本文選題：鈦酸鈣 + 羥基磷灰石��； 參考：《中南大學(xué)》2012年碩士論文

【摘要】：目的：本研究通過在體動(dòng)物實(shí)驗(yàn),研究鈦酸鈣“原位”涂層生物相容性,比較鈦酸鈣涂層、羥基磷灰石涂層及無涂層鈦材料的骨結(jié)合能力,探索鈦酸鈣涂層鈦材料作為新型體內(nèi)植入物的可行性。 方法：選取48只新西蘭大白兔,將鈦酸鈣涂層螺釘、羥基磷灰石螺釘及無涂層螺釘分別植入股骨內(nèi)髁、外髁,分別于2、4、8、12周進(jìn)行影像學(xué)檢測(cè)、組織學(xué)檢測(cè)和生物力學(xué)檢測(cè),觀察所研究材料在動(dòng)物體內(nèi)與骨組織結(jié)合情況,并進(jìn)行相關(guān)分析。 結(jié)果：(1)一般指標(biāo)：新西蘭兔飲食良好,2-3天后行動(dòng)良好,無跛行,傷口愈合均為甲級(jí),無明顯并發(fā)癥。(2)影像學(xué)檢測(cè)：X線照片顯示各時(shí)間點(diǎn)的螺釘與周圍骨組織無放射線透亮區(qū),植入的螺釘均留在原來的位置,無脫落,各股骨髁均沒有出現(xiàn)骨折。(3)組織學(xué)檢測(cè)：光學(xué)顯微鏡和掃描電鏡檢測(cè),鈦酸鈣涂層和羥基磷灰石涂層螺釘周圍骨組織排列均較致密,涂層與骨組織之間結(jié)合緊密,無纖維組織層,無涂層螺釘與骨組織之間存在纖維組織層。(4)生物力學(xué)測(cè)試：通過測(cè)得螺釘扭入、扭出時(shí)的扭力計(jì)算固定指數(shù),比較后發(fā)現(xiàn)鈦酸鈣涂層與骨結(jié)合強(qiáng)度明顯優(yōu)于無涂層的鈦表面,但弱于羥基磷灰石涂層。 結(jié)論：鈦酸鈣具有很好的組織相容性,與骨組織結(jié)合能力明顯優(yōu)于鈦,與羥基磷灰石涂層生物相容性類似。鈦酸鈣涂層與鈦基表面“原位”結(jié)合,不脫落,鈦酸鈣與骨組織可能存在化學(xué)鍵結(jié)合,是一種具有發(fā)展?jié)摿Φ墓强品N植體涂層材料。
[Abstract]:Objective: to study the biocompatibility of calcium titanate "in situ" coating and compare the bone binding ability of calcium titanate coating, hydroxyapatite coating and uncoated titanium material through in vivo animal experiments. To explore the feasibility of calcium titanate coated titanium as a new type of implant in vivo. Methods: calcium titanate coated screws, hydroxyapatite screws and uncoated screws were implanted into the medial and outer condyle of femur in 48 New Zealand white rabbits. The binding of the materials to bone tissue in vivo was observed and the correlation analysis was carried out. Results 1) General outcome measures: the New Zealand rabbits had good movement and no lameness after a good diet for 2-3 days. The wound healing was grade A, and there was no obvious complication. 2) the radiographic examination showed that the screws at each time point and the surrounding bone tissue had no radiography-transparent area. The implanted screws remained in their original position and did not fall off. No fracture was found in the condyle of the femur. Histological examination showed that the bone tissue around the screws was compact by optical microscope and scanning electron microscopy, and that around the calcium titanate and hydroxyapatite coated screws. The biomechanical test showed that there was a fibrous tissue layer between the coated screw and the bone tissue. The fixation index was calculated by measuring the torsion force of the screw in and out of the screw. It was found that the bonding strength of calcium titanate coating with bone was better than that of uncoated titanium surface, but weaker than that of hydroxyapatite coating. Conclusion: calcium titanate has good histocompatibility, and its binding ability to bone tissue is better than that of titanium, and the biocompatibility of calcium titanate is similar to that of hydroxyapatite coating. Calcium titanate coating is a kind of orthopedic implants coating material with potential development potential because it binds in situ with titanium substrate surface and does not fall off, and there may be chemical bond binding between calcium titanate coating and bone tissue.
【學(xué)位授予單位】：中南大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類號(hào)】：R318.08

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 賀定勇;孫旭峰;栗卓新;蔣建敏;王智慧;;等離子噴涂羥基磷灰石涂層結(jié)晶度的分析[J];北京工業(yè)大學(xué)學(xué)報(bào);2006年12期

2 賀定勇;趙秋穎;趙力東;孫旭峰;;噴涂工藝參數(shù)對(duì)HA涂層結(jié)構(gòu)和結(jié)晶度的影響[J];材料研究學(xué)報(bào);2007年06期

3 黃勇;龐小峰;何從軍;曹郁;楊野喬;;醫(yī)用鈦合金表面羥基磷灰石/二氧化鋯梯度復(fù)合涂層的制備[J];電鍍與涂飾;2011年01期

4 黃春鵬;王劍;車道闖;;引氟量對(duì)鈦表面電沉積含氟羥基磷灰石涂層的影響[J];電鍍與涂飾;2011年03期

5 熊睿;龐小峰;賈曉立;;鈦植入合金表面電化學(xué)沉積摻鎂羥基磷灰石涂層[J];電鍍與涂飾;2012年02期

6 李凱;周偉群;李軍;劉丹;李璇;;牙科用Ti-6Al-7Nb合金的體外細(xì)胞毒性研究[J];第四軍醫(yī)大學(xué)學(xué)報(bào);2007年10期

7 劉福,宋英,王福平,清水紀(jì)夫,五十嵐香,趙連城;Surface characteristics and structure of oxide films containing Ca and P on Ti substrate[J];Journal of Harbin Institute of Technology;2005年02期

8 趙秋穎;賀定勇;李曉延;栗卓新;;微束等離子噴涂制備羥基磷灰石涂層[J];焊接學(xué)報(bào);2008年03期

9 焦燕;呂宇鵬;肖桂勇;朱瑞富;許文花;;空心玻璃微球表面仿生沉積羥基磷灰石涂層[J];材料熱處理學(xué)報(bào);2011年S1期

10 閆娟娟;胡江;呂小衛(wèi);周健;高勃;;鈦表面激光快速成形CaTiO_3涂層成骨細(xì)胞相容性的研究[J];臨床口腔醫(yī)學(xué)雜志;2011年12期

，

本文編號(hào)：1916269