【摘要】：樹脂材料是口腔醫(yī)學(xué)臨床實踐中應(yīng)用最廣泛的一類醫(yī)學(xué)材料。由于口腔為有菌環(huán)境這一特殊性，樹脂材料的抗菌性能對于預(yù)防因細菌等微生物感染引起的口腔疾�。ㄈ琮x齒，牙周病，，口腔感染性粘膜病等）具有重要實際意義�？咕詷渲牧峡梢砸种苹蛘邭缯掣皆诓牧媳砻娴募毦韵蛘咭种茦渲牧媳砻嫖⑸锷锬さ男纬�。傳統(tǒng)抗菌性樹脂材料通常依賴抗菌成分釋放機制實現(xiàn)。但是，通過釋放機制的抗菌策略，在起始的“突釋期”（Burst-release Phase）內(nèi)可釋放足量的抗菌成分而獲得一定的抗菌效果。但是在隨后的尾期釋放（Tail-release Phase）中常常因為濃度太低難以達到有效抗菌濃度，同時可能誘導(dǎo)細菌耐受性。另外，材料中抗菌成分的釋放，最終可能導(dǎo)致材料機械性能的下降。 本論文報道利用凝膠-溶膠方法，合成一種可與甲基丙烯酸酯基樹脂材料共聚和的抗菌性單體：季銨甲基丙烯酰氧基硅酸鹽（QAMS）。在該合成體系前體物質(zhì)中，正硅酸四乙酯（TEOS）為“錨”分子，連接具有廣譜抗菌性能的三烷氧基硅烷SiQAC和具甲基丙烯酸酯基的3-MPTS。通過調(diào)整反應(yīng)體系的pH和水含量，可控制QAMS的水解和縮合反應(yīng)動力，以滿足不同材料應(yīng)用需求。將部分水解的QAMS-3PH整合入bis-GMA樹脂系統(tǒng)后，bis-GMA/QAMS-3PH樹脂材料具有對變形鏈球菌，內(nèi)氏放線菌和白色念珠菌具有良好的抗菌效果；同時，樹脂材料在水老化后，通過QAMS-3PH的繼續(xù)水解縮合，材料表現(xiàn)出抗斷裂性能的提升。全部水解的QAMS可溶解于MMA單體，從而整合于PMMA樹脂系統(tǒng)，該樹脂材料除表現(xiàn)出典型的長期接觸殺菌效果外，其斷裂韌度（Fracture Toughness）得到提升。最后，我們利用改良St ber方法，在水-乙醇反應(yīng)體系中，以氨水為催化劑，在沒有外加的表面活性劑的條件下，水解共聚合TEOS以及另外兩個三烷氧基硅烷：SiQAC和3-MPTS，合成倍半硅氧烷-二氧化硅雜化物（SqSH）顆粒。通過改變反應(yīng)前體物中TEOS與SiQAC/3-MPTS的比例，可得到不同彈性模量的SqSH顆粒。該顆粒除抗菌性能外，具有規(guī)則的板層狀結(jié)構(gòu)。
[Abstract]:Resin material is the most widely used medical material in clinical practice of stomatology. Because of the particularity of oral bacterial environment, the antibacterial properties of resin materials are of great practical significance for the prevention of oral diseases (such as dental caries, periodontal disease, oral infectious mucous membrane diseases, etc.) caused by microbial infections such as bacteria. Antibacterial resin materials can inhibit or kill bacteria attached to the surface of materials to eliminate or inhibit the formation of microbial membranes on the surface of resin materials. Traditional antibacterial resin materials usually rely on the release mechanism of antibacterial components. However, through the antibacterial strategy of release mechanism, a sufficient amount of antibacterial components can be released in the initial "sudden release period" (Burst-release Phase), and a certain antibacterial effect can be obtained. However, in the later release (Tail-release Phase), it is often difficult to reach the effective antibacterial concentration because the concentration is too low, and it may induce bacterial tolerance at the same time. In addition, the release of antibacterial components in the material may eventually lead to the decline of mechanical properties of the material. In this paper, a kind of antibacterial monomer, quaternary ammonium methacroloxy silicate (QAMS)., which can be synthesized by gel-sol method, which can be copolymerized with methacrylate based resin, is reported in this paper. In the precursor of the synthesis system, tetraethyl orthosilicate (TEOS) is an "anchor" molecule, which connects trialkoxysilane SiQAC with broad-spectrum antibacterial properties and 3 times MPTS with methacrylic group. By adjusting the pH and water content of the reaction system, the hydrolysis and condensation reaction kinetics of QAMS can be controlled to meet the application needs of different materials. After the partially hydrolyzed QAMS-3PH was integrated into the bis-GMA resin system, the bis-GMA/QAMS-3PH resin material had good antibacterial effect on Streptococcus mutans, Actinomyces nigris and candida albicans. At the same time, after water aging, through the continuous hydrolysis and condensation of QAMS-3PH, the fracture resistance of the resin material was improved. All the hydrolyzed QAMS can be dissolved in MMA monomer and thus integrated into PMMA resin system. In addition to the typical long-term contact germicidal effect, the fracture toughness (Fracture Toughness) of the resin material is improved. Finally, we used the improved St ber method to hydrolyze TEOS and two other trialkoxysilane: SiQAC and 3 / MPTS in the water-ethanol reaction system with ammonia water as catalyst and without additional surfactants. The (SqSH) particles of silsesquioxane-silica hybrid were synthesized. By changing the ratio of TEOS to SiQAC/3-MPTS in the reaction precursor, SqSH particles with different elastic modulus can be obtained. In addition to its antibacterial properties, the particles have a regular lamellar structure.
【學(xué)位授予單位】：華中科技大學(xué)
【學(xué)位級別】：博士
【學(xué)位授予年份】：2013
【分類號】：R783.1

【參考文獻】

相關(guān)期刊論文 前1條

1 王曉榮,葉湘玉,牛百平;青少年產(chǎn)生正畸治療需求動機的影響因素[J];實用口腔醫(yī)學(xué)雜志;1998年03期

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