發(fā)布時間：2018-05-10 10:05

  本文選題：生物相容性材料 + 牙槽突��； 參考：《中國組織工程研究》2017年10期

【摘要】：背景:在骨修復(fù)中,組織工程可以作為一種新的方法取代自體骨移植。其中支架是組織工程技術(shù)的重要元素,而3D打印技術(shù)可以在其制作過程中實現(xiàn)精確的調(diào)控,因此有關(guān)3D打印技術(shù)在支架制作中的應(yīng)用受到越來越多的關(guān)注。目的:對現(xiàn)有關(guān)于3D打印支架應(yīng)用于骨缺損修復(fù)的體外或體內(nèi)研究進(jìn)行回顧,以期為未來的科研及臨床提供新的依據(jù)。方法:由第一作者從Pub Med數(shù)據(jù)庫中,以"tissue engineering;bone;three-dimensional printing;scaffold"為關(guān)鍵詞檢索2003年1月至2016年3月間發(fā)表的文獻(xiàn),篩選出與3D打印組織工程支架相關(guān)的文獻(xiàn)。結(jié)果與結(jié)論:目前已有大量關(guān)于3D打印組織工程支架的研究,支架的材料選擇和表面修飾逐漸成為研究熱點。如今支架材料適當(dāng)?shù)目紫堵室殉蔀樵O(shè)計中必不可少的元素,越來越精細(xì)的加工手法也提升了支架的各項性能,而在材料的選擇上也越來越多的偏向于復(fù)合材料而不是單一的同種材料,這些措施不僅提高了機(jī)械性能,還促進(jìn)了細(xì)胞附著和生長繁殖,最后對于支架的各種促成骨表面處理,更是在細(xì)胞分子水平上促進(jìn)了機(jī)體與植入材料間的互相作用。體內(nèi)外的研究結(jié)果均顯示復(fù)合材料且表面涂布骨誘導(dǎo)涂層均可以不同程度地提高支架性能和促進(jìn)成骨。
[Abstract]:Background: tissue engineering can be used as a new method to replace autogenous bone graft in bone repair. Scaffold is an important element of tissue engineering technology, and 3D printing technology can achieve accurate control in the process of fabrication. Therefore, the application of 3D printing technology in scaffold fabrication has attracted more and more attention. Objective: to review in vitro and in vivo studies on the application of 3D printing scaffolds in bone defect repair in order to provide a new basis for future scientific research and clinical application. Methods: the literature published between January 2003 and March 2016 was searched by the first author from the Pub Med database, using "tissue engineering scaffold" as the key word, and the literatures related to 3D printing tissue engineering scaffold were screened out. Results & conclusion: there have been a lot of researches on 3D printed tissue engineering scaffolds, and the material selection and surface modification of scaffolds have gradually become a hot topic. Nowadays, proper porosity of scaffold materials has become an essential element in design, and more and more sophisticated processing techniques have also improved the properties of scaffolds. And more and more materials are chosen in favor of composite materials rather than the same material, these measures not only improve the mechanical properties, but also promote cell adhesion and growth and reproduction, and finally promote bone surface treatment for various scaffolds. It also promotes the interaction between organism and implant material at cellular and molecular level. The results in vivo and in vitro showed that the composite material and the bone-induced coating on the surface could improve the scaffold properties and promote osteogenesis in varying degrees.
【作者單位】： 上海交通大學(xué)醫(yī)學(xué)院附屬第九人民醫(yī)院口腔正畸科上海市口腔醫(yī)學(xué)重點實驗室;
【基金】：上海市科學(xué)技術(shù)委員會科研計劃項目(124119b0103)~~
【分類號】：R318.08;R683

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