本文選題：嗅覺神經(jīng)系統(tǒng)　切入點(diǎn)：球旁細(xì)胞　出處：《浙江大學(xué)》2012年碩士論文　論文類型：學(xué)位論文

【摘要】：研究神經(jīng)系統(tǒng)最直接的方法就是分析感覺神經(jīng)系統(tǒng)的工作機(jī)制。相比其余感覺神經(jīng)系統(tǒng),嗅覺神經(jīng)系統(tǒng)由于結(jié)構(gòu)簡單,已經(jīng)成為人們認(rèn)知神經(jīng)系統(tǒng)、探索腦信息處理機(jī)制以及記憶機(jī)制的良好的切入點(diǎn)。近年來,嗅球球旁細(xì)胞在生物進(jìn)化過程中的演變機(jī)理及其在嗅覺信息編碼中所起的作用正逐漸引起了該研究領(lǐng)域的普遍關(guān)注。從基于仿真建模分析的神經(jīng)信息編碼研究來看,完善的球旁細(xì)胞電生理模型對上述問題的認(rèn)知有著十分重要的作用。 本文首先簡介了嗅覺神經(jīng)系統(tǒng)的解剖結(jié)構(gòu)、主要細(xì)胞類型、嗅覺傳導(dǎo)通路以及嗅覺神經(jīng)系統(tǒng)的電生理特性。隨后,重點(diǎn)闡述了基于球旁細(xì)胞化學(xué)、形態(tài)、離子通道和動(dòng)作電位發(fā)放等不同分類標(biāo)準(zhǔn)的球旁細(xì)胞異質(zhì)性研究的最新進(jìn)展。接著,相應(yīng)地,按照其中鉀離子通道的分類標(biāo)準(zhǔn)和動(dòng)作電位發(fā)放的分類標(biāo)準(zhǔn),分別建立了異質(zhì)性球旁細(xì)胞的電生理模型,分析了這些模型與球旁細(xì)胞異質(zhì)性電生理實(shí)驗(yàn)研究之間存在的問題和缺陷。最后,針對上述問題,結(jié)合作者現(xiàn)有的工作提出了嗅球球旁細(xì)胞電生理、建模以及嗅覺信息編碼等研究工作的未來發(fā)展方向。 本文建立的異質(zhì)性球旁細(xì)胞電生理模型,能夠?yàn)榻⒁粋�(gè)更符合生理實(shí)際的電生理網(wǎng)絡(luò)模型打下良好的基礎(chǔ),從而可以幫助人們進(jìn)一步研究嗅覺信息編碼機(jī)制。
[Abstract]:The most direct way to study the nervous system is to analyze the working mechanism of the sensory nervous system. Compared with the other sensory nervous systems, the olfactory nervous system has become the cognitive nervous system because of its simple structure. Explore the brain information processing mechanism as well as memory mechanism good breakthrough point. In recent years, The mechanism of olfactory bulb cell evolution in biological evolution and its role in olfactory information coding have gradually attracted the attention of this research field. From the point of view of neural information coding based on simulation modeling analysis, The perfect model of electrophysiology plays an important role in the cognition of the above problems. In this paper, the anatomic structure, main cell types, olfactory conduction pathway and electrophysiological characteristics of olfactory nervous system are introduced. Recent advances in the study of the heterogeneity of paracyclic cells in different classification criteria, such as ion channels and action potential release. Accordingly, according to the classification criteria of potassium channel and action potential release, The electrophysiological models of the heterogenous paracyclic cells were established, and the problems and defects between these models and the experimental studies on the heterogeneity of the periglobular cells were analyzed. Finally, in view of the above problems, Combined with the author's existing work, the future development of the research on the electrophysiology, modeling and olfactory information coding of the olfactory bulb cells is proposed. The electrophysiological model established in this paper can lay a good foundation for the establishment of a more realistic electrophysiological network model, which can help people to further study the encoding mechanism of olfactory information.
【學(xué)位授予單位】：浙江大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R318.18

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本文編號：1566949