本文選題：聚四氟乙烯 + 人工血管��； 參考：《中國組織工程研究》2016年47期

【摘要】：背景:聚四氟乙烯人工血管是臨床常用的醫(yī)用材料,但其具體的基礎研究內容尚未完善。目的:觀察聚四氟乙烯人工血管對血小板聚集的作用及細胞相容性。方法:(1)對血小板聚集的作用:檢測聚四氟乙烯人工血管的凝血時間、復鈣時間。將生理鹽水、蒸餾水及聚四氟乙烯人工血管分別加入兔紅細胞懸液中,計算溶血率;(2)細胞生物相容性:將SD大鼠原代心肌細胞分別接種于普通玻璃爬片與聚四氟乙烯人工血管片上,3 d后,檢測細胞乳酸脫氫酶釋放;5 d后,檢測細胞增殖。結果與結論:(1)聚四氟乙烯人工血管對兔血的動態(tài)凝血時間、復鈣時間沒有影響;聚四氟乙烯人工血管的溶血率為2.3%;(2)與接種于普通玻璃爬片上的心肌細胞相比,接種于聚四氟乙烯人工血管片上的心肌細胞增殖及乳酸脫氫酶釋放無明顯變化;(3)結果表明,聚四氟乙烯人工血管血小板聚集無影響,具有良好的血液相容性與細胞相容性。
[Abstract]:Background: polytetrafluoroethylene (PTFE) prosthesis is a commonly used medical material, but its basic research content is not perfect. Objective: to observe the effect of polytetrafluoroethylene (PTFE) on platelet aggregation and its cytocompatibility. Methods the effect of 1) on platelet aggregation: the coagulation time and calcium recovery time of polytetrafluoroethylene (PTFE) artificial blood vessel were measured. Normal saline, distilled water and polytetrafluoroethylene (PTFE) artificial blood vessels were added to rabbit erythrocyte suspension respectively. Cell biocompatibility: SD rat primary cardiomyocytes were inoculated on glass creeping tablets and polytetrafluoroethylene (PTFE) artificial vascular tablets for 3 days, then the lactate dehydrogenase (LDH) was released for 5 days and cell proliferation was detected. The results showed that PTFE prosthesis had no effect on the dynamic coagulation time and calcium recovery time of rabbit blood, and the hemolysis rate of PTFE artificial blood vessel was 2. 3%) compared with that of cardiomyocytes inoculated on ordinary glass creeping tablets. The results showed that the platelet aggregation of PTFE artificial blood vessel had no effect on the proliferation of cardiomyocytes and the release of lactate dehydrogenase (LDH). The results showed that PTFE artificial blood vessel had good blood compatibility and cytocompatibility.
【作者單位】： 鄭州大學第一附屬醫(yī)院心血管內科;
【基金】：河南省教育廳項目(142300410356)~~
【分類號】：R318.1

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