本文選題：西羅莫司藥物洗脫支架 + 永久聚合物��； 參考：《大連醫(yī)科大學》2012年碩士論文

【摘要】：研究背景：自第二代藥物洗脫支架的應用以來，爭論日益激烈。幾項大規(guī)模隨機實驗已經(jīng)證實了新型藥物洗脫支架的安全性及有效性。Partner支架（涂有永久性聚合物）和Excel支架（涂有生物可降解聚合物）是兩種不同類型由中國生產(chǎn)的西羅莫司洗脫支架。中期和長期療效已經(jīng)被研究并證實有前景，然而，遠期療效還不清楚。本研究旨在研究在現(xiàn)行臨床實踐中，這兩種類型藥物洗脫支架的遠期效果。 方法：本研究入選自2006年12月至2011年12月就診于大連醫(yī)科大學附屬第二醫(yī)院，，行PCI治療植入Partner或Excel支架的病人。病人根據(jù)植入支架的類型進行分組，并回顧性收集臨床危險因素，同時進行隨訪。比較隨訪60個月主要不良心血管事件和支架內(nèi)血栓形成的發(fā)生率（主要不良心血管事件：猝死，心肌梗死，靶血管重建） 結(jié)果：447例病人應用Partner支架，536例病人應用Excel支架，161例病人同時應用Partner和Excel支架。隨訪60個月MACE的發(fā)生率Partner組7.6%,Excel組6.9%(HR0.901, CI0.56-1.46, P=0.671)。心源性死亡、心肌梗死、靶血管重建的發(fā)生率分別為：2.2%versus1.7%(HR0.746, CI0.3-1.8, P=0.527),2.23%versus2.61%(HR1.17, CI0.51-2.7, P=0.705) and2.68%versus1.42%(HR0.55, CI0.223-1.365, P=0.187)。支架內(nèi)血栓形成的發(fā)生率0.44%versus0.74%（HR1.67,CI0.305-9.17, P=0.549）. 結(jié)論：多聚物涂層可降解Excel藥物洗脫支架和永久性涂層多聚物Partner支架真實世界中、遠期MACE和支架內(nèi)血栓形成的發(fā)生率較低。兩種藥物洗脫支架都可以安全有效地用于臨床以改善遠期預后。
[Abstract]:Background: since the application of the second generation drug eluting stent, the controversy has become increasingly fierce. Several large scale randomized trials have confirmed the safety and effectiveness of new drug-eluting stents. Partner stents (coated with permanent polymers) and Excel stents (coated with biodegradable polymers) are two different types of drug-eluting stents from China Sirolimus eluting stent. Medium-and long-term outcomes have been studied and proven promising, however, long-term outcomes are unclear. The aim of this study was to study the long-term effects of these two drug-eluting stents in current clinical practice. Methods: patients with partner or Excel stents were enrolled in the second affiliated Hospital of Dalian Medical University from December 2006 to December 2011. Patients were grouped according to the type of stent implantation, and clinical risk factors were collected retrospectively and followed up. To compare the incidence of major adverse cardiovascular events and in-stent thrombosis (major adverse cardiovascular events: sudden death, myocardial infarction) at 60 months follow-up. Results: one hundred and forty-seven patients were treated with partner stents and 536 patients with Excel stents. 161 patients were treated with both partner and Excel stents. The incidence of Mace in partner group was 7.6g / min. The HR0.901in Excel group, 0.901in CI 0.56-1.46in group C, 0.671 in group C were followed up for 60 months. The incidences of cardiogenic death, myocardial infarction and target vessel reconstruction were: 1: 2.2 versus 1.7 and HR0.746, CI0.3-1.8, P0. 527 and 2.23versus 2.61HR1.17, CI0.51-2.7, P0. 705) and 2.68versus 1.42HR0.55, CI0.223-1.365, PJ 0.187. The incidence of thrombus in stent was 0.44 versus 0.74% HR1.67 CI 0.305-9.17, and Ph 0.549%. Conclusion: in the real world, the incidence of long-term Mace and in-stent thrombosis is lower in polymer coated biodegradable Excel drug-eluting stents and permanent coated polymer partner stents. Both drug eluting stents can be used safely and effectively to improve long-term prognosis.
【學位授予單位】：大連醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2012
【分類號】：R318.08

【共引文獻】

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