本文關(guān)鍵詞： 溫陽除痹湯 鹽酸氨基葡萄糖片 膝關(guān)節(jié)骨性關(guān)節(jié)炎 Lysholm評分 炎癥因子　出處：《重慶醫(yī)學(xué)》2017年18期 　論文類型：期刊論文

【摘要】：目的探討中藥自擬溫陽除痹湯聯(lián)合鹽酸氨基葡萄糖治療陽虛寒凝型膝關(guān)節(jié)骨性關(guān)節(jié)炎(KOA)的臨床療效。方法篩選112例鄭州大學(xué)附屬南陽市中心醫(yī)院收治的KOA且中醫(yī)證型屬于陽虛寒凝型的患者,將其分為觀察組(n=57)和對照組(n=55),對照組給予鹽酸氨基葡萄糖治療;觀察組在對照組基礎(chǔ)上給予自擬溫陽除痹湯口服治療,兩組患者連續(xù)治療6周,比較兩組臨床療效及藥物不良反應(yīng)情況。結(jié)果觀察組關(guān)節(jié)疼痛、晨僵及畏寒肢冷等癥狀積分及Lysholm評分均低于對照組(P0.05);觀察組血清腫瘤壞死因子-α(TNF-α)、白細(xì)胞介素-6(IL-6)等炎癥指標(biāo)水平均低于對照組(P0.05);觀察組患者的總有效率為96.50%%,明顯高于對照組的78.18%(P0.05);兩組不良反應(yīng)以胃腸道表現(xiàn)為主,對照組不良反應(yīng)總發(fā)生率為10.91%,觀察組為17.54%,兩組比較差異無統(tǒng)計學(xué)意義(P0.05)。結(jié)論中藥自擬溫陽除痹湯聯(lián)合鹽酸氨基葡萄糖治療陽虛寒凝型KOA療效明顯,可更好地改善膝關(guān)節(jié)功能及炎性反應(yīng),安全可靠,值得推廣。
[Abstract]:Objective to probe into the treatment of knee osteoarthritis caused by yang deficiency and cold coagulation by Chinese herbal medicine Wenyang Debi decoction combined with glucosamine Hydrochloride (Glucosamine Hydrochloride). Methods one hundred and twelve patients with KOA treated in Nanyang Central Hospital affiliated to Zhengzhou University were selected and their TCM syndromes belonged to the type of Yang deficiency and cold coagulation. They were divided into two groups: the observation group (n = 57) and the control group (n = 55). The control group was treated with glucosamine hydrochloride. Observation group on the basis of the control group on the basis of self-prepared Wenyang Zaibi decoction oral treatment, the two groups of consecutive treatment for 6 weeks, compared the two groups of clinical efficacy and adverse drug reactions. Results the observation group joint pain. The scores of morning stiffness and cold limbs and Lysholm scores were lower than those of the control group (P 0.05). The serum levels of TNF- 偽 TNF- 偽 and IL-6 in the observation group were lower than those in the control group (P 0.05). The total effective rate of the patients in the observation group was 96.50, which was significantly higher than that in the control group (78.18). The total incidence of adverse reactions in the control group was 10.91 and that in the observation group was 17.54%. There was no significant difference between the two groups (P 0.05). Conclusion the therapeutic effect of traditional Chinese medicine combined with glucosamine hydrochloride in the treatment of KOA with Yang deficiency and cold coagulation is obvious. Can improve knee joint function and inflammatory reaction better, safe and reliable, worth popularizing.
【作者單位】： 鄭州大學(xué)附屬南陽市中心醫(yī)院腎病風(fēng)濕免疫科;鄭州大學(xué)附屬南陽市中心醫(yī)院骨二科;鄭州大學(xué)附屬南陽市中心醫(yī)院中醫(yī)科;南陽理工學(xué)院張仲景國醫(yī)學(xué)院;
【分類號】：R684.3
【正文快照】： 膝關(guān)節(jié)骨性關(guān)節(jié)炎(knee osteoarthritis,KOA)又稱為退行性關(guān)節(jié)病,是一種以關(guān)節(jié)疼痛、腫脹為主要臨床表現(xiàn)的骨關(guān)節(jié)疾病,多見于中老年女性。我國發(fā)病率為50.00%~80.00%,且隨年齡升高發(fā)病率呈現(xiàn)逐漸升高趨勢[1]。KOA的治療藥物較多,環(huán)氧化酶-2(cyclooxygenase-2,COX-2)抑制劑、糖，

本文編號：1466665