【摘要】：背景:隨著材料學的不斷發(fā)展,鎂合金血管支架材料在心血管疾病中廣泛運用,但是傳統(tǒng)合金材料難以滿足血管支架要求,因此采取有效措施完成支架表面改性,提高血管支架的組織、力學性能具有深遠的意義。目的:觀察血管支架在快速凝固Mg-Zn-Y-Nd合金中的組織學及表面改性情況。方法:選擇具備良好力學性能、耐腐蝕性能的低鋅系Mg-2Zn-0.2Y合金為基本材料,向材料中加入Nd,Zn元素完成合金支架的細化;經(jīng)過對支架的擠壓細化組織性能完成支架表面改性,提高合金材料的綜合性能,獲得血管支架用新型鎂合金并完成支架表面改性。通過金相顯微組織、掃描電鏡能譜及射線衍射分析實驗了解制備支架的組織性能;通過硬度、拉伸實驗了解支架的力學性能。結(jié)果與結(jié)論:(1)金相顯微鏡組織觀察結(jié)果顯示:當不加入Y時,鎂合金支架第2相為桿狀,存在少許顆粒嵌入在基體中;當向鎂合金支架中混入0.5%Y元素時,支架第2相中桿狀物明顯減少,以顆粒狀為主,且均勻分布在機體中;加入1.0%的Y時,第2相數(shù)增加,晶粒中可見大量枝晶,第2相存在不連續(xù)桿狀物;加入1.5%的Y時,合金組織中的大枝晶與局枝晶混合,第2相為桿狀。(2)射線衍射分析實驗結(jié)果表面:Mn-Zn-0.5Nd合金與Mn-Zn-1.0Nd合金中均含有相同的相(Mg4Zn7和(Nd,Y)2Zn17相)。當Nd濃度提高為1%時,合金中出現(xiàn)新的MgZ n2相;(3)鎂合金改性材料SEM及EDS實驗結(jié)果顯示:鎂合金改性后第2相中含有Zn元素、Nd及Y元素,并且Nd元素、Y元素含量和與Zn含量較接近。EDS分析可知:加入Zr元素后層片狀第2相中Zn元素水平明顯下降,Y元素、Nd元素含量提高,能獲得更加穩(wěn)定的性能;(4)顯微硬度實驗結(jié)果顯示:隨著鎂合金含量的不斷增加,合金顯微硬度值不斷增加;(5)拉伸實驗結(jié)果顯示:Mg-Zn-Y-0.5Nd-Zr支架的抗拉強度、屈服強度,顯著高于Mg-Zn-Y-0.5Nd,Mg-Zn-Y-1.0Nd,Mg-Zn-Y-1.0Nd-Zr(P0.05);Mg-Zn-Y-0.5Nd-Zr,Mg-Zn-Y-1.0Nd-Zr伸長率,高于Mg-Zn-Y-0.5Nd,Mg-Zn-Y-1.0Nd(P0.05)。(6)結(jié)果說明:選擇低鋅系Mg-2Zn-0.2Y合金為核心材料,向材料中分別加入Nd,Zn等微量元素,完成材料的改性,并且經(jīng)過對支架的擠壓細化組織性能完成支架表面改性,改性后材料具有優(yōu)良的性能。
[Abstract]:Background: with the development of material science, magnesium alloy vascular stent materials are widely used in cardiovascular diseases, but traditional alloy materials can not meet the requirements of vascular stent. Therefore, effective measures are taken to complete the surface modification of the stent. It is of great significance to improve the tissue and mechanical properties of vascular stent. Aim: to observe the histological and surface modification of vascular stent in rapidly solidified Mg-Zn-Y-ND alloy. Methods: low zinc system Mg-2Zn-0.2Y alloy with good mechanical properties and corrosion resistance was selected as the basic material, and the alloy bracket was refined by adding Ndzn Zn element to the material, and the surface modification of the scaffold could be completed by extrusion refinement of the scaffold. To improve the comprehensive properties of the alloy, a new type of magnesium alloy for vascular stent was obtained and the surface modification of the stent was completed. The microstructure and properties of the scaffold were studied by metallographic microstructure, SEM and XRD, and the mechanical properties of the scaffold were studied by hardness and tensile test. Results and conclusions: (1) the microstructure of magnesium alloy scaffolds showed that the second phase of magnesium alloy scaffolds was rod-like and a few particles were embedded in the matrix when Y was not added, and 0.5% Y element was added to the scaffolds. In the second phase of the scaffold, the number of the second phase was increased, and a large number of dendrites were observed in the second phase, and the second phase had discontinuous bar, and when 1.5% Y was added, there was a large number of dendrites in the second phase. The second phase is rod-like. (2) the results of X-ray diffraction analysis show that there are the same phases (Mg4Zn7 and (NdY) 2Zn17) in the surface of Mn-Zn-0.5Nd alloy and Mn-Zn-1.0ND alloy. When the concentration of ND is increased to 1, a new MgZ N2 phase appears in the alloy. (3) the SEM and EDS results of the modified magnesium alloy show that Zn elements ND and Y are present in the second phase of the modified magnesium alloy. The results of EDS analysis show that the content of Zn in the second phase of lamellar layer decreases obviously after the addition of Zr element, and the content of ND in Y element increases obviously after addition of Zr element, and the content of Y element in ND element is close to that of Zn element, which is similar to that of Zn element. (4) the results of microhardness test showed that the microhardness value of the alloy increased with the increasing of magnesium alloy content, (5) the tensile test results showed that the tensile strength and yield strength of the W Mg-Zn-Y-0.5Nd-Zr scaffold were increased. The results showed that Mg-Zn-Y-1.0Nd-Zr (P0.05) and Mg-Zn-Y-0.5Nd-ZrMg-Zn-Y-1.0Nd-Zr (P05) were higher than Mg-Zn-Y-0.5NdCU Mg-Zn-Y-1.0ND (P0.05). (6). The results showed that Mg-Zn-Y-1.0Nd-Zr (Mg-Zn-1.0Nd-Zr) alloy with low zinc content as the core material was modified by adding trace elements such as Ndzn Zn into the material. The surface of the scaffold can be modified by extruding and refining the microstructure of the scaffold, and the modified material has excellent properties.
【作者單位】： 河南大學淮河醫(yī)院;
【基金】：河南省科技攻關項目(2013HN01106)~~
【分類號】：R318.08;R54

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