本文選題：骨折愈合　切入點(diǎn)：肌肉　出處：《中國(guó)骨質(zhì)疏松雜志》2017年10期

【摘要】：骨修復(fù)是一個(gè)復(fù)雜的過(guò)程,包括組織、細(xì)胞和分子水平上的生物事件。骨折愈合主要分為炎癥、修復(fù)和重塑三個(gè)生理過(guò)程。在修復(fù)過(guò)程進(jìn)展中最主要的事件是骨骼干細(xì)胞的募集、增殖、擴(kuò)張和積聚。骨骼干細(xì)胞主要源于骨膜等局部骨組織,但是在骨膜損傷較嚴(yán)重的情況下骨修復(fù)仍然可以進(jìn)行。研究發(fā)現(xiàn),機(jī)體還存在其他潛在的干細(xì)胞來(lái)源,從而對(duì)缺失和損傷的骨骼干細(xì)胞進(jìn)行補(bǔ)償。鑒于肌肉與骨骼相鄰,且與骨骼的生長(zhǎng)發(fā)育密切相關(guān),近來(lái)肌肉組織又被研究認(rèn)為是分泌器官。因此,肌肉組織是骨修復(fù)細(xì)胞和生長(zhǎng)因子的重要來(lái)源。本文通過(guò)論述肌肉組織作為骨骼干細(xì)胞的來(lái)源,其分泌的肌肉因子以及自身作為重要元件對(duì)骨修復(fù)的作用,以期望為骨科治療提供新的見(jiàn)解。
[Abstract]:Bone repair is a complex process, including tissue, cellular and molecular level of biological events including inflammation. The healing of fracture, repair and remodeling of three physiological processes. In the repair process in the main event is bone marrow stem cell recruitment, proliferation, expansion and accumulation of bone marrow stem cells mainly derived from. The periosteum of local bone tissue, but in the case of serious injury of periosteal bone repair can still be carried out. The study found that the body there are other potential sources of stem cells, which lack of compensation and injury of skeletal stem cells. In view of the adjacent muscle and bone, and bone growth and development is closely related to muscle tissue and the research was considered secretory organs recently. Therefore, muscle tissue is an important source of bone repair cells and growth factors. This paper discusses the skeletal muscle tissue as a source of stem cells, the secretion of muscle Factors and their role as important components in bone repair are expected to provide new insights for the treatment of Department of orthopedics.

【作者單位】： 華東師范大學(xué)青少年健康評(píng)價(jià)與運(yùn)動(dòng)干預(yù)教育部重點(diǎn)實(shí)驗(yàn)室;華東師范大學(xué)體育與健康學(xué)院;
【基金】：《青少年健康評(píng)價(jià)與運(yùn)動(dòng)干預(yù)》教育部重點(diǎn)實(shí)驗(yàn)室項(xiàng)目(40500-541235-14203/004)
【分類號(hào)】：R68
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本文編號(hào)：1694684