本文選題：鹽酸戊乙奎醚　切入點：烏司他丁　出處：《重慶醫(yī)學》2017年12期

【摘要】：目的探討鹽酸戊乙奎醚復合烏司他丁對行開胸術患者術后認知功能的影響。方法將120例行開胸肺癌根治術患者分為鹽酸戊乙奎醚復合烏司他丁組(HU組)、鹽酸戊乙奎醚組(H組)、烏司他丁組(U組)和對照組(C組)。采集動脈血檢測氧合指數(shù)(OI)、腫瘤壞死因子α(TNF-α)、白細胞介素(IL)-6和IL-8,檢測血清中S-100β和神經(jīng)元特異性烯醇化酶(NSE)水平,評估簡易精神狀態(tài)評價量表(MMSE)評分。結果與H組和U組相比,HU組T3~4時TNF-α均降低,T2~4時IL-6和IL-8均降低,而OI升高(P0.05);與H組和U組相比,HU組患者T5~8時血清S-100β和NSE水平均降低(P0.05);與H組和U組相比,HU組患者T6~7時MMSE評分升高(P0.05)。結論鹽酸戊乙奎醚復合烏司他丁可減輕開胸術單肺通氣時炎癥反應,改善術后認知功能。
[Abstract]:Objective to investigate the effect of pentehyclidine hydrochloride combined with ulinastatin on cognitive function of patients undergoing thoracotomy.Methods 120 patients with open chest lung cancer were divided into three groups: penehyclidine hydrochloride combined with ulinastatin group (Hu group), penehyclidine hydrochloride group (group H), ulinastatin group (group U) and control group (group C).Arterial blood samples were collected to detect the oxygenation index (OIN), tumor necrosis factor- 偽 (TNF- 偽), interleukin-6 (IL-6) and interleukin-8 (IL-8). The levels of S-100 尾 and neuron-specific enolase (NSEs) were measured to evaluate the MMSE score.緇撴灉涓嶩緇勫拰U緇勭浉姣，

本文編號：1710635