本文選題：骨科植入材料 + 聚醚醚酮�。� 參考：《基因組學與應用生物學》2017年09期

【摘要】：本研究基于聚醚醚酮的骨科植入材料生物相容性的研究,進一步分析聚醚醚酮(polyether-ether-ketone,PEEK)骨科植入材料生物的相容性能,以有效提高其生物功能性,進而獲得更加可靠的骨-植入體界面。本研究通過以新西蘭大白兔為研究對象,采用改性/未改性的PEEK材料制備了腰椎模型并植入,最后進行了生物力學與Micro CT分析。實驗研究表明,以改性及未改性的PEEK材料制備的腰椎假體在植入動物體內(nèi)后后,動物體內(nèi)未發(fā)生顯著相關的急慢性毒性反應。對比植入的兩種PEEK假體我們發(fā)現(xiàn),改性的PEEK腰椎假體在植入動物后第4周,其臨近椎骨的植入部位在骨體積分數(shù)等參數(shù)上發(fā)生了明顯的改善(p0.05);植入后第8周檢查,以骨體積分數(shù)(BV/TV)、(骨密度(BMD)、骨小梁厚度(Tb.Th)、骨小梁分離度(Tb.Sp)以及骨表面體積分數(shù)(BS/BV)等為代表的多項重要的骨組織形態(tài)計量學參數(shù)均發(fā)生了顯著的改善(p0.05)。同時,研究通過采用拔出試驗來驗證植入材料的生物力學性能,實驗發(fā)現(xiàn)改性PEEK材料能夠有效促進植入假體與椎骨的緊密結(jié)合。因此,實驗中針對PEEK材料采用rh BMP-2與膠原蛋白對表面進行改性可以高效地、快速地達到效果,并且能夠明顯提高骨科植入的PEEK材料的生物功能性與生物相容性。
[Abstract]:In this study, the biocompatibility of polyether ether ketone (PEEK) orthopedic implants was studied, and the biocompatibility of polyether ether ketones (PEEK) implants was analyzed.Thus, a more reliable bone-implant interface is obtained.In this study, the lumbar vertebrae model was prepared and implanted with modified / unmodified PEEK material in New Zealand white rabbits. Finally, biomechanics and Micro CT analysis were carried out.The experimental results showed that there was no significant acute or chronic toxic reaction in the lumbar vertebrae prosthesis made of modified or unmodified PEEK material after implanted into the animal body.Comparing the two kinds of PEEK prosthesis, we found that the modified PEEK lumbar vertebra prosthesis had a significant improvement in bone volume fraction and other parameters at the fourth week after implantation, and was examined at the 8th week after implantation.Several important bone histomorphometry parameters, such as bone volume fraction (BV / V) (bone density (BMD), trabecular thickness, trabecular separation, bone trabecular separation, and bone surface volume fraction (BS / BV)), have been significantly improved (p0.05).At the same time, the biomechanical properties of the implants were verified by pull-out test. It was found that the modified PEEK materials could effectively promote the close combination of the implants and the vertebrae.Therefore, using rh BMP-2 and collagen to modify the surface of PEEK materials in the experiment can achieve the effect efficiently and quickly, and can obviously improve the biofunctional and biocompatibility of PEEK materials implanted in orthopedic department.
【作者單位】： 新疆醫(yī)科大學附屬中醫(yī)醫(yī)院骨一科;
【基金】：新疆醫(yī)科大學附屬中醫(yī)醫(yī)院資助
【分類號】：R318.08;R68

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