本文選題：組織工程化軟骨　切入點：富血小板血漿　出處：《基因組學(xué)與應(yīng)用生物學(xué)》2017年09期 　論文類型：期刊論文

【摘要】：為探討組織工程化軟骨與富血小板血漿復(fù)合修復(fù)軟骨缺損的效果,本研究選取了8周齡健康新西蘭兔24只,依據(jù)隨機數(shù)表法分為觀察組(組織工程化軟骨與富血小板血漿復(fù)合)和對照組(單純軟骨缺損模型),發(fā)現(xiàn)術(shù)后4周、8周、12周,觀察組實驗動物的大體評分均明顯高于對照組(p0.05)。觀察組實驗動物的Collagen TypeⅠ、Collagen TypeⅡ相對表達水平明顯高于對照組(p0.05)。兩組實驗動物的Collagen TypeⅩ相對表達水平無顯著差異(p0.05)。觀察組實驗動物的軟骨缺損直徑和缺損深度分別為(1.02±0.35)mm、(0.96±0.27)mm,對照組實驗動物的軟骨缺損直徑和缺損深度分別為(4.27±1.09)mm、(5.43±1.85)mm(p0.05),表明組織工程化軟骨與富血小板血漿復(fù)合修復(fù)軟骨缺損效果明顯,能夠刺激軟骨相關(guān)基因表達,縮小軟骨缺損范圍,促進缺損軟骨愈合。
[Abstract]:In order to investigate the effect of tissue engineered cartilage and platelet-rich plasma on repairing cartilage defects, 24 8-week-old healthy New Zealand rabbits were selected in this study. According to the random number table method, the patients were divided into observation group (tissue engineered cartilage combined with platelet-rich plasma) and control group (simple cartilage defect model). The gross scores of experimental animals in the observation group were significantly higher than those in the control group, and the relative expression level of Collagen Type 鈪，

本文編號：1585325