本文選題：可降解支架　切入點(diǎn)：鎂合金　出處：《介入放射學(xué)雜志》2017年09期 　論文類型：期刊論文

【摘要】：目的體外研究硅膜-鎂合金可降解支架的機(jī)械特性和降解行為,體內(nèi)研究其置入兔食管的可行性及組織反應(yīng)。方法體外測試硅膜-鎂合金可降解支架的機(jī)械壓縮恢復(fù)性能和降解行為。30只健康荷蘭兔隨機(jī)分為硅膜-鎂合金支架組(n=15,透視導(dǎo)引下將支架置入兔食管下1/3段)和對照組(n=15,未作任何干預(yù)),支架置入后1、2、4周兩組兔分別接受食管造影,同時于各時間點(diǎn)分別處死5只兔,取材作組織學(xué)檢查。結(jié)果體外測試顯示硅膜-鎂合金可降解支架表現(xiàn)出良好的柔韌性和彈性,在p H4.0、p H7.4磷酸緩沖液中降解均慢于鎂合金裸支架;體內(nèi)測試顯示支架置入后所有實(shí)驗兔耐受性良好,食管直徑在置入前為(9.2±0.8)mm,置入后1、2、4周分別為(9.7±0.7)mm、(9.6±0.8)mm、(9.6±0.5)mm(P0.05)。支架組6只兔發(fā)生支架移位(1周時1只,2周時1只,4周時4只)。支架組食管上皮、平滑肌層變薄等食管壁重建與對照組比較,差異有統(tǒng)計學(xué)意義(P0.05);支架置入后食管壁損傷及膠原沉積等組織反應(yīng)與對照組比較,差異無統(tǒng)計學(xué)意義(P0.05)。結(jié)論硅膜-鎂合金可降解支架置入兔食管技術(shù)上可行,可提供至少2周支撐力,支架移位率可接受,未發(fā)生嚴(yán)重食管壁損傷及膠原沉積。
[Abstract]:Objective to study the mechanical properties and degradation behavior of silicon film magnesium alloy degradable scaffolds in vitro. Methods the mechanical compression recovery and degradation behavior of silicon film magnesium alloy degradable scaffolds were measured in vitro. 30 healthy Dutch rabbits were randomly divided into silicon film magnesium alloy scaffolds. The two groups received esophagography 1 ~ 2 and 4 weeks after implantation of stents under fluoroscopic guidance) and control group (n = 15) without any intervention. At the same time, 5 rabbits were killed at each time point, and the materials were taken for histological examination. Results in vitro tests showed that silicon film and magnesium alloy degradable scaffolds showed good flexibility and elasticity. The degradation rate in pH 4.0 and pH 7.4 phosphate buffer solution was slower than that in bare magnesium alloy scaffolds, and in vivo tests showed that all experimental rabbits had good tolerance after implantation of the scaffolds. The esophageal diameter was 9.2 鹵0.8mm before implantation and 9.7 鹵0.7mm / 4 weeks after implantation, respectively. The mean diameter of esophagus in the stent group was 9.6 鹵0.5mm / mm, 9.6 鹵0.5mm / mm respectively. In the stent group, 6 rabbits underwent stenting for 1 week, 1 rabbit in the second week and 4 in the 4th week. The esophageal epithelium and smooth muscle layer thinned in the stent group were compared with those in the control group, and the esophageal epithelium and smooth muscle layer of the stent group were thinner than that of the control group, and the esophageal epithelium and smooth muscle layer of the stent group were thinner than those of the control group. Compared with the control group, there was no significant difference between the two groups. Conclusion it is feasible to put silicon film and magnesium alloy degradable scaffold into rabbit esophagus. Can provide at least 2 weeks of support, support rate is acceptable, there is no serious injury to the wall of the esophagus and collagen deposition.
【作者單位】： 上海交通大學(xué)附屬第六人民醫(yī)院影像科;蘇州大學(xué)骨科研究所;
【基金】：國家自然科學(xué)基金(81370041、81371659、81571773)
【分類號】：R318.08;R655.4

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