本文選題：骨腫瘤 + 奇異性骨旁骨軟骨瘤樣增生�。� 參考：《臨床與實驗病理學(xué)雜志》2016年09期

【摘要】：目的探討奇異性骨旁骨軟骨瘤樣增生(bizarre parosteal osteochondromatous proliferation,BPOP)的臨床影像學(xué)和病理組織學(xué)特征、鑒別診斷、治療及預(yù)后。方法對5例BPOP進行HE染色,并進行相關(guān)文獻復(fù)習(xí)。結(jié)果 5例BPOP患者發(fā)病年齡17~48歲,無性別差異,均感覺腫痛不適就診,病變位于四肢長、短管狀骨。X線示寬基底的邊界清晰的高密度腫塊,起源骨膜下完整的骨皮質(zhì),病變部位與附著骨的骨髓腔亦不相通,其中1例伴附骨的骨皮質(zhì)輕度破壞。鏡下見主要由軟骨、骨和纖維組織無規(guī)則排列而成,輕度異型的軟骨細胞可伴大部分鈣化軟骨,即多形性骨小梁中的"藍骨";骨小梁周圍被覆無異型的骨母細胞,骨小梁間有大量的血管、纖維組織增生。結(jié)論 BPOP是一種罕見的、良性的骨軟骨瘤樣病變,術(shù)后高復(fù)發(fā)性,無轉(zhuǎn)移,惡變罕見,需結(jié)合影像學(xué)與病理組織學(xué)特點進行診斷,易誤診,需與骨旁骨肉瘤、軟骨肉瘤、骨化性肌炎等鑒別。
[Abstract]:Objective to investigate the clinical and histopathological features, differential diagnosis, treatment and prognosis of singular paracondromatoid parosteal osteochondromatous proliferation.Methods 5 cases of BPOP were stained with HE and the related literatures were reviewed.Results the age of onset of 5 BPOP patients was 1748 years old. There was no difference in sex. All patients were ill with pain and swelling. The lesions were located in long limbs, short tubular bone. X ray showed a clear high density mass with wide basal margin, and originated from the intact bone cortex under periosteal.There was no connection between the site of the lesion and the medullary cavity of the attached bone, including one case with slight destruction of the bone cortex attached to the bone.Under the microscope, it was found that cartilage, bone and fibrous tissue were arranged irregularly, and mild abnormal chondrocytes could be accompanied by most calcified cartilage, that is, "blue bone" in the pleomorphic trabecular bone, and there were no abnormal osteoblasts around the bone trabeculae.There are a large number of blood vessels between trabeculae and fibrous tissue hyperplasia.Conclusion BPOP is a rare and benign osteochondromatoid lesion with high recurrence, no metastasis and rare malignant change. It is easy to be misdiagnosed with osteosarcoma and chondrosarcoma in combination with imaging and histopathologic features.Differentiation of ossifying myositis.
【作者單位】： 安徽省宿州市立醫(yī)院病理科;蚌埠醫(yī)學(xué)院病理學(xué)教研室;
【分類號】：R681
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本文編號：1754578