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  本文選題：組織工程 + 快速原型技術��； 參考：《東北大學》2012年碩士論文

【摘要】：人體組織損傷、缺損會導致功能障礙。傳統(tǒng)的修復方法是自體組織移植術,雖然可以取得滿意療效,但它是以犧牲自體健康組織為代價的辦法,會導致很多并發(fā)癥及附加損傷；人的器官功能衰竭,采用藥物治療、暫時性替代療法可挽救部分病人生命,但供體器官來源極為有限,因免疫排斥反應需長期使用免疫抑制劑,由此而帶來的并發(fā)癥有時是致命的。自80年代科學家首次提出“組織工程學”概念以后,為眾多的組織缺損、器官功能衰竭病人的治療帶來了曙光。 組織工程學是由美國國家科學基金委員會于1987年正式提出和確定的,是應用細胞生物學、生物材料和工程學的原理,研究開發(fā)用于修復或改善人體病損組織或器官的結構、功能的生物活性替代物的一門科學。 本課題是基于組織工程學和快速原型技術對下頜骨腫瘤病變手術過程中所需的假體替代物設計以及制造技術的研究。針對于組織工程學的概念,本課題提出了通過逆向工程,UG二次開發(fā)以及生物醫(yī)用材料等方法來實現假體替代物的制造。本課題的研究內容有以下四個方面： 1、搜集患者的CT數據信息,根據CT圖像應用醫(yī)學軟件(Mimics10.01)和逆向軟件(Geomagic Studio10)對骨骼外形進行逆向建模,盡量還原患者下頜骨的真實三維模型,為下面人工骨組織造型技術研究減小誤差,打下良好的基礎。 2、通過對疾病發(fā)病機理和常見發(fā)病位置以及骨組織內部微細結構的了解,并根據三維模型以及常見病區(qū)位置利用UG截取適當的替換位置,并且簡化裁剪的模型形狀,總結國內外的人工骨組織模型內部結構,提出筆者自己的建模思想。 3、學習UG二次開發(fā)語言,在UG高級仿真模塊劃分六面體網格并提取節(jié)點和連接單元信息。利用UG Open GRIP和C++語言混合編程,并且以GRIP實現核心建模過程,用編程的方法構造出人工骨組織內部三維模型,提高建模效率。 4、利用快速原型技術的理論,將前述模型加工成實體,并且以前述的模型作為模具,以羥基磷灰石作為假體材料,制造出生物活性材料的人工假體。
[Abstract]:Damage to human tissues and defects can lead to dysfunction. The traditional method of repair is autogenous tissue transplantation. Although it can achieve satisfactory results, it is a method at the expense of self-healthy tissue, which can lead to many complications and additional injuries. Temporary replacement therapy can save some patients' lives, but the donor organ source is very limited, and the complications are sometimes fatal because of the long-term use of immunosuppressive agents for immune rejection. Since the concept of "tissue engineering" was first put forward by scientists in 1980's, it has brought light to the treatment of many patients with tissue defects and organ failure. Tissue engineering was formally proposed and determined by the National Science Foundation Committee of the United States in 1987. It applies the principles of cell biology, biomaterials and engineering to research and development of structures used to repair or improve human diseased tissues or organs. A science of functional bioactive substitutes. This paper is based on tissue engineering and rapid prototyping technology to study the design and manufacture of prosthetic substitutes needed in mandibular tumor surgery. In view of the concept of tissue engineering, this paper proposes a method to manufacture prosthetic substitutes by reverse engineering and secondary development of UG and biomedical materials. The research contents of this paper are as follows: 1. Collecting CT data information of patients, according to CT image application medical software (Mimics 10.01) and reverse software (Geomagic Studio 10) to carry out reverse modeling of bone shape. Try to reduce the true three-dimensional model of the patient's mandible, so as to reduce the error for the following artificial bone tissue modeling technology. 2. Through the understanding of the pathogenesis of the disease, the common location of the disease and the internal fine structure of bone tissue, according to the 3D model and the location of the common disease area, the appropriate replacement position was obtained by UG. And simplify the shape of cutting model, summarize the internal structure of artificial bone tissue model at home and abroad, put forward the author's own modeling idea. 3, learn UG secondary development language, The advanced simulation module of UG is divided into hexahedron mesh and the information of node and connection unit is extracted. Using UG Open grip and C language mixed programming, and using grip to realize the core modeling process, using programming method to construct the internal three-dimensional model of artificial bone tissue, to improve the efficiency of modeling. 4. The theory of rapid prototyping technology is used to construct the internal three-dimensional model of artificial bone tissue. The model is processed into an entity and the model is used as a mold and hydroxyapatite is used as a prosthetic material to produce an artificial prosthesis of bioactive material.
【學位授予單位】：東北大學
【學位級別】：碩士
【學位授予年份】：2012
【分類號】：R318.08;R687

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本文編號：2051765