本文選題：便攜 + 直流電刺激�。� 參考：《電子科技大學(xué)》2017年碩士論文

【摘要】：神經(jīng)系統(tǒng)類疾病是世界上發(fā)病率、致殘率、死亡率非常高的疾病。如何更有效地治療神經(jīng)系統(tǒng)疾病,減少患者的痛苦及提高患者的生活質(zhì)量已成為神經(jīng)科學(xué)領(lǐng)域研究的熱門話題。目前許多研究表明,經(jīng)顱直流電刺激對神經(jīng)系統(tǒng)類疾病的臨床治療具有積極的效果。國外得到最廣泛應(yīng)用的是德國NeuroConn公司和美國Soterix公司的經(jīng)顱直流電刺激產(chǎn)品,但是國內(nèi)還沒有專業(yè)的經(jīng)顱直流電刺激產(chǎn)品。NeuroConn公司和Soterix公司已合作研發(fā)一套便攜式經(jīng)顱電刺激產(chǎn)品,但是刺激參數(shù)必須連接電腦才可調(diào)并且沒有充電接口,因此本論文自主研究并設(shè)計了一套低功耗、可充電、刺激參數(shù)數(shù)字可調(diào)、多種刺激模式、安全可靠的便攜式經(jīng)顱直流電刺激系統(tǒng)。本文研制出的經(jīng)顱直流電刺激系統(tǒng)主要由硬件電路和人機(jī)交互界面組成。硬件電路設(shè)計包括設(shè)計具有數(shù)字可調(diào)的電流源電路、實時監(jiān)控的過流保護(hù)電路和高精度的阻抗檢測電路。電流源電路是整個經(jīng)顱直流電刺激系統(tǒng)的基礎(chǔ),電流輸出在0~1mA范圍內(nèi)時誤差小于20μA,電流輸出在1mA~2mA范圍內(nèi)時誤差小于50μA,數(shù)字最小可調(diào)步長為50μA。過流保護(hù)電路能夠?qū)崟r監(jiān)控刺激電流幅度,來保證刺激電流在人體安全閾值內(nèi)。阻抗檢測電路的功能是檢測電極與頭皮的接觸狀態(tài),系統(tǒng)的阻抗檢測在3.92kΩ以下,其誤差低至70Ω。另外,經(jīng)顱直流電刺激系統(tǒng)具有自動增減功能,當(dāng)電流幅度設(shè)置前后變化時,系統(tǒng)會根據(jù)之前電流幅度逐漸增減到之后的設(shè)定值。因此,用戶不會因為刺激期間電流幅度劇烈變化,而感到刺痛感。另外,系統(tǒng)樣機(jī)的最大功耗約為600mW,可以連續(xù)工作12個小時。本文經(jīng)過系統(tǒng)方案設(shè)計、各模塊電路設(shè)計、PCB制板、系統(tǒng)軟硬件調(diào)試后對樣機(jī)各項參數(shù)進(jìn)行測試,符合人體電氣安全標(biāo)準(zhǔn)。另外,本文利用研制的樣機(jī)進(jìn)行了經(jīng)顱直流電刺激健康人體實驗,分析了經(jīng)顱直流電刺激樣機(jī)的刺激效果,驗證了經(jīng)顱直流電刺激樣機(jī)的有效性和可靠性。本論文設(shè)計的便攜式經(jīng)顱直流電刺激樣機(jī)可以為神經(jīng)系統(tǒng)疾病的臨床實驗與治療提供一個較好的電刺激系統(tǒng)平臺。
[Abstract]:Neurological diseases are very high morbidity, disability and mortality in the world. How to treat nervous system diseases more effectively, reduce the suffering of patients and improve the quality of life of patients has become a hot topic in the field of neuroscience. At present, many studies have shown that transcranial direct current stimulation has a positive effect on the clinical treatment of nervous system diseases. The most widely used products abroad are transcranial direct current stimulation products from NeuroConn of Germany and Soterix of the United States. However, there is no professional transcranial direct current stimulation product in China. NeuroConn and Soterix have developed a portable transcranial direct current stimulation product. However, the stimulation parameters must be connected to the computer to adjust and have no charging interface. Therefore, this paper has independently studied and designed a set of low power consumption, rechargeable, digital adjustable stimulus parameters and various stimulation modes. Safe and reliable portable transcranial direct current stimulation system. The transcranial direct current stimulation system is mainly composed of hardware circuit and man-machine interface. The hardware circuit design includes the design of a digital adjustable current source circuit, a real-time monitoring overcurrent protection circuit and a high precision impedance detection circuit. The current source circuit is the basis of the whole transcranial direct current stimulation system. The current output error is less than 20 渭 A in the 0~1mA range, the current output error is less than 50 渭 A in the 1mA~2mA range, and the minimum adjustable step size is 50 渭 A. Over-current protection circuit can monitor the amplitude of stimulus current in real time to ensure that the stimulation current is within the human safety threshold. The function of the impedance detection circuit is to detect the contact state between the electrode and the scalp. The impedance detection of the system is below 3.92 k 惟, and the error is as low as 70 惟. In addition, the transcranial direct current stimulation system has the function of automatic increase and decrease. When the current amplitude changes before and after the current amplitude is set, the system will gradually increase and decrease to the following set value according to the previous current amplitude. Therefore, users will not feel tingling because of the sharp changes in the magnitude of the current during the stimulation. In addition, the maximum power consumption of the system prototype is about 600 MW, which can work for 12 hours. After the design of the system scheme and the circuit design of each module, the PCB board is designed. After debugging the hardware and software of the system, the parameters of the prototype are tested, which conforms to the human body electrical safety standard. In addition, the experimental results of transcranial direct current (TDC) stimulation in healthy volunteers were carried out by using the prototype, and the effectiveness and reliability of the TDCS prototype were analyzed, and the validity and reliability of the TDC prototype were verified. The portable transcranial direct current electrical stimulation prototype designed in this paper can provide a good platform for the clinical experiment and treatment of nervous system diseases.
【學(xué)位授予單位】：電子科技大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R741;TH789

【參考文獻(xiàn)】

相關(guān)期刊論文 前1條

1 劉盼;劉世文;;經(jīng)顱直流電刺激的研究及應(yīng)用[J];中國組織工程研究與臨床康復(fù);2011年39期

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本文編號：2075552