本文選題：磷銨兩性離子 + 聚氨酯��； 參考：《南京師范大學》2012年碩士論文

【摘要】：以2-甲基丙烯酰氧基乙基磷酰膽堿MPC為代表的磷銨兩性離子修飾材料表面,有較好的抗凝血性和血液相容性,本論文從簡單的原料三氯化磷和乙二醇出發(fā),經(jīng)過環(huán)構化、氧化、縮合、開環(huán)四步合成和MPC有類似結構的含碳碳雙鍵的磷銨兩性離子,這類反應的特點是,原料便宜易得,合成步驟簡單,實驗條件要求相對較低。并且通過紅外、核磁等測試手段對合成產(chǎn)物進行了檢測,圖譜證實合成產(chǎn)物與預期的結構一致。 聚氨酯是生物醫(yī)藥領域里常用的合成高分子材料,它廣泛應用于人造血管、導管以及各種診斷治療器械。但當聚氨酯材料與活體組織接觸時,會導致血栓形成以及炎癥等一些不良反應。這就對聚氨酯材料的生物相容性,尤其是血液相容性有一定的要求。而提高聚氨酯材料的血液相容性常用的方法有共混、表面涂層等物理方法,表面共價鍵合、接枝等化學方法。 本文采用合成的含碳碳雙鍵的磷銨兩性離子通過物理共混和化學接枝兩種方法對聚氨酯材料進行改性。并通過傅里葉變換紅外光譜(ATR-FTIR)、表面水接觸角(WCA)、熱重分析(TGA)和力學性能等物理手段來表征接枝膜的結構、穩(wěn)定性和親水性能。實驗結果也證明,兩種方法改性后的聚氨酯材料的親水性都有所提高。在此基礎上,也通過蛋白質吸附、體外血小板粘附和溶血實驗對材料的血液相容性進行了評價。結果也表明改性后聚氨酯材料的溶血率符合相關的國際標準,蛋白質吸附和血小板粘附都較少。
[Abstract]:The surface of amphoteric ammonium phosphate modified by 2-methacryloxy ethyl phosphatidylcholine (MPC) has good anticoagulant and blood compatibility. In this paper, phosphorus trichloride and ethylene glycol were used as raw materials, which were cyclized and oxidized. Condensation, ring-opening four-step synthesis of amphoteric ammonium phosphate with a similar structure to that of MPC with carbon-carbon double bonds is characterized by cheap raw materials, simple synthesis steps and relatively low experimental conditions. The synthesized products were detected by IR and NMR, and the structure of the synthesized products was confirmed to be in accordance with the expected structure. Polyurethane is a commonly used synthetic polymer material in the field of biomedicine. It is widely used in artificial blood vessels, catheters and various diagnostic and therapeutic instruments. However, some adverse reactions such as thrombosis and inflammation may occur when the polyurethane material is in contact with living tissue. This has certain requirements for the biocompatibility of polyurethane materials, especially for blood compatibility. The common methods to improve the blood compatibility of polyurethane are blending, surface coating, surface covalent bonding, grafting and other chemical methods. In this paper, the amphoteric ammonium phosphate containing carbon and carbon bonds was synthesized and modified by physical blending and chemical grafting. The structure, stability and hydrophilicity of the grafted films were characterized by Fourier transform infrared spectroscopy (FTIR), surface water contact angle (WCAA), thermogravimetric analysis (TGA) and mechanical properties. The experimental results also show that the hydrophilicity of the modified polyurethane is improved. On this basis, the blood compatibility of the materials was evaluated by protein adsorption, platelet adhesion and hemolysis in vitro. The results also showed that the hemolysis rate of the modified polyurethane was in accordance with the relevant international standards, and the protein adsorption and platelet adhesion were few.
【學位授予單位】：南京師范大學
【學位級別】：碩士
【學位授予年份】：2012
【分類號】：R318.08

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本文編號：1935830