本文選題：組織工程 + 快速原型技術(shù)　； 參考：《東北大學(xué)》2012年碩士論文

【摘要】：人體組織損傷、缺損會(huì)導(dǎo)致功能障礙。傳統(tǒng)的修復(fù)方法是自體組織移植術(shù),雖然可以取得滿意療效,但它是以犧牲自體健康組織為代價(jià)的辦法,會(huì)導(dǎo)致很多并發(fā)癥及附加損傷；人的器官功能衰竭,采用藥物治療、暫時(shí)性替代療法可挽救部分病人生命,但供體器官來(lái)源極為有限,因免疫排斥反應(yīng)需長(zhǎng)期使用免疫抑制劑,由此而帶來(lái)的并發(fā)癥有時(shí)是致命的。自80年代科學(xué)家首次提出“組織工程學(xué)”概念以后,為眾多的組織缺損、器官功能衰竭病人的治療帶來(lái)了曙光。 組織工程學(xué)是由美國(guó)國(guó)家科學(xué)基金委員會(huì)于1987年正式提出和確定的,是應(yīng)用細(xì)胞生物學(xué)、生物材料和工程學(xué)的原理,研究開發(fā)用于修復(fù)或改善人體病損組織或器官的結(jié)構(gòu)、功能的生物活性替代物的一門科學(xué)。 本課題是基于組織工程學(xué)和快速原型技術(shù)對(duì)下頜骨腫瘤病變手術(shù)過程中所需的假體替代物設(shè)計(jì)以及制造技術(shù)的研究。針對(duì)于組織工程學(xué)的概念,本課題提出了通過逆向工程,UG二次開發(fā)以及生物醫(yī)用材料等方法來(lái)實(shí)現(xiàn)假體替代物的制造。本課題的研究?jī)?nèi)容有以下四個(gè)方面： 1、搜集患者的CT數(shù)據(jù)信息,根據(jù)CT圖像應(yīng)用醫(yī)學(xué)軟件(Mimics10.01)和逆向軟件(Geomagic Studio10)對(duì)骨骼外形進(jìn)行逆向建模,盡量還原患者下頜骨的真實(shí)三維模型,為下面人工骨組織造型技術(shù)研究減小誤差,打下良好的基礎(chǔ)。 2、通過對(duì)疾病發(fā)病機(jī)理和常見發(fā)病位置以及骨組織內(nèi)部微細(xì)結(jié)構(gòu)的了解,并根據(jù)三維模型以及常見病區(qū)位置利用UG截取適當(dāng)?shù)奶鎿Q位置,并且簡(jiǎn)化裁剪的模型形狀,總結(jié)國(guó)內(nèi)外的人工骨組織模型內(nèi)部結(jié)構(gòu),提出筆者自己的建模思想。 3、學(xué)習(xí)UG二次開發(fā)語(yǔ)言,在UG高級(jí)仿真模塊劃分六面體網(wǎng)格并提取節(jié)點(diǎn)和連接單元信息。利用UG Open GRIP和C++語(yǔ)言混合編程,并且以GRIP實(shí)現(xiàn)核心建模過程,用編程的方法構(gòu)造出人工骨組織內(nèi)部三維模型,提高建模效率。 4、利用快速原型技術(shù)的理論,將前述模型加工成實(shí)體,并且以前述的模型作為模具,以羥基磷灰石作為假體材料,制造出生物活性材料的人工假體。
[Abstract]:Damage to human tissues and defects can lead to dysfunction. The traditional method of repair is autogenous tissue transplantation. Although it can achieve satisfactory results, it is a method at the expense of self-healthy tissue, which can lead to many complications and additional injuries. Temporary replacement therapy can save some patients' lives, but the donor organ source is very limited, and the complications are sometimes fatal because of the long-term use of immunosuppressive agents for immune rejection. Since the concept of "tissue engineering" was first put forward by scientists in 1980's, it has brought light to the treatment of many patients with tissue defects and organ failure. Tissue engineering was formally proposed and determined by the National Science Foundation Committee of the United States in 1987. It applies the principles of cell biology, biomaterials and engineering to research and development of structures used to repair or improve human diseased tissues or organs. A science of functional bioactive substitutes. This paper is based on tissue engineering and rapid prototyping technology to study the design and manufacture of prosthetic substitutes needed in mandibular tumor surgery. In view of the concept of tissue engineering, this paper proposes a method to manufacture prosthetic substitutes by reverse engineering and secondary development of UG and biomedical materials. The research contents of this paper are as follows: 1. Collecting CT data information of patients, according to CT image application medical software (Mimics 10.01) and reverse software (Geomagic Studio 10) to carry out reverse modeling of bone shape. Try to reduce the true three-dimensional model of the patient's mandible, so as to reduce the error for the following artificial bone tissue modeling technology. 2. Through the understanding of the pathogenesis of the disease, the common location of the disease and the internal fine structure of bone tissue, according to the 3D model and the location of the common disease area, the appropriate replacement position was obtained by UG. And simplify the shape of cutting model, summarize the internal structure of artificial bone tissue model at home and abroad, put forward the author's own modeling idea. 3, learn UG secondary development language, The advanced simulation module of UG is divided into hexahedron mesh and the information of node and connection unit is extracted. Using UG Open grip and C language mixed programming, and using grip to realize the core modeling process, using programming method to construct the internal three-dimensional model of artificial bone tissue, to improve the efficiency of modeling. 4. The theory of rapid prototyping technology is used to construct the internal three-dimensional model of artificial bone tissue. The model is processed into an entity and the model is used as a mold and hydroxyapatite is used as a prosthetic material to produce an artificial prosthesis of bioactive material.
【學(xué)位授予單位】：東北大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類號(hào)】：R318.08;R687

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 姜睿智;岳秀艷;史廷春;邱建輝;索海瑞;彭東亮;;面向RP的CT圖像處理技術(shù)綜述[J];CT理論與應(yīng)用研究;2008年01期

2 馬武秀;程迅生;;自體骨移植修復(fù)骨缺損的研究進(jìn)展[J];中國(guó)骨與關(guān)節(jié)損傷雜志;2011年06期

3 吳林波,丁建東;組織工程三維多孔支架的制備方法和技術(shù)進(jìn)展[J];功能高分子學(xué)報(bào);2003年01期

4 何斌,金永杰,李玉蘭;按照DICOM標(biāo)準(zhǔn)制定核醫(yī)學(xué)圖像文件格式[J];核電子學(xué)與探測(cè)技術(shù);2001年06期

5 趙劍;謝宗蕻;安學(xué)峰;張明;劉剛;馬宏毅;;蜂窩芯體材料面外等效彈性模量預(yù)測(cè)與分析[J];航空材料學(xué)報(bào);2008年04期

6 彭育輝;高誠(chéng)輝;何炳蔚;;反求工程與快速原型制造集成方法的分析與比較[J];機(jī)械研究與應(yīng)用;2007年01期

7 李莉敏,郭桂芳,胡慶夕,吳懋亮;面向骨組織工程的三維仿生支架的微觀結(jié)構(gòu)研究[J];中國(guó)制造業(yè)信息化;2005年04期

8 紀(jì)鋼;張建勛;;CT中的DICOM圖像處理技術(shù)[J];計(jì)算機(jī)應(yīng)用與軟件;2007年10期

9 張永剛;;有限元法發(fā)展及其應(yīng)用[J];科技情報(bào)開發(fā)與經(jīng)濟(jì);2007年11期

10 陳晨;曹學(xué)成;桑成林;左貴來(lái);陳琳;;同種異體骨移植治療大段骨缺損的研究進(jìn)展[J];現(xiàn)代生物醫(yī)學(xué)進(jìn)展;2010年22期

，

本文編號(hào)：2051765