks after treatment. The improvement of the above scores in the observation group was better than that in the control group (all P 0.05), the clinical effect in the observation group was better than that in the control group at 2 weeks and 4 weeks after treatment (all P 0.05), and the levels of catalase, superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) in the two groups were increased after treatment. The level of malondialdehyde (MDA) decreased, the improvement of above indexes in the observation group was better than that in the control group (all P 0.05), the whole blood viscosity (low, medium, high shear rate), plasma viscosity and hematocrit in the observation group were lower than those in the control group (all P 0.05). Conclusion: on the basis of surgical treatment of simple superficial varices of lower extremity, self-made Huoxue Tongmai decoction can reduce postoperative complications, improve symptoms, improve curative effect and improve quality of life. Inhibit oxidative stress and improve hemorheology, thus promoting patient recovery.
【作者單位】： 宜昌市中醫(yī)醫(yī)院;
【分類號】：R654.4

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