本文選題：右美托咪定 + 老年�。� 參考：《中南大學(xué)學(xué)報(醫(yī)學(xué)版)》2017年05期

【摘要】：目的:觀察右美托咪定對冠心病患者圍手術(shù)期心臟不良事件的影響。方法:擇期行開腹胃癌切除術(shù)的老年冠心病患者60例,采用隨機數(shù)字表法將其分為右美托咪定組(Dex組)與對照組(Control組),每組30例。兩組患者麻醉管理一致,其中Dex組誘導(dǎo)麻醉前10 min靜脈微量泵入右美托咪定0.5μg/kg,10 min后繼續(xù)泵注維持量0.5μg/(kg·h)至手術(shù)結(jié)束;Control組在同一時點采用等量的生理鹽水靜脈輸注。分別于術(shù)前、術(shù)畢、術(shù)后24 h采集靜脈血標本,測定肌鈣蛋白I(c Tn I)、N-末端腦利鈉肽原(N-terminal pro-brain natriuretic peptide,NT-pro BNP)、超敏C反應(yīng)蛋白(hypersensitive C-reactive protein,hs-CRP)的水平。記錄術(shù)中、術(shù)后3 d心臟不良事件的發(fā)生情況。結(jié)果:兩組患者術(shù)前血清c Tn I,NTpro BNP,hs-CRP水平比較,差異無統(tǒng)計學(xué)意義(P0.05);術(shù)后24 h時血清c Tn I,NT-pro BNP,hs-CRP較術(shù)前都顯著升高(P0.05),且Dex組在術(shù)后24 h時血清c Tn I,NT-pro BNP及hs-CRP水平明顯低于Control組(P0.05)。兩組患者術(shù)中均未發(fā)生心肌梗死;與Control組比較,Dex組心動過緩發(fā)生率升高,心動過速和心肌缺血發(fā)生率降低(P0.05)。Dex組術(shù)后無癥狀性心肌缺血和心律失常發(fā)生率與Control組相比明顯降低(P0.05)。結(jié)論:右美托咪定能夠降低老年冠心病患者圍手術(shù)期心臟不良事件的發(fā)生率。
[Abstract]:Objective: to observe the effect of dexmetomidine on adverse cardiac events in patients with coronary heart disease.Methods: sixty elderly patients with coronary heart disease undergoing open gastric cancer resection were randomly divided into dexmetomidine group (n = 30) and control group (n = 30).The anesthesia management of the two groups was the same. The Dex group received intravenous infusion of dexmetomidine 0.5 渭 g / kg for 10 min before induction anesthesia, and the maintenance volume was 0.5 渭 g/(kg / h after the operation. The same amount of saline was given to the Dex group at the same time point.Venous blood samples were collected before, at the end of operation and 24 hours after operation. The levels of N-terminal pro-brain natriuretic peptide N-terminal pro-brain natriuretic peptide NT-pro BNPP, hypersensitive C-reactive protein hs-CRP were measured.Adverse cardiac events were recorded 3 days after operation.Compared with the Control group, the incidence of bradycardia increased and the incidence of tachycardia and myocardial ischemia decreased in the two groups. The incidence of asymptomatic myocardial ischemia and arrhythmia in the Dex group was significantly lower than that in the Control group.Conclusion: dexmetomidine can reduce the incidence of perioperative adverse cardiac events in elderly patients with coronary heart disease.
【作者單位】： 河北醫(yī)科大學(xué)第四醫(yī)院麻醉科;即墨市人民醫(yī)院麻醉科;首都兒科研究所附屬兒童醫(yī)院麻醉科;
【分類號】：R614

【相似文獻】

相關(guān)碩士學(xué)位論文 前2條

1 馬海平;冠心病患者圍術(shù)期血栓前狀態(tài)與心臟不良事件的相關(guān)性研究[D];新疆醫(yī)科大學(xué);2012年

2 王鶴;老年非心臟手術(shù)患者術(shù)前高敏C反應(yīng)蛋白與術(shù)后心臟不良事件的相關(guān)性研究[D];昆明醫(yī)學(xué)院;2009年

，

本文編號：1739085