本文選題：香蒲醒神湯 + 高壓氧��； 參考：《中國臨床藥理學(xué)雜志》2016年22期

【摘要】：目的觀察香蒲醒神湯聯(lián)合高壓氧治療重型顱腦損傷后意識障礙的臨床療效。方法 54例重型顱腦損傷后意識障礙患者隨機(jī)分為對照組及試驗(yàn)組,各27例。對照組在常規(guī)治療的基礎(chǔ)上給予高壓氧治療,每次60 min,每天1次,試驗(yàn)組在對照組基礎(chǔ)上加用香蒲醒神湯(以麝香、蒲黃、石菖蒲、冰片等為主的中藥復(fù)方),每次125 m L,每天2次,鼻飼;2組均治療1個月。比較2組患者治療前后血清S100蛋白(S100-B)、髓鞘堿性蛋白(MBP)、神經(jīng)元特異性烯醇化酶(NSE)水平、清醒時間、格拉斯哥預(yù)后評分(GOS)及臨床療效情況。結(jié)果治療后,試驗(yàn)組有效率為77.78%(21/27例),對照組為62.97%(17/27例),差異有統(tǒng)計學(xué)意義(P0.05)。治療后,對照組血清S100-B為(1.06±0.15)μg·L~(-1),MBP為(6.56±0.75)μg·L~(-1),NSE為(12.65±1.53)μg·L~(-1),試驗(yàn)組血清S100-B為(0.54±0.07)μg·L~(-1),MBP為(1.72±0.24)μg·L~(-1),NSE為(6.48±0.92)μg·L~(-1),差異有統(tǒng)計學(xué)意義(P0.05)。對照組患者清醒時間為(24.73±3.52)d,GOS評分為(2.73±0.36)分;試驗(yàn)組患者清醒時間為(15.28±2.16)d,GOS評分為(3.86±0.55)分,差異有統(tǒng)計學(xué)意義(P0.05)。藥物不良反應(yīng)主要表現(xiàn)為煩躁、惡心,2組藥物不良反應(yīng)發(fā)生率差異無統(tǒng)計學(xué)意義(P0.05)。結(jié)論香蒲醒神湯聯(lián)合高壓氧治療能夠顯著降低重型顱腦損傷后意識障礙患者的血清S100-B、MBP及NSE水平,縮短清醒時間,改善患者預(yù)后,有較好的臨床療效,且安全性較高。
[Abstract]:Objective to observe the clinical effect of Huangpu Xingshen decoction combined with hyperbaric oxygen on consciousness disorder after severe craniocerebral injury. Methods 54 patients with severe craniocerebral injury were randomly divided into control group (n = 27) and experimental group (n = 27). The control group was treated with hyperbaric oxygen once a day for 60 minutes on the basis of routine treatment. The experimental group was treated with Typha Xingshen decoction on the basis of the control group. Borneol and other traditional Chinese medicine compound compound, 125 mL per time, twice a day, nasal feeding group 2 were treated for 1 month. The levels of serum S100 protein, myelin basic protein (MBP), neuron-specific enolase (NSE), waking time, Glasgow prognosis score (Glasgow prognosis score) and clinical efficacy were compared before and after treatment. Results after treatment, the effective rate was 77.78 / 21 / 27 in the trial group and 62.97 / 17 / 27 in the control group. The difference was statistically significant (P 0.05). After treatment, the serum S100-B of the control group was 1.06 鹵0.15 渭 g / L, the MBP of the control group was 6.56 鹵0.75) 渭 g / L, the NSE of the control group was 12.65 鹵1.53 渭 g / L, and the serum S100-B of the experimental group was 0.54 鹵0.07) 渭 g / L, the MBP of the control group was 1.72 鹵0.24) 渭 g / L / L of NSE was 6.48 鹵0.92 渭 g / L ~ (-1) (P 0.05). The GOS scores of the patients in the control group were 24.73 鹵3.52 鹵2.73 鹵0.36, and those in the test group were 15.28 鹵2.16 days and 3.86 鹵0.55, respectively. The difference was statistically significant (P 0.05). Adverse drug reactions were mainly dysphoric. There was no significant difference in the incidence of adverse drug reactions between the two groups (P 0.05). Conclusion the combination of Huangpu Xingshen decoction and hyperbaric oxygen therapy can significantly reduce the levels of serum S100-BX MBP and NSE in patients with severe craniocerebral injury, shorten the waking time, improve the prognosis of the patients, and have better clinical efficacy and higher safety.
【作者單位】： 衢州市柯城區(qū)人民醫(yī)院神經(jīng)外科;
【基金】：浙江省中醫(yī)藥科技計劃基金資助項(xiàng)目(2010ZB156)
【分類號】：R651.15

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本文編號：1811745