本文選題：細(xì)胞接觸成像技術(shù) + ELM算法　； 參考：《電子科技大學(xué)》2017年碩士論文

【摘要】：電子信息技術(shù)的發(fā)展越來越影響著對(duì)生物醫(yī)學(xué)信號(hào)的檢測(cè)、識(shí)別以及生物圖像信號(hào)的處理等方面。從光學(xué)顯微鏡到電子顯微鏡,從CT到MRI(核磁共振)可見一斑。隨著電子通信、信號(hào)處理、微芯片技術(shù)的飛速發(fā)展,以及生物醫(yī)學(xué)中所碰到的一些難題,如何將前者的算法、處理方法運(yùn)用到后者以解決實(shí)際中的問題成為本文研究?jī)?nèi)容。細(xì)胞分析儀是診斷常見疾病的一種重要儀器,其中對(duì)紅細(xì)胞、白細(xì)胞的分類計(jì)數(shù)是其一個(gè)關(guān)鍵性性能技術(shù)指標(biāo)。當(dāng)人體感染某些疾病時(shí),血液中不同種類的細(xì)胞的數(shù)量和細(xì)胞的形態(tài)會(huì)發(fā)生變化,醫(yī)護(hù)人員可以憑借細(xì)胞分析儀盡早發(fā)現(xiàn)并量化這些數(shù)量的變化和形態(tài)的改變,越早的發(fā)現(xiàn)越有利于治療。但目前商用細(xì)胞分析儀生產(chǎn)成本過高、設(shè)備儀器體積過大和細(xì)胞檢驗(yàn)步驟過于繁瑣等局限性都極大的限制了它的應(yīng)用。因此低價(jià)高效微型便攜的細(xì)胞分析儀逐漸成為火熱的研究方向。本文以細(xì)胞分析儀(細(xì)胞的檢測(cè)、分類識(shí)別、計(jì)數(shù))為主要研究對(duì)象,分別從細(xì)胞接觸成像、ELM算法、微流控技術(shù)、Coulter原理、磁珠實(shí)驗(yàn)等幾個(gè)方面來研究相關(guān)技術(shù),提出相應(yīng)的基于接觸成像的細(xì)胞分類計(jì)數(shù)方法和基于帶磁微珠的細(xì)胞分類計(jì)數(shù)方法,并與目前商用細(xì)胞分析儀進(jìn)行比較分析其性能,在達(dá)到臨床診斷要求的精度的情況下可以極大的降低設(shè)備成本、簡(jiǎn)化細(xì)胞檢測(cè)工序。本文的研究成果對(duì)于簡(jiǎn)單便攜式低成本的細(xì)胞分析儀的設(shè)計(jì)具有極大的參考價(jià)值。同時(shí)本文的研究方法可以應(yīng)用在更廣泛的領(lǐng)域,例如可用于對(duì)類細(xì)胞物體的識(shí)別計(jì)數(shù)和對(duì)經(jīng)過特殊處理后的粒子的檢測(cè)(環(huán)境保護(hù)方面)等。
[Abstract]:The development of electronic information technology has more and more influence on the detection, recognition and processing of biomedical signals. From optical microscope to electron microscope, from CT to MRI (nuclear magnetic resonance) can be seen. With the rapid development of electronic communication, signal processing, microchip technology and some difficult problems encountered in biomedicine, how to apply the former algorithm and processing method to solve the practical problems becomes the research content of this paper. Cell analyzer is an important instrument for the diagnosis of common diseases, in which the classification of red blood cells and white blood cells is a key performance index. When the human body is infected with certain diseases, the number and shape of different types of cells in the blood will change, and doctors and nurses can use the cell analyzer to detect and quantify these changes as soon as possible. The earlier the discovery, the better the treatment. But at present, the cost of commercial cell analyzer is too high, the volume of equipment and instrument is too large and the steps of cell test are too complicated, which greatly limit its application. Therefore, low-cost and high-efficient micro-portable cell analyzer has gradually become a hot research direction. In this paper, the cell analyzer (cell detection, classification recognition, counting) as the main research object, respectively from the cell contact imaging algorithm, microfluidic control technology Coulter principle, magnetic bead experiment and other aspects to study the relevant technology. The corresponding cell classification counting method based on contact imaging and the cell classification counting method based on magnetic microbeads are proposed and compared with the current commercial cell analyzer. The accuracy of clinical diagnosis can greatly reduce the cost of equipment and simplify the process of cell detection. The research results in this paper have great reference value for the design of simple portable and low-cost cell analyzer. At the same time, this research method can be used in a wide range of fields, such as the recognition of cell-like objects and the detection of particles after special treatment (environmental protection) and so on.
【學(xué)位授予單位】：電子科技大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R197.39

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 李作仁;王佳玉;安雨桐;祁欣;;極限學(xué)習(xí)機(jī)在圖像分割中的應(yīng)用[J];電腦知識(shí)與技術(shù);2016年03期

2 許立萍;;血涂片分析在血常墢檢驗(yàn)中的重要性及臨床分析[J];大家健康(學(xué)術(shù)版);2014年13期

3 孫榮斌;吳家兵;丁麗花;;職業(yè)健康檢查中三分群與五分類血液分析儀檢測(cè)結(jié)果比較[J];中國(guó)工業(yè)醫(yī)學(xué)雜志;2014年03期

4 吳學(xué)忠;呂蓉;紀(jì)慶麟;吳君勝;魏家余;周學(xué)勇;;不同滲透壓NaCl溶液對(duì)紅細(xì)胞的影響[J];臨床輸血與檢驗(yàn);2014年01期

5 李全煥;涂學(xué)亮;劉紅麗;朱沖;黃偉雄;;貝克曼庫爾特HMX五分類血細(xì)胞分析儀的臨床應(yīng)用[J];檢驗(yàn)醫(yī)學(xué)與臨床;2008年10期

6 王松霞;韋涌濤;劉程;李武倫;;BC-5500型全自動(dòng)血液分析儀使用與評(píng)價(jià)[J];醫(yī)學(xué)檢驗(yàn)與臨床;2008年02期

7 王青云;;細(xì)胞與疾病的關(guān)系[J];中國(guó)社區(qū)醫(yī)師(綜合版);2007年02期

8 陳林,張莉滟,丁海明,莊俊華;ADVIA120血液分析儀過氧化物酶鞘液試劑的研制與應(yīng)用[J];臨床檢驗(yàn)雜志;2005年05期

9 徐健君,翟海云,陳纘光,譚學(xué)才,蔡沛祥,莫金垣;毛細(xì)管電泳高頻電導(dǎo)法同時(shí)測(cè)定阿莫西林和克拉維酸鉀含量[J];應(yīng)用化學(xué);2005年06期

10 謝翔,張春,王志華;微電子技術(shù)在生物醫(yī)學(xué)中的應(yīng)用與發(fā)展[J];電路與系統(tǒng)學(xué)報(bào);2003年02期

相關(guān)會(huì)議論文 前1條

1 徐征;張媛;劉沖;陳剛;;微流控芯片中鞘流控制技術(shù)研究[A];慶祝中國(guó)力學(xué)學(xué)會(huì)成立50周年暨中國(guó)力學(xué)學(xué)會(huì)學(xué)術(shù)大會(huì)’2007論文摘要集（下）[C];2007年

，

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