本文選題：膿毒癥　切入點(diǎn)：鹽酸右美托咪定　出處：《中華醫(yī)院感染學(xué)雜志》2017年03期

【摘要】：目的探討鹽酸右美托咪定對(duì)膿毒癥患者圍手術(shù)期血清白細(xì)胞介素-10(Interleukin-10,IL-10)、白細(xì)胞介素-6(Interleukin-6,IL-6)、腫瘤壞死因子-α(Tumor necrosis factor-α,TNF-α)及高遷移率族蛋白B1(High mobility group protein B1,HMGB1)的影響。方法選擇醫(yī)院2014年1月-2015年12月需手術(shù)治療的膿毒癥患者94例為研究對(duì)象,將其分為右美托咪定組和對(duì)照組,每組各47例,右美托咪定組患者麻醉過(guò)程中靜脈泵入鹽酸右美托咪定,對(duì)照組靜脈泵入等量生理鹽水,采用ELISA法測(cè)定血清IL-10、IL-6、TNF-α和HMGB1水平。結(jié)果兩組患者手術(shù)結(jié)束時(shí)和術(shù)后24h血清IL-10水平均高于麻醉誘導(dǎo)前和手術(shù)1h(P0.05);與對(duì)照組比較,右美托咪定組手術(shù)結(jié)束時(shí)和術(shù)后24h血清IL-10水平明顯高于對(duì)照組(P0.05);兩組患者手術(shù)結(jié)束時(shí)和術(shù)后24h血清IL-6、TNF-α和HMGB1水平均高于麻醉誘導(dǎo)前和手術(shù)1h(P0.05);與對(duì)照組比較,右美托咪定組手術(shù)結(jié)束時(shí)和術(shù)后24h血清IL-6、TNF-α和HMGB1水平明顯低于對(duì)照組(P0.05)。結(jié)論膿毒癥患者圍手術(shù)期血清IL-10、IL-6、TNF-α和HMGB1水平均升高,右美托咪定可以降低血清IL-6、TNF-α和HMGB1水平,升高血清IL-10。
[Abstract]:Objective to investigate dexmedetomidine hydrochloride on perioperative serum IL-2 in patients with sepsis in -10 (Interleukin-10, IL-10), interleukin -6 (Interleukin-6, IL-6), tumor necrosis factor alpha (Tumor alpha factor- alpha necrosis, TNF-) and high mobility group protein B1 (High mobility group protein B1, HMGB1). The influence of selection method of hospital in January 2014 -2015 year in December the need for surgical treatment of the patients with sepsis and 94 cases as the research object, which can be divided into dexmedetomidine group and control group, 47 cases in each group, dexmedetomidine during intravenous infusion of dexmedetomidine hydrochloride group anesthesia control group, intravenous infusion of normal saline, serum IL-10 was determined by ELISA method, IL-6, TNF- alpha and HMGB1 level. Results in the end of two groups of patients with surgery and postoperative 24h serum level of IL-10 was higher than that before induction of anesthesia and surgery 1H (P0.05); compared with the control group, dexmedetomidine group At the end of 24h and postoperative serum IL-10 levels were significantly higher than the control group (P0.05); the end of the two groups of patients with operation time and postoperative serum 24h IL-6, TNF- alpha and HMGB1 was higher than before the induction of anesthesia and surgery 1H (P0.05); compared with the control group, dexmedetomidine group at the end of surgery and 24h after surgery serum IL-6, TNF- and HMGB1 levels were significantly lower than the control group (P0.05). Serum IL-10, perioperative sepsis patients conclusion during IL-6, TNF- and HMGB1 levels were elevated, dexmedetomidine can reduce the serum levels of IL-6, TNF- and HMGB1 levels, elevated serum IL-10.

【作者單位】： 義烏市中心醫(yī)院麻醉科;
【基金】：浙江省醫(yī)藥衛(wèi)生一般研究計(jì)劃基金資助項(xiàng)目(2014KYB297)
【分類(lèi)號(hào)】：R614

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