本文選題：近紅外漫射光成像　切入點(diǎn)：頻域外差　出處：《天津大學(xué)》2012年碩士論文

【摘要】：內(nèi)窺式近紅外漫射光成像技術(shù)是一種可用于內(nèi)部器官癌癥檢測的新型光學(xué)測量技術(shù)，因其具有實(shí)時(shí)、無創(chuàng)的特點(diǎn)在癌癥的早期診斷方面發(fā)揮著重要作用。為了有效的實(shí)現(xiàn)對早期宮頸癌的檢測，本文在原有頻域系統(tǒng)的基礎(chǔ)上，建立了基于有效探測區(qū)理論（Effective Detection Range，EDR）的內(nèi)窺式圓周掃描成像系統(tǒng)。 首先，為了實(shí)現(xiàn)基于EDR的內(nèi)窺檢測，設(shè)計(jì)了一種新型的內(nèi)窺式旋轉(zhuǎn)探頭，僅用一根源光纖和一根探測光纖即可實(shí)現(xiàn)圓周掃描成像，簡化了系統(tǒng)并降低成本。并利用蒙特卡洛模擬對光纖參數(shù)的選擇提供理論指導(dǎo)。為了實(shí)現(xiàn)光垂直照射到宮頸內(nèi)壁并垂直接收，探頭的源光纖頂端加上一端切成45°斜面的自聚焦透鏡，對光實(shí)現(xiàn)準(zhǔn)直和偏折90°的作用，探測光纖直接將光纖頂端切成45°斜面，用于接收垂直于組織體壁的光。內(nèi)窺探頭的旋轉(zhuǎn)精度的實(shí)驗(yàn)結(jié)果表明：源光纖對于幅值和相位的測量的最大相對誤差分別是1.7%和0.13%，探測光纖的最大相對誤差分別是3.01%和0.58%。 其次，為了實(shí)現(xiàn)頻域系統(tǒng)的自動(dòng)化控制，本文在LabVIEW平臺下，將內(nèi)窺旋轉(zhuǎn)探頭和頻域系統(tǒng)結(jié)合進(jìn)行軟件集成，，從而節(jié)省人力和時(shí)間。并在不同的源探距離下驗(yàn)證了基于內(nèi)窺探頭頻域系統(tǒng)的精度，實(shí)驗(yàn)結(jié)果表明，該系統(tǒng)測量幅值和相位相對誤差分別為12.3%和20.9%，另外，針對上述結(jié)果，本文對系統(tǒng)可能存在的誤差原因及改進(jìn)措施進(jìn)行了分析和闡述。 最后，在上述內(nèi)窺式頻域系統(tǒng)的基礎(chǔ)上，本文分別利用固體仿體和仿宮頸組織對系統(tǒng)的成像能力進(jìn)行了驗(yàn)證。在固體仿體實(shí)驗(yàn)中，分別對單目標(biāo)仿體和雙目標(biāo)仿體的異質(zhì)體進(jìn)行了重構(gòu)實(shí)驗(yàn)，結(jié)果表明：重構(gòu)的目標(biāo)體的位置和大小和實(shí)際的目標(biāo)體基本一致，雙異質(zhì)體可被清晰分開，吸收和約化散射系數(shù)的量化度（Quantitative Ratio，QR）分別可達(dá)到25%和20%以上。仿宮頸組織的實(shí)驗(yàn)結(jié)果表明：重構(gòu)異質(zhì)體的位置正確，且重構(gòu)出的吸收系數(shù)和約化散射系數(shù)的QR值分別可達(dá)到25.3%和18.7%。綜上所述，基于EDR的內(nèi)窺式圓周掃描成像系統(tǒng)可獲得合理的成像質(zhì)量，為臨床實(shí)驗(yàn)的實(shí)施打下了堅(jiān)實(shí)基礎(chǔ)。
[Abstract]:Endoscopic near-infrared diffuse light imaging (NIR) is a new optical measurement technique that can be used to detect cancer in internal organs because of its real time. Non-invasive features play an important role in the early diagnosis of cancer. In order to effectively detect early cervical cancer, this paper is based on the original frequency domain system. An endoscopic circumferential scanning imaging system based on effective Detection (EDR) is established. First of all, in order to realize endoscope detection based on EDR, a new type of endoscope rotary probe is designed, which can realize circumferential scanning imaging with only one source fiber and one detecting fiber. It simplifies the system and reduces the cost. Monte Carlo simulation is used to provide theoretical guidance on the choice of optical fiber parameters. In order to achieve vertical light exposure to the inner wall of the cervix and vertical reception, The probe has a self-focusing lens cut into 45 擄sloping plane at one end of the source optical fiber, which can collimate and deflect the light by 90 擄. The probe fiber directly cuts the top of the fiber into 45 擄oblique plane. The experimental results show that the maximum relative errors for the measurement of amplitude and phase of the source fiber are 1.7% and 0.13%, respectively, and the maximum relative errors for the probe are 3.01% and 0.58 respectively. Secondly, in order to realize the automatic control of the frequency domain system, this paper integrates the endoscope rotation probe and the frequency domain system under the LabVIEW platform to carry on the software integration. The precision of frequency domain system based on endoscope probe is verified under different source range. The experimental results show that the relative errors of amplitude and phase of the system are 12.3% and 20.9%, respectively. In addition, in view of the above results, In this paper, the possible error causes and improvement measures of the system are analyzed and expounded. Finally, on the basis of the frequency domain system of endoscope, the imaging ability of the system is verified by solid imitating body and cervical tissue, respectively. Experiments were carried out on the homogeneity of single target and double target respectively. The results show that the position and size of the reconstructed object are basically the same as the actual object, and the double heterogeneity can be clearly separated. The quantification of absorption and reductive scattering coefficients can reach more than 25% and 20% respectively. The QR values of the reconstructed absorption coefficient and reduced scattering coefficient can reach 25.3% and 18.7% respectively. In conclusion, the endoscopic circumferential scanning imaging system based on EDR can obtain reasonable imaging quality and lay a solid foundation for clinical experiment.
【學(xué)位授予單位】：天津大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R310

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