本文選題：鈷鉻合金　切入點(diǎn)：離子析出　出處：《中南大學(xué)》2012年碩士論文

【摘要】：目的鈷鉻合金(Co-Cr alloy)因其優(yōu)良的機(jī)械性能、良好的生物相容性、價(jià)格合理一直是重要的口腔修復(fù)材料,廣泛應(yīng)用于口腔臨床修復(fù)。鈷鉻合金鑄造支架可摘局部義齒及全冠戴入口腔后,釋放出鈷、鉻等重金屬離子能被機(jī)體吸收,形成對(duì)局部和全身組織的影響。近來(lái),人們?nèi)找骊P(guān)注鈷鉻合金臨床應(yīng)用的安全性問(wèn)題。鉆鉻合金應(yīng)用于口腔臨床修復(fù)時(shí),釋放出的鉻離子的量的多少及其影響因素是首要解決的問(wèn)題。 鈷鉻合金在口腔修復(fù)應(yīng)用時(shí)會(huì)受到多種口腔內(nèi)環(huán)境復(fù)雜因素的影響,導(dǎo)致鉻離子釋放特性的變化。本文依據(jù)口腔修復(fù)體形態(tài)的相應(yīng)條件設(shè)計(jì)鈷鉻合金試件的大小。通過(guò)體外模擬口腔內(nèi)pH值、溫度及時(shí)間的變化來(lái)研究這三種因素對(duì)應(yīng)用于口腔的鈷鉻合金中鈷、鉻離子釋放特性的影響。為選擇具有良好的耐腐蝕性能的牙科合金材料,以及后續(xù)試驗(yàn)中析出的鈷、鉻離子的性質(zhì)對(duì)人體的影響提供實(shí)驗(yàn)依據(jù)。 方法采用臨床口腔修復(fù)常用的鈷鉻合金試件,稱量后將試件放入棕色帶蓋的容量瓶中,每瓶一件,分別加入PH值為5.0、7.0、9.0的人工唾液和PH值為7.0的純水(100m1)。人工唾液組放入8℃、37℃和45℃恒溫孵育箱中,每組3瓶；純水組放入37℃恒溫孵育箱中。分別進(jìn)行靜態(tài)浸泡2周、4周、6周、8周。進(jìn)行各種設(shè)定條件下的鉻、鈷離子析出實(shí)驗(yàn)。采用電感耦合等離子質(zhì)譜法(ICP-MS)檢測(cè)各瓶溶液中析出的鉻、鈷離子濃度,數(shù)據(jù)進(jìn)行統(tǒng)計(jì)分析。 結(jié)果 1.pH=7.0,溫度為37℃時(shí),鈷鉻合金分別浸泡于人工唾液和純水中,鈷、鉻離子的析出濃度在人工唾液中均高于純水,差異有統(tǒng)計(jì)學(xué)意義(p0.05),在不同時(shí)間點(diǎn)上鈷、鉻離子的析出量不同,差異有統(tǒng)計(jì)學(xué)意義(p0.05),且浸泡液和時(shí)間對(duì)鈷、鉻離子的析出均有交互作用(p0.05). 2.溫度為37。C時(shí),pH=5.0時(shí),鈷鉻合金中析出的鉻離子量隨時(shí)間逐漸增加,鈷離子從第2周析出速度達(dá)高峰。對(duì)不同pH值組進(jìn)行兩兩比較,pH=7.0組和pH=9.0組差異沒(méi)有統(tǒng)計(jì)學(xué)意義(p0.05),其他任意兩組差異有統(tǒng)計(jì)學(xué)意義(p0.05)。 3.pH=7.0時(shí),不同溫度條件下,鉻、鈷離子的析出量不同,且溫度與時(shí)間對(duì)鈷、鉻離子的析出有交互作用。溫度為45℃、處理時(shí)間為8周時(shí)鉻離子的析出速度最快。 4.時(shí)間為第4周時(shí),不同pH值組之間,鈷、鉻離子的析出濃度均有差異(p0.05),任意兩組之間差異有統(tǒng)計(jì)學(xué)意義,不同溫度之間鉆、鉻離子的析出也均有差異,溫度(T)=45。C組T=8℃組T=37℃組,且任意兩組之間差異有統(tǒng)計(jì)學(xué)意義(p0.05),pH值和溫度有交互作用。 5.溫度為37℃時(shí),不同時(shí)間點(diǎn),失重的質(zhì)量不同,隨著時(shí)間的延長(zhǎng),失重質(zhì)量增多,不同pH組之間失重的質(zhì)量不同,差異有統(tǒng)計(jì)學(xué)意義(p0.05)。pH值和時(shí)間對(duì)鈷鉻合金的失重質(zhì)量不存在交互作用(p0.05)。不同pH值組失重的線性變化趨勢(shì)明顯不同(p=0.000)。 結(jié)論 (1)鈷、鉻離子的析出濃度在人工唾液中均高于純水。 (2)pH值、溫度和時(shí)間對(duì)鉆鉻合金試件在人工唾液中金屬離子的析出有影響,即鈷鉻合金試件在偏酸或偏堿、低溫或高溫條件下分別比pH值為7.0、溫度為37℃時(shí)的鉻、鈷離子析出量要多,并隨時(shí)間的延長(zhǎng)而增加。pH值與時(shí)間、溫度和時(shí)間之間有交互作用。
[Abstract]:The purpose of the cobalt chromium alloy (Co-Cr alloy) because of its excellent mechanical properties, good biocompatibility, reasonable price has been oral repair material, widely used in prosthodontics. Cobalt chromium alloy casting framework of removable partial denture and complete crown in oral cavity, the release of cobalt, chromium and other heavy metal ions be absorbed by the body, the formation of local and systemic impact on the organization. Recently, people pay more attention to the safety problems of clinical application of cobalt chromium alloy. Cobalt chromium alloy used in prosthodontics, chromium ion release quantity and its influencing factors is the primary problem.
The cobalt chromium alloy will be a variety of oral environment of complicated factors in the application of Prosthodontics, lead to changes in release characteristics of chromium ions. The corresponding design conditions of cobalt chromium alloy based on dental morphology of the specimen size. Through in vitro simulation of oral pH values, changes in temperature and time to study the three factors for the cobalt chromium alloy in oral cobalt, chromium ions influence the release characteristics of dental alloys. With good corrosion resistance for the selection, and the precipitation of cobalt in subsequent experiments, provide experimental basis for the effect of properties of chromium ions on the human body.
Methods clinical dental cobalt chromium alloy commonly used test pieces, after weighing the specimen into the brown covered bottle, a bottle of 5.0,7.0,9.0, were added to the pH value of artificial saliva and pH of 7 water (100m1). The artificial saliva group into 8 degrees, 37 degrees and 45 degrees constant temperature incubation in each box, 3 bottles of water in a constant temperature of 37 DEG C; group incubator. Were static immersion for 2 weeks, 4 weeks, 6 weeks, 8 weeks. All conditions of chromium, cobalt ion precipitation experiments. Using inductively coupled plasma mass spectrometry (ICP-MS) detection of each bottle of chromium in solution precipitation the cobalt ion concentration, and statistical data analysis.
Result
1.pH=7.0, the temperature is 37 degrees centigrade, cobalt chromium alloys were immersed in artificial saliva and pure water, precipitation of cobalt, chromium ions concentration were higher than that of pure water in artificial saliva, the difference was statistically significant (P0.05), at different time points on the precipitation of cobalt, chromium ions are different, the difference was statistically significant (P0.05), and soak time on the precipitation of cobalt and chromium ions, the interaction of the (P0.05).
2. when the temperature is 37.C pH=5.0, the amount of chromium ions in precipitation of cobalt chromium alloy increased gradually with time, cobalt ions from the second week precipitation rate reached the peak. The different values of the pH group was 22, the difference between pH=7.0 group and pH=9.0 group had no statistical significance (P0.05), any other two groups the difference was statistically significant (P0.05).
At 3.pH=7.0, the precipitation of Cr and Co ions is different at different temperatures, and the interaction between temperature and time on the precipitation of cobalt and chromium ions is the fastest. When the temperature is 45 C and the treatment time is 8 weeks, the precipitation of Cr ions is the fastest.
The 4. time is fourth weeks, different pH values between the groups, cobalt, chromium ion concentration precipitation difference (P0.05), there was statistical significance of any differences between the two groups, the different temperature between the drill, the precipitation of chromium ions also have differences in temperature (T) of =45.C group T=8 group T=37 group C C, there was statistical significance and any differences between the two groups (P0.05), pH value and temperature interaction.
5. temperature is 37 degrees centigrade at different time points, the loss of quality is different, with the extension of time, the quality of weight loss increased, between different pH group loss of quality is different, the difference was statistically significant (P0.05).PH value and time of CO Cr alloy weight quality there is no interaction (P0.05) with different pH values. The linear trend of weightlessness is significantly different (p=0.000).
conclusion
(1) the concentration of cobalt and chromium ions is higher in artificial saliva than in pure water.
(2) the pH value of CO Cr alloy specimens in artificial saliva precipitation of metal ions have the effect of temperature and time, the co Cr alloy specimens under partial acid or alkali, low temperature or high temperature conditions were higher than the pH value is 7, the temperature is 37 DEG C when the chromium, cobalt ion precipitation to, and the extension of time and increase the.PH value and the time, there was an interaction between temperature and time.

【學(xué)位授予單位】：中南大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類號(hào)】：R783.1

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