本文關(guān)鍵詞： 骨關(guān)節(jié)炎 抵抗素 滑液 生物學(xué)標(biāo)記 組織工程 組織構(gòu)建 骨組織工程 關(guān)節(jié)滑液 生物標(biāo)記物　出處：《中國(guó)組織工程研究》2017年16期 　論文類(lèi)型：期刊論文

【摘要】：背景:研究顯示抵抗素表達(dá)水平與骨關(guān)節(jié)炎的發(fā)病機(jī)制密切相關(guān)。目的:旨在探討膝骨關(guān)節(jié)炎患者的血清和關(guān)節(jié)液中抵抗素水平與膝關(guān)節(jié)病變程度的相關(guān)性。方法:選取74例膝骨關(guān)節(jié)炎患者和79例健康對(duì)照者,通過(guò)關(guān)節(jié)鏡進(jìn)行軟骨損傷程度評(píng)分;WOMAC評(píng)分來(lái)評(píng)估患者的癥狀嚴(yán)重程度;X射線K-L分級(jí)系統(tǒng)評(píng)估膝關(guān)節(jié)影像學(xué)分級(jí);ELISA檢測(cè)血清和關(guān)節(jié)液中抵抗素及Ⅱ型膠原基端端肽水平。結(jié)果與結(jié)論:(1)關(guān)節(jié)液中抵抗素水平與膝放射學(xué)病變程度X射線K-L分級(jí)呈正相關(guān),與WOMAC評(píng)分中疼痛、肢體功能及總評(píng)分成正相關(guān),與WOMAC僵硬評(píng)分無(wú)顯著的相關(guān)性;(2)骨關(guān)節(jié)炎組血清抵抗素水平與WOMAC總分、各分項(xiàng)評(píng)分及X射線K-L分級(jí)評(píng)分差異均無(wú)顯著的相關(guān)性;(3)多元回歸分析在去除混合因素后,顯示關(guān)節(jié)液中抵抗素水平與WOMAC評(píng)分差異有顯著性意義,關(guān)節(jié)液中抵抗素水平與Noyes評(píng)分及CTX-II水平成正相關(guān);(4)結(jié)果說(shuō)明,關(guān)節(jié)液中抵抗素水平在反映膝骨關(guān)節(jié)炎患者的病變嚴(yán)重程度及關(guān)節(jié)軟骨退變程度上可能作為一個(gè)潛在的生物標(biāo)志物。
[Abstract]:Background: studies have shown that the expression of resistin is closely related to the pathogenesis of osteoarthritis. Objective: to investigate the correlation between serum and fluid resistin levels and the degree of knee joint disease in patients with knee osteoarthritis. Methods: 74 patients with knee osteoarthritis and 79 healthy controls were selected. The degree of cartilage injury was evaluated by arthroscopy. WOMAC score was used to evaluate the severity of symptoms. X-ray K-L grading system was used to evaluate the imaging grade of knee joint. The levels of resistin and type 鈪，

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