本文選題：生物醫(yī)用鈦 + 表面改性��； 參考：《湖北大學(xué)》2014年碩士論文

【摘要】：生物醫(yī)用鈦金屬材料由于其良好的力學(xué)性能、易加工性、與人骨相近的彈性模量、耐腐蝕性和良好的生物相容性被廣泛應(yīng)用于人工骨關(guān)節(jié)、骨釘、牙種植體等硬組織材料。但是,鈦及鈦合金存在生物惰性的缺點,植入人體后與周圍組織不能達(dá)到骨性結(jié)合,只是簡單的機(jī)械鎖合,易被纖維組織包裹與宿主組織隔離,長此以往會引起血栓而導(dǎo)致植入失敗。另外,在臨床手術(shù)中,細(xì)菌感染是很常見的一大問題,全面的消毒和無菌操作仍然避免不了術(shù)后感染的發(fā)生。臨床上主要解決途徑是注射抗生素,但抗生素注射具有特異性,需長期注射且會產(chǎn)生抗藥菌株。 基于以上問題,本論文提出在鈦金屬表面構(gòu)建功能化的納米結(jié)構(gòu),運用水熱處理法在鈦片表面原位生長出一維納米相結(jié)構(gòu),提高材料生物相容性,增加材料的粗糙度和比表面積,為后續(xù)摻雜銀納米粒子提供附著位點；通過體外仿生礦化在材料表面沉積羥基磷灰石涂層增強(qiáng)材料生物活性；在鈦酸鹽納米結(jié)構(gòu)上載入Ag納米顆粒制備出兼具生物相容性和抑菌性能的多功能復(fù)合型植入材料。具體包括如下工作： 1.鈦金屬表面一維納米結(jié)構(gòu)的制備、影響因素及生長機(jī)理的研究 2.在含鈦酸鹽納米結(jié)構(gòu)的鈦表面摻雜銀離子提高材料抗菌性能 3.一維納米相修飾后的樣品表面生物礦化及表面特征 4.水熱處理后的樣品及摻銀樣品的體外細(xì)胞實驗 研究結(jié)果表明：通過水熱法可以在鈦基表面制備出形貌均一,涂層均勻的鈦酸鹽一維納米結(jié)構(gòu)薄膜,反應(yīng)溫度和堿液濃度均對材料表面微觀形貌有影響；最佳水熱工藝條件為純鈦片與0.2M NaOH在180°C下反應(yīng)72小時得到納米針狀改性表面；通過紫外光化學(xué)法可以在材料表面載銀,銀納米顆粒在鈦基表面分布均勻,隨著硝酸銀溶液濃度的增加,抗菌效果更好；水熱處理后的材料表面能夠引導(dǎo)羥基磷灰石在表面沉積,并且能夠有效提高早期細(xì)胞在材料表面的增殖與分化。
[Abstract]:Biomedical titanium metal materials are widely used in artificial bone joints, bone nails, dental implants and other hard tissue materials due to their good mechanical properties, easy processing, similar to human bone elastic modulus, corrosion resistance and good biocompatibility. However, titanium and titanium alloys have the disadvantage of biological inert, after implanted into the human body and the surrounding tissues can not achieve osseous binding, but simply mechanical locking, easy to be wrapped in fibrous tissue and isolated from the host tissue. In the long run, it can cause thrombus and lead to the failure of implantation. In addition, bacterial infection is a common problem in clinical surgery. In clinic, the main solution is to inject antibiotics, but antibiotic injection is specific, need long-term injection and will produce drug-resistant strains. Based on the above problems, this paper proposes to construct functional nanostructures on the surface of titanium, and to improve the biocompatibility of the materials by in situ growth of one-dimensional nanostructures on the surface of titanium by hydrothermal treatment. Increase the roughness and specific surface area of the material, provide the attachment site for the subsequent doped silver nanoparticles, and enhance the bioactivity of the material by biomimetic mineralization deposition of hydroxyapatite coating on the material surface in vitro. A multifunctional composite implant material with biocompatibility and bacteriostasis was prepared by loading Ag nanoparticles on titanate nanostructures. These include the following: 1. Preparation, influencing factors and growth Mechanism of One-Dimensional Nanostructures on Titanium Surface 2. Doping Silver Ion on Titanium Surface containing Titanate Nanostructures to improve Antibacterial Properties 3. Surface biomineralization and surface characteristics of one-dimensional nano-phase modified samples 4. In Vitro Cell experiment of samples after hydrothermal treatment and Silver doped samples The results show that the surface morphology of titanium substrate can be uniform by hydrothermal method, and the one-dimensional nanostructured titanate thin films with uniform coating can be prepared. The reaction temperature and the concentration of alkali have an effect on the surface morphology of the materials. The optimum hydrothermal conditions were as follows: the pure titanium sheet reacted with 0.2 M NaOH at 180 擄C for 72 hours to obtain the needle modified surface, and the silver nanoparticles could be loaded on the surface of the material by ultraviolet photochemistry, and the silver nanoparticles distributed uniformly on the surface of titanium substrate. With the increase of the concentration of silver nitrate solution, the antibacterial effect is better, and the surface of the material after hydrothermal treatment can lead to hydroxyapatite deposition on the surface, and can effectively improve the proliferation and differentiation of early cells on the surface of the material.
【學(xué)位授予單位】：湖北大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：TG178;R318.08

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