【摘要】：左心室輔助裝置作為一款心室輔助裝置,已成為人們關(guān)注的焦點(diǎn)。目前國內(nèi)外對左心室磁懸浮輔助裝置的相關(guān)研究較多,溶血性能和血栓是評價(jià)血泵性能好壞的重要標(biāo)準(zhǔn),具備良好的溶血性能和較低的血栓發(fā)生率不僅可以提高輔助裝置的安全性,而且還能為研制永久性植入式左心室磁懸浮輔助裝置奠定基礎(chǔ)。本文以自主研發(fā)的左心室磁懸浮輔助泵為研究對象,利用計(jì)算流體力學(xué)模擬左心室磁懸浮輔助裝置內(nèi)部葉片與血液的耦合過程,研究葉片個(gè)數(shù)、葉片高度、懸浮高度,以及葉片轉(zhuǎn)速對血流動(dòng)力學(xué)的影響。應(yīng)用3D打印技術(shù)對設(shè)計(jì)裝置進(jìn)行加工制造并進(jìn)行實(shí)驗(yàn),為今后的相關(guān)實(shí)驗(yàn)研究提供參考了依據(jù)。理論研究結(jié)果表明:耦合過程中葉片的轉(zhuǎn)速對血泵出口流量和葉片壁面剪切應(yīng)力的影響最大,葉片個(gè)數(shù)和高度次之,懸浮高度最小;提高葉片轉(zhuǎn)速,葉片壁面最大剪切應(yīng)力和血泵出口平均流量將會(huì)增加;增加葉片個(gè)數(shù),葉片最大剪切應(yīng)力會(huì)出現(xiàn)增加的趨勢;增加葉片高度,葉片最大剪切應(yīng)力將減少,出口平均流量將增加;增加懸浮高度,葉片最大剪切應(yīng)力和出口平均流量均會(huì)減少;隨著懸浮高度增加,靠近葉片結(jié)構(gòu)間的主要流跡分布有減少的趨勢;隨著葉片高度增加,血流的主要流跡趨于規(guī)則化,沒有形成渦流區(qū)和回流區(qū),但葉片高度過高,血流流跡流經(jīng)葉片結(jié)構(gòu)根部的趨勢會(huì)逐漸減小,不利于防止血栓的產(chǎn)生;葉片轉(zhuǎn)速對血流流跡的分布影響較小。利用計(jì)算流體模擬仿真軟件對左心室磁懸浮輔助裝置進(jìn)行研究,揭示了血泵與血液相互作用的影響規(guī)律,為輔助裝置結(jié)構(gòu)優(yōu)化奠定了理論基礎(chǔ)。實(shí)驗(yàn)結(jié)果顯示,3D打印技術(shù)制造的輔助泵滿足了實(shí)驗(yàn)的需要,并為醫(yī)療領(lǐng)域應(yīng)用3D打印技術(shù)提供了一種新思路。
[Abstract]:As a ventricular auxiliary device, left ventricular auxiliary device has become the focus of attention. At present, there are many researches on left ventricular maglev auxiliary device at home and abroad. Hemolytic performance and thrombus are important standards to evaluate the performance of blood pump. Good hemolytic performance and low thrombus incidence can not only improve the safety of auxiliary device, but also lay a foundation for the development of permanent implantable left ventricular maglev auxiliary device. In this paper, the coupling process between blade and blood in left ventricular maglev auxiliary device is simulated by computational fluid dynamics (CFD), and the number of blades, blade height and suspension height are studied. And the effect of blade speed on hemodynamics. 3D printing technology is used to process and manufacture the design device and carry on the experiment, which provides a reference for the related experimental research in the future. The theoretical results show that the rotating speed of the blade has the greatest influence on the outlet flow rate of the blood pump and the shear stress on the blade wall, followed by the number and height of the blade, and the suspension height is the smallest. With the increase of blade speed, the maximum shear stress on the blade wall and the average flow rate at the outlet of the blood pump will increase, and the maximum shear stress of the blade will increase with the increase of the number of blades. With the increase of blade height, the maximum shear stress of blade will decrease and the average flow rate at outlet will increase, and with the increase of suspension height, the maximum shear stress and outlet average flow rate of blade will decrease. With the increase of suspension height, the distribution of main flow tracks near the blade structure tends to decrease. With the increase of blade height, the main flow trace of blood flow tends to be regular, and no vortex area and reflux area are formed, but when the blade height is too high, the trend of blood flow trace flow through the root of blade structure will gradually decrease, which is not conducive to preventing the formation of thrombus. The blade speed has little effect on the distribution of blood flow trace. The left ventricular maglev auxiliary device is studied by using computational fluid simulation software, and the influence law of the interaction between blood pump and blood is revealed, which lays a theoretical foundation for the structural optimization of the auxiliary device. The experimental results show that the auxiliary pump manufactured by 3D printing technology meets the needs of the experiment and provides a new idea for the application of 3D printing technology in medical field.
【學(xué)位授予單位】：內(nèi)蒙古工業(yè)大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R318.6;TP391.73

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