【摘要】：利用真空高溫退火技術(shù)制備不同退火溫度的Ti-O粉末、X線衍射儀、Zeta電位和比表面積等表征材料,采用Bradford法測纖維蛋白原在其表面的吸附解吸附行為,運用紅外線光譜分析纖維蛋白原在其表面吸附后二級結(jié)構(gòu)的變化,用流式細(xì)胞儀研究其對血小板的激活程度.研究表明,800℃高溫退火使得Ti-O粉末由銳鈦礦轉(zhuǎn)化為金紅石,比表面積減少10倍,攜帶有更多的負(fù)電荷;吸附血漿纖維蛋白原的數(shù)量減少到67μg,且維持原有的二級結(jié)構(gòu),并存在較大的解吸附;不易引起血小板的激活,具有更好的血液相容性.
[Abstract]:Ti-O powder X-ray diffractometer with different annealing temperature was prepared by vacuum high temperature annealing. The adsorption and desorption behavior of fibrinogen on its surface was measured by Bradford method. The changes of the secondary structure of fibrinogen adsorbed on the surface of fibrinogen were analyzed by infrared spectroscopy, and the activation degree of fibrinogen on platelets was studied by flow cytometry. The results showed that the Ti-O powder changed from anatase to rutile after high temperature annealing at 800 鈩，

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