本文選題：磁共振成像　切入點(diǎn)：相位對(duì)比　出處：《寧夏醫(yī)科大學(xué)》2015年碩士論文

【摘要】：目的:應(yīng)用磁共振相位對(duì)比電影成像(Phase-contrast cine Magnetic Resonance Imaging,PC cine MRI)分析正常志愿者、交通性腦積水、不同部位梗阻性腦積水腦導(dǎo)水管平面CSF流動(dòng)曲線、流量、流速、絕對(duì)搏出量(Absolute Stroke Volume,ASV)及中腦導(dǎo)水管中段(壺腹部)面積,研究不同組別之間流動(dòng)特性的差異,并探討應(yīng)用PC cine MRI在腦積水的診療評(píng)估的臨床價(jià)值。方法:設(shè)立正常志愿者組5例;腦積水組:交通性腦積水腦積水組8例,梗阻性腦積水7例(中腦導(dǎo)水管狹窄4例、三室占位2例、四室占位1例)。應(yīng)用philips I n t e r a Achieva 1.5T超導(dǎo)磁共振掃描儀,采用外周門控,MRI分別采集顱腦常規(guī)圖像及CSF流量(或流速)分析圖像。掃描數(shù)據(jù)輸入后傳到MR Extended Workspace R2.6.31工作站,用CSF-QF-Clear軟件對(duì)導(dǎo)水管內(nèi)CSF流動(dòng)進(jìn)行定性與定量分析。對(duì)比分析不同組別CSF流動(dòng)曲線、流量、流速、絕對(duì)搏出量、中腦導(dǎo)水管中段(壺腹部)面積。結(jié)果:5例正常志愿者CSF流動(dòng)曲線呈正弦波形;8例交通性腦積水組呈欠規(guī)則正弦波形;中腦導(dǎo)水管狹窄性與三室占位、四室占位性梗阻性腦積水曲線圖分別呈4例欠規(guī)則鋸齒狀及3例欠規(guī)則正弦波形。正常志愿者與三室占位腦積水流量(或流速)無(wú)統(tǒng)計(jì)學(xué)意義(P0.05);余各組間比較均具有統(tǒng)計(jì)學(xué)義(P0.05)。正常志愿者中腦導(dǎo)水管面積與交通性腦積水、中腦導(dǎo)水管狹窄性梗阻性腦積水組間有統(tǒng)計(jì)學(xué)意義(P0.05)。交通性腦積水ASV分別于正常志愿者、中腦導(dǎo)水管狹窄性、三室占位性及四室占位性梗阻性腦積水組之間有統(tǒng)計(jì)學(xué)差異(P0.05)。結(jié)論:(1)正常志愿者CSF流動(dòng)曲線呈正弦波形,交通性腦積水呈欠規(guī)則正弦波形,梗阻性腦積水呈欠規(guī)則鋸齒狀或欠規(guī)則正弦波形。(2)交通性腦積水通過(guò)ROI面積的流量(流速)最高,四腦室占位性梗阻性腦積水具第二,正常志愿者與三室占位性梗阻性腦積水居第三,中腦導(dǎo)水管狹窄性梗阻性腦積水最低。(3)交通性腦積水的ROI面積最大,中腦導(dǎo)水管狹窄性梗阻性腦積水ROI面積最小。(4)交通性通性腦積水ASV最大,腦室順應(yīng)性最差。
[Abstract]:Objective: to analyze the CSF flow curve, flow rate, flow rate and velocity of cerebral aqueduct in normal volunteers, traffic hydrocephalus and obstructive hydrocephalus by using phase contrast imaging of magnetic resonance phase contrast cine cine Magnetic Resonance imaging PC cine MRI. Absolute Stroke volume (ASV) and midbrain aqueduct (ampulla) were used to study the difference of flow characteristics among different groups, and to evaluate the clinical value of PC cine MRI in the diagnosis and treatment of hydrocephalus. In the hydrocephalus group, there were 8 cases of communicating hydrocephalus, 7 cases of obstructive hydrocephalus (4 cases of mesencephalic aqueduct stenosis, 2 cases of three-compartment space occupation and 1 case of four-ventricular occupying position). The superconducting magnetic resonance scanner (philips I n t e r a Achieva 1.5T) was used. Peripheral gated MRI was used to collect conventional brain images and CSF flow (or velocity) analysis images. The scanning data were inputted to Mr Extended Workspace R2.6.31 workstation. The qualitative and quantitative analysis of CSF flow in aqueduct was carried out by CSF-QF-Clear software. The flow curve, flow rate, flow velocity, absolute stroke volume of CSF in different groups were compared and analyzed. Results the CSF flow curve of 5 normal volunteers was sinusoidal and 8 cases of communicating hydrocephalus showed irregular sinusoidal shape, the mesencephalic aqueduct stenosis and three-ventricular space occupied, the area of midbrain aqueduct in middle segment (ampulla) of 5 normal volunteers was sinusoidal. The curve of four-compartment obstructive hydrocephalus was irregular serrated in 4 cases and irregular sine wave in 3 cases. There was no significant difference in flow (or velocity) between normal volunteers and three-compartment occupying hydrocephalus (P 0.05). The area of cerebral aqueduct and communicating hydrocephalus in normal volunteers. There was statistically significant difference between patients with obstructive hydrocephalus with stenosis of aqueduct in midbrain (P 0.05). ASV of communicating hydrocephalus was significantly higher than that of normal volunteers and stenosis of aqueduct of midbrain. There was significant difference between the three compartment occupying and four compartment obstructive hydrocephalus groups (P 0.05). Conclusion the CSF flow curve of normal volunteers is sinusoidal, and the traffic hydrocephalus is irregular sine wave. Obstructive hydrocephalus presented irregular zigzag or irregular sinusoidal shape. 2) the flow rate (velocity) of communicating hydrocephalus through ROI area was the highest, and the fourth ventricle occupied obstructive hydrocephalus was the second. The ROI area of communicating hydrocephalus was the largest in normal volunteers and three-ventricle occupied obstructive hydrocephalus, and the lowest in mesencephalic aqueduct stenosis obstructive hydrocephalus, and the lowest in mesencephalic aqueduct stenosis obstructive hydrocephalus. The area of ROI in obstructive hydrocephalus with aqueduct stenosis was the smallest. 4) the ASV of communicating hydrocephalus was the largest and the compliance of ventricle was the worst.
【學(xué)位授予單位】：寧夏醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：R651.1

【二級(jí)參考文獻(xiàn)】

相關(guān)期刊論文 前1條

1 徐yN;余新光;杜長(zhǎng)生;;正常及異常腦脊液流動(dòng)的磁共振研究[J];山東醫(yī)藥;2008年09期

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本文編號(hào)：1680678