本文選題：急性高容量血液稀釋　切入點(diǎn)：術(shù)后早期認(rèn)知功能　出處：《實(shí)用醫(yī)學(xué)雜志》2017年21期

【摘要】：目的探討輕度急性高容量血液稀釋對(duì)脊柱手術(shù)老年患者術(shù)后早期認(rèn)知功能障礙的影響。方法選擇擬全身麻醉下行擇期骨科脊柱手術(shù)患者60例,年齡65~80歲,體質(zhì)指數(shù)18.5~30.0 kg/m~2,ASAⅠ~Ⅱ。根據(jù)隨機(jī)數(shù)字表法分為兩組:AHH組和對(duì)照組。麻醉誘導(dǎo)后AHH組20 mL/min速度輸注6%羥乙基淀(130/0.4)行急性高容量血液稀釋。對(duì)照組常規(guī)輸入復(fù)方乳酸鈉15 mL/kg補(bǔ)充禁食禁飲、生理需要量。分別于入室即刻(T_0)、AHH后[對(duì)照組為手術(shù)開始時(shí)(T_1)]、術(shù)畢時(shí)(T_2)、術(shù)畢后6 h(T_3)、術(shù)畢后24 h(T_4)測(cè)定S-100β的變化;采用簡(jiǎn)易智力狀態(tài)檢查法計(jì)算術(shù)后1、3、7 d的術(shù)后認(rèn)知功能障礙發(fā)生率。結(jié)果兩組患者一般情況的比較差異無(wú)統(tǒng)計(jì)學(xué)意義;T_2、T_3與T_4時(shí)間點(diǎn)兩組的S-100β濃度高于T_0時(shí),T_3與T_4時(shí)間點(diǎn)對(duì)照組的S-100β濃度高于AHH組(P0.05)。兩組患者術(shù)后認(rèn)知功能障礙的發(fā)生率差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論輕度高容量血液稀釋用于老年患者脊柱手術(shù),降低S-100β的水平,不增加術(shù)后認(rèn)知功能障礙的風(fēng)險(xiǎn)。
[Abstract]:Objective to investigate the effect of mild acute hypervolemic hemodilution on early cognitive impairment after spinal surgery in elderly patients.Methods A total of 60 patients, aged 6580 years, undergoing elective orthopedic spine surgery under general anesthesia, with a body mass index (BMI) of 30.0 kg / m ~ (2) and ASA 鈪，

本文編號(hào)：1689451