本文關(guān)鍵詞： 右美托咪定 超氧化物歧化酶 丙二醛 白細(xì)胞介素- 腎上腺腫瘤　出處：《中國臨床藥理學(xué)雜志》2017年18期 　論文類型：期刊論文

【摘要】：目的觀察右美托咪定對腹腔鏡下腎上腺腫瘤切除術(shù)老年患者血清超氧化物歧化酶(SOD)、丙二醛(MDA)以及白細(xì)胞介素-6(IL-6)水平的影響。方法將56例進(jìn)行腹腔鏡下腎上腺腫瘤切除術(shù)的老年患者隨機(jī)分為對照組28例和試驗組28例。對照組予以臨床常規(guī)療法,試驗組在與對照組的基礎(chǔ)上,在麻醉誘導(dǎo)插管前10 min內(nèi),予以右美托咪定注射液0.5μg·kg~(-1),qd,靜脈泵注,共7 d。比較2組患者的血清MDA、SOD和IL-6水平,以及比較麻醉前(T1)、氣腹后5 min(T_2)、氣腹后15 min(T_3)、氣腹后30 min(T_4)、氣腹結(jié)束后5min(T_5)各時點患者心率(HR)、平均動脈壓(MAP)變化以及藥物不良反應(yīng)發(fā)生率。結(jié)果治療后,試驗組和對照組血清中SOD水平分別為(87.64±11.75),(66.70±9.91)U·m L~(-1),MDA水平分別為(6.31±1.52),(8.12±1.61)nmol·m L~(-1),IL-6水平分別為(1.88±0.25),(2.19±0.31)pg·m L~(-1),差異均有統(tǒng)計學(xué)意義(P0.05)。在T2、T3時間點,對照組的HR分別為(85.54±12.17),(88.33±12.48)次/分,試驗組的HR分別為(79.24±13.47),(80.53±11.38)次/分;對照組的MAP分別為(83.57±11.14),(86.38±11.43)mm Hg,試驗組的MAP分別為(79.57±12.44),(80.18±8.33)mm Hg,2組比較差異均有統(tǒng)計學(xué)意義(P0.05)。試驗組和對照組的藥物不良反應(yīng)均為蘇醒期躁動,2組的藥物不良反應(yīng)發(fā)生率分別為7.14%(2/28例)和10.71%(3/28例),差異有統(tǒng)計學(xué)意義(P0.05)。結(jié)論右美托咪定能顯著增加血清中SOD水平,降低MDA和IL-6水平,減輕腹腔鏡下腎上腺腫瘤切除術(shù)患者的應(yīng)激反應(yīng),圍術(shù)期血流動力學(xué)平穩(wěn),藥物不良反應(yīng)發(fā)生率低。
[Abstract]:Objective to observe the effect of dexmetomidine on serum superoxide dismutase (SOD) in elderly patients undergoing laparoscopic adrenalectomy. Malondialdehyde (MDAA) and interleukin-6 (IL-6). Methods 56 elderly patients undergoing laparoscopic adrenalectomy were randomly divided into control group (n = 28) and experimental group (n = 28). The experimental group was treated with dexmetomidine injection (0.5 渭 g 路kg ~ (-1)) by intravenous infusion 10 min before anesthesia induction and intubation on the basis of the control group. The serum levels of MDA-SOD and IL-6 in the two groups were compared for 7 days, and the levels of MDA-SOD and IL-6 were compared before anesthesia, 5 min after pneumoperitoneum, 5 min after pneumoperitoneum, 15 min after pneumoperitoneum, and 15 min after pneumoperitoneum. 30 min after pneumoperitoneum, 5 min after pneumoperitoneum and 5 min after pneumoperitoneum. Results after treatment, the serum SOD levels in the trial group and the control group were 87.64 鹵11.75 respectively. The MDA levels of 66.70 鹵9.91 U 路mL ~ (-1) ~ (-1) were 6.31 鹵1.52nmol 路mL ~ (-1), respectively (8.12 鹵1.61nmol 路m ~ (-1)). The levels of IL-6 were 1.88 鹵0.25 and 2.19 鹵0.31 PG 路mL ~ (-1), respectively, and the difference was statistically significant (P < 0.05) in T2. At T3 time point, the HR of the control group was 85.54 鹵12.17, respectively, 88.33 鹵12.48 times per minute, and that of the experimental group was 79.24 鹵13.47). 80.53 鹵11.38 times / min; The MAP of the control group was 83.57 鹵11.14mm Hg, and the MAP of the test group was 79.57 鹵12.44). The difference between the two groups was statistically significant (P 0.05). The adverse drug reactions in the test group and the control group were restless during the recovery period. The incidence of adverse drug reactions in the two groups was 7.14 / 28 and 10.71 / 28 respectively). Conclusion dexmetomidine can significantly increase the level of SOD and decrease the levels of MDA and IL-6 in serum. The stress response of patients undergoing laparoscopic adrenalectomy was alleviated, hemodynamics was stable and the incidence of adverse drug reactions was low.
【作者單位】： 浙江省臺州醫(yī)院麻醉科;
【基金】：國家醫(yī)學(xué)教育發(fā)展中心醫(yī)學(xué)研究基金資助項目(2011-35-02-035)
【分類號】：R614;R736.6
【正文快照】： (浙江省臺州醫(yī)院麻醉科,浙江臺州317000)WANG Hui-jun,ZHU Li-jun,HU Guo-qiang(Department of Anesthesia,ZhejiangTaizhou Hospital,Taizhou 317000,Zhejiang Province,China)腎上腺腫瘤是發(fā)生在腎上腺皮質(zhì)、髓質(zhì)及間質(zhì)的良、惡性腫瘤以及轉(zhuǎn)移瘤和淋巴瘤,腹腔鏡腎上腺腫瘤切

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