本文選題：納米銀　切入點(diǎn)：海藻酸凝膠　出處：《太原理工大學(xué)》2014年碩士論文

【摘要】：納米銀抗菌凝膠是由納米銀和高分子材料構(gòu)成的復(fù)合物。近些年來,納米銀抗菌凝膠作為一種有效的抗菌材料被廣泛地應(yīng)用于臨床。最近的研究結(jié)果顯示,過量的納米銀容易導(dǎo)致細(xì)胞毒性。因此,如何有效地控制復(fù)合物中納米銀的釋放水平,以期實(shí)現(xiàn)抗菌效果,并避免細(xì)胞毒性,成為當(dāng)前納米銀抗菌凝膠所要解決的一個(gè)關(guān)鍵問題。 本研究采用海藻酸鈉作為載體,通過原位還原反應(yīng)、凝膠化、梯度脫水、真空干燥等過程,形成海藻酸凝膠-納米銀復(fù)合物(Alg-AgNPs),海藻酸的作用有二。一是作為合成并固定納米銀顆粒的載體,從而避免了納米銀顆粒聚集而失去其納米效應(yīng)。二是海藻酸凝膠作為環(huán)境敏感性材料,實(shí)現(xiàn)納米銀的控制釋放。復(fù)合物的殺菌性能及細(xì)胞毒性決定于納米銀顆粒的尺寸及濃度,結(jié)果顯示,在該體系中納米銀顆粒的平均尺寸為2-6m,均勻地分散在凝膠中,當(dāng)該復(fù)合物與模擬體液接觸后,體液中的Na+與復(fù)合物中的Ca2+發(fā)生離子交換,釋放出納米銀顆粒,納米銀顆粒的釋放水平取決于復(fù)合物中AgNPs的裝載量及體液的量。當(dāng)介質(zhì)中該納米銀顆粒的濃度達(dá)到1.1ppm時(shí),能實(shí)現(xiàn)有效的殺菌性能(4小時(shí)內(nèi)殺滅107大腸桿菌和金黃色葡萄球菌),并且殺菌效率與納米銀顆粒的濃度呈正相關(guān)。而隨著納米顆粒濃度的增大,逐步會(huì)導(dǎo)致細(xì)胞壞死。因此,控制納米銀顆粒濃度不高于1.1ppm可實(shí)現(xiàn)抗菌并避免細(xì)胞毒性。該復(fù)合物通過離子交換響應(yīng)實(shí)現(xiàn)對(duì)納米銀顆粒釋放的智能控釋,實(shí)現(xiàn)了抗菌性能,并避免了細(xì)胞毒性,為納米銀抗菌材料的研究提供了一個(gè)新思路。
[Abstract]:Nano-silver antibacterial gel is a complex composed of nano-silver and polymer materials. In recent years, nano-silver antibacterial gel has been widely used in clinic as an effective antibacterial material. Excessive amounts of silver nanoparticles can easily lead to cytotoxicity. Therefore, how to effectively control the release level of silver nanoparticles in the complex in order to achieve antibacterial effect and avoid cytotoxicity, It has become a key problem to be solved by nano-silver antimicrobial gel. In this study, sodium alginate was used as carrier, through in situ reduction reaction, gelation, gradient dehydration, vacuum drying and so on. To form alginate gel-nano-silver complex Alg-AgNPsN, alginic acid acts as a carrier for the synthesis and immobilization of silver nanoparticles. Therefore, the aggregation of silver nanoparticles and the loss of their nanometer effects are avoided. Second, alginate gel is used as an environmentally sensitive material to realize the controlled release of silver nanoparticles. The bactericidal properties and cytotoxicity of the complexes are determined by the size and concentration of silver nanoparticles. The results showed that the average size of silver nanoparticles in the system was 2-6 m, which was uniformly dispersed in the gel. After contact with the simulated body fluid, the Na in the body fluid and the Ca2 in the complex produced ion exchange, resulting in the release of silver nanoparticles. The release level of silver nanoparticles depends on the amount of AgNPs in the composite and the amount of body fluid. When the concentration of the nanoparticles in the medium reaches 1.1ppm, It can achieve effective bactericidal performance and kill 107 Escherichia coli and Staphylococcus aureus within 4 hours, and the bactericidal efficiency is positively correlated with the concentration of silver nanoparticles. Controlling the concentration of silver nanoparticles below the concentration of 1.1ppm can achieve antimicrobial activity and avoid cytotoxicity. The complex can realize intelligent controlled release of silver nanoparticles by ion exchange response, achieve antibacterial properties, and avoid cytotoxicity. It provides a new idea for the research of nano-silver antibacterial materials.
【學(xué)位授予單位】：太原理工大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R318.08

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