【摘要】：殼聚糖是甲殼素脫乙�；蟮漠a(chǎn)物,因分子中含有大量的氨基等生物官能團(tuán),使得殼聚糖容易進(jìn)行結(jié)構(gòu)修飾和改性。另外殼聚糖成膜性能良好,殼聚糖膜具有許多獨特的優(yōu)點,例如無毒、生物相容性且無抗原性、抑菌性、生物可降解性、吸濕性等,因而在醫(yī)用紡織品行業(yè)得到廣泛的應(yīng)用。但是目前全世界能夠生產(chǎn)使用的殼聚糖少、價格昂貴,大大限制了殼聚糖紡織品的生產(chǎn)和廣泛應(yīng)用。明膠是膠原水解的產(chǎn)物,是一種水溶性天然蛋白質(zhì),具有一系列優(yōu)異性能,如生物親和性、可降解性、生物相容性等,廣泛應(yīng)用于生物材料。利用明膠和殼聚糖共混制膜的方法是降低原料成本改善殼聚糖膜性能的一條重要途徑。 本文利用明膠對殼聚糖進(jìn)行交聯(lián)改性,利用流延法經(jīng)氫氧化鈉凝固浴對共混溶液進(jìn)行凝固制膜。首先,通過單因素實驗討論了殼聚糖／明膠共混比、凝固浴濃度、凝固時間、凝固浴溫度四個影響因素對殼聚糖-明膠共混膜物理機(jī)械性能的影響,并確定最佳單因素工藝參數(shù)。結(jié)果表明,最佳的共混比例為70/30、最佳凝固浴濃度為10%、最佳凝固時間為60s、最佳凝固浴溫度為30℃。其次,由單因素工藝參數(shù)確定水平數(shù)設(shè)計正交實驗方案,確定最佳的殼聚糖與明膠共混膜成型工藝條件。 對制備的一系列明膠改性殼聚糖膜進(jìn)行力學(xué)性能研究發(fā)現(xiàn),經(jīng)明膠改性后,膜的斷裂強度、斷裂伸長在一定范圍內(nèi)有所改善。對改性前后殼聚糖膜進(jìn)行紅外表征,討論改性膜內(nèi)部分子間的相互作用。通過X-射線衍射分析,明膠改性前后殼聚糖膜的結(jié)晶性能下降。試驗中通過SEM、FT-IR、XRD和DSC分析,顯示殼聚糖和明膠具有良好的相容性。對改性前后殼聚糖膜進(jìn)行溶脹性能測試和水溶性測試發(fā)現(xiàn),改性殼聚糖膜的溶脹度隨著明膠含量的增加先減小后增大；水溶性能則隨著明膠含量的增加而增大。 為了改善明膠-殼聚糖共混膜的水溶性,采用單寧作為反應(yīng)交聯(lián)劑制備得到單寧-明膠-殼聚糖復(fù)合膜。通過SEM、FT-IR、XRD和DSC對復(fù)合膜進(jìn)行結(jié)構(gòu)表征,研究了復(fù)合物的結(jié)構(gòu)以及復(fù)合物分子間的相互作用。對復(fù)合物進(jìn)行物理機(jī)械性能測試、溶脹性能測試和水溶性能測試,結(jié)果表明在對共混膜物理機(jī)械性能影響不大的情況下,復(fù)合膜的水溶性有明顯的降低。
[Abstract]:Chitosan is the product of chitin deacetylation. Because it contains a large number of amino groups, it is easy to modify and modify the structure of chitosan. Chitosan film has many unique advantages, such as non-toxicity, biocompatibility and no antigenicity, bacteriostatic, biodegradability, hygroscopicity and so on, so it has been widely used in medical textile industry. However, at present, chitosan can be produced and used all over the world, which greatly limits the production and wide application of chitosan textiles because of its low cost and high price. Gelatin is a product of collagen hydrolysis, is a water-soluble natural protein, has a series of excellent properties, such as bioaffinity, biocompatibility, and so on, widely used in biomaterials. It is an important way to reduce the raw material cost to improve the performance of chitosan film by blending gelatin and chitosan. In this paper, chitosan was crosslinked by gelatin and solidified in sodium hydroxide coagulation bath by flow casting method. Firstly, the effects of four factors, such as chitosan / gelatin blending ratio, coagulation bath concentration, solidification time and coagulation bath temperature, on the physical and mechanical properties of chitosan-gelatin blend film were discussed by single factor experiment. The optimum single factor process parameters were determined. The results showed that the optimum blending ratio was 70 渭 30, the optimum coagulation bath concentration was 10%, the optimal solidification time was 60 s, and the optimum coagulation bath temperature was 30 鈩，

本文編號：2437631