本文選題：細(xì)菌感染　切入點(diǎn)：檢測(cè)　出處：《微生物學(xué)通報(bào)》2014年05期 　論文類型：期刊論文

【摘要】：細(xì)菌感染顯像劑是利用一些示蹤基團(tuán)(如放射性核素及熒光染料)標(biāo)記對(duì)細(xì)菌具有特異性識(shí)別作用的導(dǎo)向物,通過檢測(cè)示蹤信號(hào)定位細(xì)菌感染部位。到目前為止,針對(duì)細(xì)菌內(nèi)的特異性位點(diǎn)(如細(xì)胞壁、酶、受體等)研制和開發(fā)了一系列細(xì)菌感染顯像劑(包括核素標(biāo)記的抗生素、噬菌體、抗菌肽、核苷及熒光染料標(biāo)記的糖類等),這些顯像劑能在細(xì)菌感染部位高度特異性聚集,有望應(yīng)用于臨床早期診斷細(xì)菌感染。本文對(duì)這些細(xì)菌感染顯像劑的種類、濃集機(jī)制及研究現(xiàn)狀進(jìn)行了概述,并在此基礎(chǔ)上,總結(jié)了理想細(xì)菌感染顯像劑所應(yīng)具有的特征,為進(jìn)一步研究和開發(fā)新的細(xì)菌感染顯像劑提供參考。
[Abstract]:Bacterial infection imaging agents are targets that use tracer groups, such as radionuclides and fluorescent dyes, to specifically recognize bacteria and locate bacterial infection sites by detecting tracer signals. A series of bacterial infection imaging agents (including radionuclide labeled antibiotics, bacteriophages, antimicrobial peptides, etc.) have been developed for specific sites in bacteria (such as cell walls, enzymes, receptors, etc.). Nucleoside and fluorescein dye labeled carbohydrates, these imaging agents are highly specific to the bacterial infection sites and are expected to be used in the early clinical diagnosis of bacterial infections. The mechanism of concentration and the present research situation were summarized. On the basis of this, the characteristics of ideal bacteriological infection imaging agent were summarized, which provided a reference for further research and development of new bacterial infection imaging agent.
【作者單位】： 中國(guó)藥科大學(xué)生命科學(xué)與技術(shù)學(xué)院;
【分類號(hào)】：R817

【參考文獻(xiàn)】

相關(guān)期刊論文 前3條

1 付占立;;炎癥顯像劑的臨床應(yīng)用及研究進(jìn)展[J];同位素;2010年03期

2 錢慧敏;陳海燕;王e，

本文編號(hào)：1616038