【摘要】：目的探討和觀察中空羥基磷灰石復(fù)合rhBMP-2在骨缺損修復(fù)過(guò)程的再血管化。方法將48只成年的新西蘭雄性大白兔制作成橈骨骨缺損模型,隨機(jī)分3組,各組分別植入以下材料:中空HA/rhBMP-2復(fù)合人工骨、單純中空HA人工骨、單純r(jià)hBMP-2。植入后于4、8、12、16周分別注射99mTc-MDP進(jìn)行放射性核素骨顯像并監(jiān)測(cè)骨缺損修復(fù)過(guò)程中再血管化情況,同時(shí)進(jìn)行大體、X線、組織學(xué)觀察。結(jié)果術(shù)后各時(shí)間段,中空HA/rhBMP-2復(fù)合人工骨組在X線及放射性核素聚集強(qiáng)度明顯高于單純中空HA人工骨組(P0.05),表現(xiàn)為成骨代謝活躍及早期的再血管化能力。結(jié)論中空HA/rhBMP-2復(fù)合人工骨具有良好的骨缺損修復(fù)能力,成骨活性持久,再血管化能力強(qiáng),有望成為一種理想的骨缺損修復(fù)材料。
[Abstract]:Objective to investigate and observe the revascularization of hollow hydroxyapatite combined with rhBMP-2 in bone defect repair. Methods 48 adult New Zealand male white rabbits were randomly divided into three groups. The following materials were implanted in each group: hollow HA/rhBMP-2 composite artificial bone, simple hollow HA artificial bone and simple rhBMP-2.. At 4, 8, 12 and 16 weeks after implantation, 99mTc-MDP was injected with radionuclide bone imaging for radionuclide bone imaging and revascularization during bone defect repair was monitored, and gross, X-ray and histology were observed at the same time. Results at each time after operation, the aggregation intensity of X-ray and radionuclide in hollow HA/rhBMP-2 composite bone group was significantly higher than that in hollow HA artificial bone group (P 0.05), which showed active osteogenic metabolism and early revascularization ability. Conclusion Hollow HA/rhBMP-2 composite artificial bone has good bone defect repair ability, long osteogenic activity and strong revascularization ability, so it is expected to be an ideal bone defect repair material.
【作者單位】： 廣東醫(yī)學(xué)院附屬高明醫(yī)院骨二科;江西省人民醫(yī)院骨一科;
【分類號(hào)】：R318.08

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相關(guān)期刊論文 前3條

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本文編號(hào)：2506556