本文選題：鹽酸戊乙奎醚　切入點(diǎn)：烏司他丁　出處：《重慶醫(yī)學(xué)》2017年12期

【摘要】：目的探討鹽酸戊乙奎醚復(fù)合烏司他丁對(duì)行開胸術(shù)患者術(shù)后認(rèn)知功能的影響。方法將120例行開胸肺癌根治術(shù)患者分為鹽酸戊乙奎醚復(fù)合烏司他丁組(HU組)、鹽酸戊乙奎醚組(H組)、烏司他丁組(U組)和對(duì)照組(C組)。采集動(dòng)脈血檢測(cè)氧合指數(shù)(OI)、腫瘤壞死因子α(TNF-α)、白細(xì)胞介素(IL)-6和IL-8,檢測(cè)血清中S-100β和神經(jīng)元特異性烯醇化酶(NSE)水平,評(píng)估簡(jiǎn)易精神狀態(tài)評(píng)價(jià)量表(MMSE)評(píng)分。結(jié)果與H組和U組相比,HU組T3~4時(shí)TNF-α均降低,T2~4時(shí)IL-6和IL-8均降低,而OI升高(P0.05);與H組和U組相比,HU組患者T5~8時(shí)血清S-100β和NSE水平均降低(P0.05);與H組和U組相比,HU組患者T6~7時(shí)MMSE評(píng)分升高(P0.05)。結(jié)論鹽酸戊乙奎醚復(fù)合烏司他丁可減輕開胸術(shù)單肺通氣時(shí)炎癥反應(yīng),改善術(shù)后認(rèn)知功能。
[Abstract]:Objective to investigate the effect of pentehyclidine hydrochloride combined with ulinastatin on cognitive function of patients undergoing thoracotomy.Methods 120 patients with open chest lung cancer were divided into three groups: penehyclidine hydrochloride combined with ulinastatin group (Hu group), penehyclidine hydrochloride group (group H), ulinastatin group (group U) and control group (group C).Arterial blood samples were collected to detect the oxygenation index (OIN), tumor necrosis factor- 偽 (TNF- 偽), interleukin-6 (IL-6) and interleukin-8 (IL-8). The levels of S-100 尾 and neuron-specific enolase (NSEs) were measured to evaluate the MMSE score.緇撴灉涓嶩緇勫拰U緇勭浉姣，

本文編號(hào)：1710635