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  本文選題：聚對苯二甲酸乙二醇酯　切入點：空穿編織　出處：《第四軍醫(yī)大學》2012年碩士論文　論文類型：學位論文

【摘要】：背景：隨著國力的發(fā)展壯大以及生活水平的提高，體育運動逐漸普及，而關節(jié)韌帶的損傷發(fā)生率也逐年增高，保守估計每年韌帶損傷的患者應不下1千萬例。人體的韌帶組織與骨組織不同，發(fā)生損傷斷裂后定然無法自然愈合而必須進行早期修復，，這種損傷若不加處理通常會降低關節(jié)穩(wěn)定性和繼發(fā)其他組織結構損傷，并最終導致嚴重的相關關節(jié)運動功能障礙。已發(fā)明并投入使用的韌帶重建方法有很多，得到廣泛共識的是自體或異體肌腱移植重建，但是包括髕腱/乆繩肌的自體肌腱移植可能會引起相關肌腱供區(qū)的繼發(fā)疾病，包括會引起供區(qū)髕腱炎、肌力減退和髕下脂肪墊攣縮；異體肌腱又存在長入延遲、術后移植物強度減弱、引發(fā)免疫排斥反應和傳播感染性疾病的風險，所以自體或異體肌腱移植帶來的并發(fā)癥幾乎是不可避免的。近年來，國外的外科醫(yī)生普遍認同采用人工韌帶移植重建來恢復關節(jié)運動功能，它已成為應對關節(jié)損傷的常規(guī)手術，而目前國內醫(yī)療市場的人工韌帶醫(yī)療產品均無自主知識產權；通過回顧文獻，我們還發(fā)現國外現有的同類醫(yī)療產品生物相容性較差，仍達不到完美的效果。聚對苯二甲酸乙二醇酯(Polyethylene terephthalate, PET)作為聚酯的代表，完全能滿足人體天然韌帶的力學要求，我們擬通過編織PET纖維構建韌帶支架材料，并分析支架材料力學性能，探討使用該材料構建人工前交叉韌帶支架材料的可行性。 實驗一聚對苯二甲酸乙二醇酯支架材料的空穿編織 目的：通過對聚對苯二甲酸乙二醇酯(Polyethylene terephthalate, PET)材料的編織，構建組織工程韌帶支架材料。方法：使用RSJ4型多梳花邊經編機將不同強度的PET單纖維通過經編法編織，電鏡觀察其內部結構。結果：PET編織構建的支架材料結構穩(wěn)定，適合構建人工韌帶。結論：該支架材料編織結構設計合理，符合人工韌帶支架材料的設計要求。 實驗二人工韌帶支架材料的力學性能評價 目的：通過對聚對苯二甲酸乙二醇酯(Polyethylene terephthalate, PET)材料的力學性能的分析，初步探討使用該材料構建組織工程韌帶支架的可行性。方法：使用電子拉力機（H25KS-S, Hounsfield Test Equipment Ltd, UK）對編織好的支架材料以及消毒處理后的支架材料進行力學性能測試并進行分析。結果：其極限抗張強度等力學指標已滿足了正常人體ACL的生物力學要求。而常規(guī)輻照消毒對此支架材料的力學性能無短期影響。結論：該支架材料具有優(yōu)良的力學性能，消毒后對其力學性能無短期影響，有望通過改進生物學性能后成為一種較理想的組織工程前交叉韌帶支架材料。
[Abstract]:Background: with the development of national strength and the improvement of living standards, sports are becoming more and more popular, and the incidence of joint ligament injury is increasing year by year. It is conservatively estimated that there should be no less than 10 million cases of ligament injury every year. The ligament tissue of the human body is different from the bone tissue. This injury, if left untreated, usually reduces joint stability and secondary damage to other tissue structures, and ultimately leads to serious associated joint motion disorders. There are many methods of ligament reconstruction that have been invented and put into use. There is widespread consensus that autogenous or allogeneic tendon transplants can be reconstructed, but autogenous tendon transplants that include patellar / human hamstring may cause secondary diseases in the associated tendon donor area, including patellar tendinitis in the donor region. Hypotonia and subpatellar fat pad contracture, allogeneic tendon growth delayed, graft strength weakened, immune rejection and the risk of transmission of infectious diseases, In recent years, surgeons abroad generally agree that artificial ligament transplantation is widely used to restore joint motor function, which has become a routine operation to deal with joint injury. At present, the artificial ligament medical products in the domestic medical market do not have independent intellectual property rights. By reviewing the literature, we also find that the biocompatibility of similar medical products in foreign countries is poor. Polyethylene terephthalate (pet), as the representative of polyester, can completely meet the mechanical requirements of human natural ligaments. We intend to construct ligament scaffolds by weaving PET fibers. The mechanical properties of the scaffold were analyzed and the feasibility of using the material to construct the artificial anterior cruciate ligament scaffold was discussed. Experiment 1. Air penetration braiding of polyethylene terephthalate scaffold material. Objective: to construct tissue engineering ligament scaffold material by braiding polyethylene terephthalate (pet) material. Methods: PET single fiber with different strength was woven by warp knitting machine of RSJ4 type multi-comb lace. Results the structure of the scaffold was stable and suitable for the construction of artificial ligament. Conclusion: the braided structure of the scaffold is reasonable and meets the design requirements of artificial ligament scaffold. Evaluation of mechanical properties of artificial ligament scaffold in experiment 2. Objective: to analyze the mechanical properties of polyethylene terephthalate (PET). The feasibility of using this material to construct tissue engineering ligament scaffold was preliminarily discussed. Methods: the mechanical properties of woven scaffold and sterilized scaffold materials were tested by using electronic drawing machine H25KS-S, Hounsfield Test Equipment Ltd. Results: the mechanical indexes such as ultimate tensile strength have met the biomechanical requirements of ACL in normal human body, but routine irradiation disinfection has no short-term effect on the mechanical properties of the scaffold. Conclusion: the scaffold material has a short term effect. With excellent mechanical properties, There is no short-term effect on mechanical properties after disinfection. It is expected to become an ideal scaffold material for anterior cruciate ligament (ACL) by improving biological properties.
【學位授予單位】：第四軍醫(yī)大學
【學位級別】：碩士
【學位授予年份】：2012
【分類號】：R318.08

【共引文獻】

相關期刊論文 前10條

1 王昆;朱蕾;蔡道章;曾春;盧華定;徐國風;郭曉明;黃慧妍;林思明;;生物型人工韌帶的制備及體外檢測[J];解剖學研究;2007年03期

2 劉憲民;王琪;劉松波;杜明昌;劉兵;白夜;;LARS韌帶在超常體重人群前交叉韌帶重建中的應用[J];中國骨與關節(jié)損傷雜志;2011年10期

3 楊家有;;關節(jié)鏡下無內固定物嵌壓固定術治療前交叉韌帶損傷[J];廣西醫(yī)學;2009年05期

4 蔡長儐;楊柳;;組織工程人工韌研究進展[J];重慶醫(yī)學;2012年22期

5 范文斌;趙建寧;;關節(jié)鏡下LARS韌帶與自體乆繩肌腱重建前交叉韌帶的早期臨床療效比較[J];中國骨與關節(jié)損傷雜志;2013年07期

6 RIBEIRO Viviana Pinto;RIBEIRO Ana Soares;SILVA Carla Joana;DUR飴ES Nelson Feio;BONIF嚶CIO Gra

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