本文關(guān)鍵詞： 溫度敏感性 水凝膠 控制釋放 甲狀旁腺激素　出處：《吉林大學(xué)》2012年碩士論文　論文類(lèi)型：學(xué)位論文

【摘要】：隨著種植技術(shù)廣泛應(yīng)用于臨床，，種植義齒作為“人類(lèi)的第三副牙齒”已成為更多患者修復(fù)缺失牙的第一選擇。牙槽骨質(zhì)量和剩余牙槽骨體積是決定口腔種植體初期穩(wěn)定性的關(guān)鍵性因素，但較多患者存在種植體周?chē)橇坎蛔愕膯?wèn)題。甲狀旁腺激素1-34（即PTH1-34）優(yōu)異的成骨作用引起了學(xué)者們的廣泛關(guān)注，以往PTH1-34應(yīng)用于促進(jìn)種植體-骨愈合的實(shí)驗(yàn)研究多限于全身間斷、小劑量給藥方式，但是PTH1-34存在著易變性、半衰期短、價(jià)格昂貴等缺陷，因而研制控制其緩釋的載體，并提高其生物利用率顯得極為必要。環(huán)境敏感性高分子水凝膠是智能型水凝膠的一種，能夠?qū)ν饨绱碳ぎa(chǎn)生敏感響應(yīng)。由于溫度與人體生理環(huán)境密切相關(guān)，所以溫度敏感性水凝膠的研究受到了廣泛的關(guān)注。溫度敏感性水凝膠可以隨著環(huán)境溫度的變化改變其自身的親疏水性和凝膠網(wǎng)絡(luò)的尺寸及體積，因而其作為藥物載體時(shí)可隨著溫度的變化控制藥物的釋放速率。目前研究最廣泛的的溫度敏感性水凝膠是以聚N-異丙基丙烯酰胺（PNIPAAm）為溫度敏感性材料的水凝膠，本文以?xún)啥藥в刑继茧p鍵的聚己內(nèi)酯為交聯(lián)劑，N-異丙基丙烯酰胺為單體，通過(guò)自由基共聚合成了一種生物可降解的溫度敏感性水凝膠，并對(duì)其結(jié)構(gòu)進(jìn)行了表征，研究了此水凝膠體系在不同溫度下的溶脹率，并通過(guò)對(duì)透光率的測(cè)試研究了水凝膠體系的溫度響應(yīng)性。另外，以此水凝膠體系作為載體研究了載有PTH1-34的水凝膠在不同溫度下的釋放行為。模擬釋放結(jié)果表明，該水凝膠體系能實(shí)現(xiàn)所載多肽類(lèi)藥物的持續(xù)釋放，可長(zhǎng)達(dá)13天，因而在口腔種植領(lǐng)域有良好的應(yīng)用前景。
[Abstract]:With the wide application of implant technology in clinic. Implant denture as a "third pair of human teeth" has become the first choice for more patients to repair missing teeth. The quality of alveolar bone and the volume of residual alveolar bone are the key factors to determine the initial stability of dental implants. However, more patients have the problem of insufficient bone mass around implants. The excellent osteogenesis of parathyroid hormone 1-34 (PTH1-34) has attracted wide attention of scholars. In the past, the experimental studies of PTH1-34 used to promote implant-bone healing were limited to systemic discontinuity and low dose administration, but PTH1-34 was characterized by variability and short half-life. It is very necessary to develop the carrier to control its slow release and to improve its bioavailability because of its high cost and so on. The environment-sensitive polymer hydrogel is one of the intelligent hydrogels. Can produce sensitive response to external stimuli. Because temperature is closely related to human physiological environment. Therefore, the research of temperature-sensitive hydrogels has been paid more and more attention. Temperature sensitive hydrogels can change their hydrophobicity and the size and volume of gel networks with the change of ambient temperature. Therefore, as a drug carrier, it can control the drug release rate with the change of temperature. At present, the most widely studied thermo-sensitive hydrogel is poly (N-isopropylacrylamide) PNIPAAm. A hydrogel that is a temperature-sensitive material. In this paper, a biodegradable thermo-sensitive hydrogel was prepared by free radical copolymerization of poly (caprolactone) with carbon-carbon double bond as crosslinking agent (N isopropyl acrylamide) as monomer. The structure of the hydrogel system was characterized, the swelling rate of the hydrogel system was studied at different temperatures, and the temperature response of the hydrogel system was studied by measuring the transmittance of the hydrogel system. The hydrogel system was used as the carrier to study the release behavior of the hydrogel containing PTH1-34 at different temperatures. The simulated release results showed that the hydrogel system could realize the sustained release of polypeptide drugs. It can last up to 13 days, so it has a good application prospect in the field of oral implant.
【學(xué)位授予單位】：吉林大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類(lèi)號(hào)】：R318.08


本文編號(hào)：1490780