本文選題：乳腺癌　切入點(diǎn)：內(nèi)乳淋巴結(jié)　出處：《蘇州大學(xué)》2015年碩士論文　論文類型：學(xué)位論文

【摘要】：研究目的探討乳腺癌內(nèi)乳淋巴結(jié)轉(zhuǎn)移相關(guān)危險(xiǎn)因素,強(qiáng)調(diào)內(nèi)乳淋巴結(jié)在乳腺癌分期及預(yù)后有著非常重要的臨床意義,根據(jù)內(nèi)乳淋巴結(jié)轉(zhuǎn)移的風(fēng)險(xiǎn)因素,為今后研究?jī)?nèi)乳淋巴結(jié)活檢的臨床意義。方法我們從上海瑞金醫(yī)院乳腺腫瘤中心,回顧性分析142例乳腺癌擴(kuò)大根治術(shù)臨床資料,選取病人年齡、腫瘤T分期、最終腫瘤大小、腫瘤位置、腫瘤病理分類、激素受體、淋巴管浸潤(rùn)及腋窩淋巴結(jié)轉(zhuǎn)移狀況共8個(gè)與乳腺癌內(nèi)乳淋巴結(jié)轉(zhuǎn)移可能相關(guān)的因素,采用統(tǒng)計(jì)方法Χ2檢驗(yàn)和秩和檢驗(yàn)(P=0.05)。結(jié)果選取的22例乳腺癌內(nèi)乳淋巴結(jié)轉(zhuǎn)移的患者中,內(nèi)乳淋巴結(jié)轉(zhuǎn)移相關(guān)的8個(gè)危險(xiǎn)因素中,腫瘤的T分期(P0.1)、腫瘤的位置(P=0.25,P0.1)、腫瘤病理(0.1)、及激素受體(ER P=0.9,PR P=0.6)不是影響內(nèi)乳淋巴結(jié)轉(zhuǎn)移的獨(dú)立因素(P0.05)。而與患者的年齡(P0.001)、淋巴管浸潤(rùn)(P=0.01)、最終腫瘤大小(P=0.025)和腋窩淋巴結(jié)陽性(P0.005)相關(guān)(P0.05),并且腋窩淋巴結(jié)陽性個(gè)數(shù)≥4的患者較4個(gè)患者發(fā)生內(nèi)乳淋巴結(jié)轉(zhuǎn)移有著明顯差異(P0.005)。結(jié)論142例患者中,內(nèi)乳淋巴結(jié)陽性22例(15.5%),具有淋巴管浸潤(rùn)、最終腫瘤越小、腋窩淋巴結(jié)陽性且陽性個(gè)數(shù)≥4的年輕病人是內(nèi)乳淋巴結(jié)轉(zhuǎn)移的高�；颊�。
[Abstract]:Objective to investigate the risk factors associated with intramammary lymph node metastasis in breast cancer, and to emphasize that internal mammary lymph node plays an important role in the staging and prognosis of breast cancer. Methods the clinical data of 142 patients with breast cancer undergoing extended radical mastectomy were retrospectively analyzed from the breast tumor center of Ruijin Hospital in Shanghai. The patients' age, T stage and final tumor size were selected. Tumor location, pathological classification, hormone receptor, lymphatic invasion and axillary lymph node metastasis were 8 possible factors associated with breast cancer intramammary lymph node metastasis. Results among 22 breast cancer patients with intramammary lymph node metastasis, 8 risk factors were associated with internal mammary lymph node metastasis. The T staging of the tumor, the location of the tumor, the location of the tumor, the pathology of the tumor, and the hormone receptor ER P0. 9 / PR P0. 6) are not independent factors affecting the metastasis of the medial mammary lymph node, but not the age of the patient (P 0. 001, lymphatic vessel infiltrating P 0. 01, and ultimately the size of the tumor P0. 025) and axillary lymph node. There were significant differences in the incidence of intramammary lymph node metastasis in patients with positive number of axillary lymph nodes (鈮，

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