【摘要】：背景:心肌肥大、椎間盤退行性疾病等疾病的發(fā)生與其組織細胞所處力學(xué)環(huán)境密切相關(guān),而自噬在這些疾病的發(fā)病過程起到重要作用。目的:綜述力學(xué)因素對不同組織細胞自噬的影響及其涉及的分子機制,為自噬的研究及相關(guān)疾病的預(yù)防治療提供參考作用。方法:檢索2000至2016年Web of Science和Pub Med數(shù)據(jù)庫中關(guān)于力學(xué)因素對細胞自噬影響的文獻,英文檢索詞為"autophagy,mechanical",進行系統(tǒng)的歸納總結(jié)和分析,排除內(nèi)容相關(guān)性差或重復(fù)文獻,最終得到52篇文獻。結(jié)果與結(jié)論:(1)力學(xué)因素對心肌細胞、內(nèi)皮細胞、軟骨細胞、骨骼肌細胞等多種細胞的自噬產(chǎn)生影響,細胞自噬是細胞應(yīng)對刺激的一種自我保護性反應(yīng),在受到生理水平的力學(xué)刺激時,細胞上調(diào)自噬水平,維持細胞的穩(wěn)態(tài)、功能以及存活;(2)力學(xué)因素可能通過PI3K-AKT-mTOR、氧自由基、AKT-FoxO等通路引起細胞自噬,具體機制有待進一步研究。
[Abstract]:Background: myocardial hypertrophy, intervertebral disc degeneration and other diseases are closely related to the mechanical environment in which the tissue cells are located. Autophagy plays an important role in the pathogenesis of these diseases. Aim: to review the effects of mechanical factors on autophagy in different tissues and its molecular mechanisms, and to provide reference for the study of autophagy and the prevention and treatment of related diseases. Methods: literature on the effect of mechanical factors on autophagy was searched in Web of Science and Pub Med databases from 2000 to 2016. The English key word was "autophagy,mechanical". Finally, 52 papers were obtained. Results and conclusion: (1) Mechanical factors have an effect on autophagy of cardiomyocytes, endothelial cells, chondrocytes, skeletal muscle cells, etc. Autophagy is a self-protective response of cells to stimulation. When stimulated by mechanical stimulation of physiological level, the cells upregulated autophagy level and maintained the homeostasis, function and survival of the cells. (2) Mechanical factors may induce autophagy through PI3K-AKT-mTOR, oxygen free radical and AKT-FoxO pathway.
【作者單位】： 北京航空航天大學(xué)生物與醫(yī)學(xué)工程學(xué)院生物力學(xué)與力生物學(xué)教育部重點實驗室;
【基金】：國家自然科學(xué)基金(11572030)~~
【分類號】：R318.01

【相似文獻】

相關(guān)期刊論文 前2條

1 孫軻婧;鄭芳;溫龍平;;三種納米材料C_(70),C_(60)Cl_6和C_(60)Ph_6引起細胞自噬的現(xiàn)象[J];中國科學(xué)技術(shù)大學(xué)學(xué)報;2010年04期

2 ;[J];;年期

，

本文編號：2371221