本文選題：牛心包補(bǔ)片 + 國產(chǎn)補(bǔ)片��； 參考：《復(fù)旦學(xué)報(bào)(醫(yī)學(xué)版)》2017年02期

【摘要】：目的本研究對(duì)國產(chǎn)牛心包補(bǔ)片的安全性和有效性進(jìn)行評(píng)價(jià),為進(jìn)一步臨床應(yīng)用提供實(shí)驗(yàn)基礎(chǔ)。方法采用綿羊肺動(dòng)脈及降主動(dòng)脈補(bǔ)片植入模型,以4只羊作為實(shí)驗(yàn)組,在肺動(dòng)脈干和降主動(dòng)脈干兩處共植入8枚國產(chǎn)牛心包補(bǔ)片;以2只羊作為對(duì)照組,在肺動(dòng)脈干和降主動(dòng)脈干兩處共植入4枚進(jìn)口牛心包補(bǔ)片。術(shù)前對(duì)所有動(dòng)物進(jìn)行常規(guī)生化檢查,術(shù)后第1個(gè)月、第2個(gè)月隨訪超聲心動(dòng)圖,第3個(gè)月時(shí)進(jìn)行取材,比較兩組植入補(bǔ)片的內(nèi)皮化、炎癥和鈣化程度等。結(jié)果 (1)所有動(dòng)物均存活,未發(fā)生手術(shù)相關(guān)并發(fā)癥;(2)超聲心動(dòng)圖第1個(gè)月、第2個(gè)月的結(jié)果顯示肺動(dòng)脈和主動(dòng)脈補(bǔ)片內(nèi)無縫合處漏血、無鈣化、無血栓形成、無贅生物、無明顯動(dòng)脈瘤樣擴(kuò)張;(3)肉眼觀察兩組補(bǔ)片均無內(nèi)膜增生,厚度和韌度較術(shù)前無明顯改變;兩組補(bǔ)片內(nèi)膜光滑,均無肉眼可見的鈣化和異物。(4)微生物學(xué)檢測(cè)提示兩組補(bǔ)片均未出現(xiàn)微生物感染,均有良好的內(nèi)皮化,均有炎癥細(xì)胞浸潤,壞死、鈣化程度差異無顯著統(tǒng)計(jì)學(xué)意義。結(jié)論國產(chǎn)牛心包補(bǔ)片在綿羊肺動(dòng)脈和主動(dòng)脈補(bǔ)片試驗(yàn)中具有良好的安全性和有效性。
[Abstract]:Objective to evaluate the safety and efficacy of domestic bovine pericardial patch in order to provide experimental basis for further clinical application. Methods using sheep pulmonary artery and descending aorta patch implantation model, 4 sheep as experimental group, a total of 8 domestic cattle pericardial patch were implanted in pulmonary artery trunk and descending aortic trunk, and 2 sheep were used as control group. Four imported bovine pericardial patches were implanted in the pulmonary trunk and descending aortic trunk. All animals were examined by routine biochemical examination before operation. Echocardiography was followed up in the first month and the second month after operation. The endothelium inflammation and calcification were compared between the two groups at the third month. Results 1) all the animals survived, and no operative complications occurred. The results of echocardiography at the first month and the second month showed that there was no blood leakage, no calcification, no thrombus, no neoplasm in pulmonary artery and aorta patch. There was no intimal hyperplasia, thickness and toughness of the two groups were not obviously changed compared with those before operation, and the intima of the two groups were smooth and smooth. There was no visible calcification and foreign body. 4) Microbiological examination showed that there was no microbe infection in both groups, and there was no significant difference in inflammatory cell infiltration, necrosis and calcification between the two groups. Conclusion domestic bovine pericardium patch has good safety and efficacy in sheep pulmonary artery and aortic patch test.
【作者單位】： 復(fù)旦大學(xué)附屬中山醫(yī)院心外科;
【基金】：國家自然科學(xué)基金(81501595)~~
【分類號(hào)】：R654.2

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