本文選題：丙泊酚注射液　切入點(diǎn)：瑞芬太尼注射液　出處：《中國臨床藥理學(xué)雜志》2017年11期 　論文類型：期刊論文

【摘要】：目的觀察丙泊酚聯(lián)合不同劑量瑞芬太尼對患者疼痛敏感度的影響。方法 76例全身麻醉手術(shù)治療的患者隨機(jī)分為試驗(yàn)組和對照組,每組38例。試驗(yàn)組瑞芬太尼用量為4 ng·mL~(-1),對照組瑞芬太尼用量為2 ng·mL~(-1)。對患者用藥前、插管前、插管后2,4,6 min的平均動脈壓、舒張壓、收縮壓及心率進(jìn)行記錄,比較2組患者的疼痛分級與藥物不良反應(yīng)的發(fā)生情況。結(jié)果試驗(yàn)組的無痛發(fā)生率為76.32%(29/38例),對照組為26.31%(10/38例,P0.05)。插管前、插管后2,4,6 min,2組患者的平均動脈壓、舒張壓、收縮壓、心率均呈不同程度的降低趨勢。插管后6 min,試驗(yàn)組的平均動脈壓為(74.32±6.66)mmHg,舒張壓為(68.56±6.11)mmHg,收縮壓為(96.86±14.65)mmHg,心率為(61.11±6.42)times·min~(-1);對照組分別為(75.53±7.11),(65.35±5.53),(95.32±13.53)mmHg和(62.42±5.21)times·min~(-1),差異均無統(tǒng)計(jì)學(xué)意義(均P0.05);2組與治療前相比,差異均有統(tǒng)計(jì)學(xué)意義(均P0.05)。試驗(yàn)組出現(xiàn)發(fā)熱1例、呼吸抑制1例、惡心2例、嘔吐2例,藥物不良反應(yīng)發(fā)生率為15.79%(6/38例);對照組出現(xiàn)嘔吐1例、眩暈1例、惡心2例、呼吸抑制3例,藥物不良反應(yīng)發(fā)生率為18.42%(7/38例),差異無統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論 2,4 ng·mL~(-1)的瑞芬太尼均能減慢患者的心率,降低血壓水平,但瑞芬太尼的藥物用量為4 ng·mL~(-1)時(shí),更能有效緩解患者注射丙泊酚的疼痛敏感度。
[Abstract]:Objective to observe the effect of propofol combined with remifentanil on pain sensitivity. Methods 76 patients undergoing general anesthesia were randomly divided into trial group and control group. There were 38 patients in each group. The dosage of remifentanil was 4 ng 路mL ~ (-1) in the trial group and 2 ng 路mL ~ (-1) in the control group. The mean arterial pressure, diastolic pressure, systolic pressure and heart rate were recorded before, before and after the intubation. Results the incidence of painless pain was 76.32 / 29 / 28 in the trial group and 26.31 / 10 / 10 / 10 / 38 in the control group (P < 0.05). The mean arterial pressure, diastolic pressure, systolic blood pressure were measured before intubation and 2 minutes after intubation. At 6 min after intubation, the mean arterial pressure, diastolic pressure, systolic pressure and heart rate were 74.32 鹵6.66nhg, 68.56 鹵6.11hg, 96.86 鹵14.65mHg, 61.11 鹵6.42times 路min-1, respectively, in the control group (75.53 鹵7.11hg, 95.32 鹵13.53mmHg and 62.42 鹵5.21times 路min-1), respectively. There was no significant difference between the two groups. The difference was statistically significant (P 0.05). There were 1 case of fever, 1 case of respiratory depression, 2 cases of nausea and 2 cases of vomiting in the experimental group, and the incidence of adverse drug reaction was 15.79% in 6 / 38 cases, while in the control group, vomiting occurred in 1 case, vertigo in 1 case, nausea in 2 cases. There were 3 cases of respiratory depression, and the incidence of adverse drug reactions was 18.42 / 7 / 38. There was no significant difference (P 0.05). Conclusion remifentanil (2ng 路mL ~ (-1)) can decrease heart rate and blood pressure level, but when remifentanil dosage is 4 ng 路mL ~ (-1), remifentanil can decrease the heart rate and blood pressure level of the patients, but the dosage of remifentanil is 4 ng 路mL ~ (-1). More effective in reducing the pain sensitivity of patients injected with propofol.
【作者單位】： 杭州師范大學(xué)附屬醫(yī)院麻醉科;浙江省立同德醫(yī)院麻醉科;
【基金】：浙江省醫(yī)藥衛(wèi)生科技基金資助項(xiàng)目(2012KYB046)
【分類號】：R614
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本文編號：1587422