本文關(guān)鍵詞： 聚合物 宮內(nèi)避孕器 輸卵管 組織工程 生物材料 材料相容性 形狀記憶聚合物 聚乳酸 聚乳酸基形狀記憶材料 避孕 輸卵管避孕器 制備 應(yīng)用特點(diǎn)　出處：《中國組織工程研究》2016年12期 　論文類型：期刊論文

【摘要】：背景:在選用輸卵管避孕節(jié)育器材料時(shí),可以使用形狀記憶聚合物材料,這種新型材料可以在外界溫度影響下發(fā)生一定的形狀變化,還具備良好的生物降解性,對人體安全無害。目的:制備聚乳酸基形狀記憶輸卵管避孕器,并分析其應(yīng)用特點(diǎn)。方法:首先,制備聚乳酸基形狀記憶輸卵管避孕器。將60只雌性新西蘭大白兔隨機(jī)分為2組,每組30只,實(shí)驗(yàn)組在雙側(cè)輸卵管置入聚乳酸基形狀記憶材料避孕器,對照組不置入避孕器。置入后不同時(shí)間點(diǎn)進(jìn)行大體觀察、血液及組織學(xué)檢測。結(jié)果與結(jié)論:(1)大體觀察結(jié)果:置入后4周,避孕器表面光滑并發(fā)生變形,較置入前明顯變粗、變短;置入6周時(shí),避孕器更短更細(xì),部分已見不到避孕器。(2)血液檢測結(jié)果:置入后6周,兩組白細(xì)胞、紅細(xì)胞、血紅蛋白、血小板、肌酐、尿素水平比較差異無顯著性意義。(3)組織學(xué)觀察結(jié)果:置入后4周,實(shí)驗(yàn)組輸卵管黏膜層存在明顯的水腫和充血現(xiàn)象;置入后6周,實(shí)驗(yàn)組輸卵管黏膜層存在極少量的淋巴細(xì)胞浸潤現(xiàn)象,黏膜層水腫和充血現(xiàn)象得到顯著改善。(4)結(jié)果表明,聚乳酸基形狀記憶材料避孕器置入卵管后會發(fā)生形變及降解,置入早期會對輸卵管壁造成一定的壓迫,但未出現(xiàn)細(xì)胞毒性,具有良好的應(yīng)用安全性。
[Abstract]:Background: shape memory polymer material can be used in the selection of fallopian tube contraceptive material. This new material can change shape under the influence of external temperature and has good biodegradability. Objective: to prepare polylactic acid shape memory fallopian tube contraceptive and analyze its application characteristics. Methods: firstly. 60 female New Zealand white rabbits were randomly divided into 2 groups, 30 in each group. The experimental group was placed in bilateral fallopian tubes with PLA-shape memory material contraceptive device. In the control group, the contraceptive device was not inserted. At different time points after implantation, gross observation, blood and histological examination were performed. Results and conclusion: the surface of the contraceptive device was smooth and deformed 4 weeks after implantation. Thicker and shorter than before placement; At 6 weeks, the device was shorter and finer, and some of them could not see the result of blood test. Six weeks after implantation, the white blood cells, red blood cells, hemoglobin, platelets, creatinine were found in both groups. The results of histological observation showed that there was obvious edema and hyperemia in the mucosal layer of fallopian tube in the experimental group 4 weeks after implantation. At 6 weeks after implantation, there was a very small amount of lymphocyte infiltration in the mucosal layer of fallopian tube in the experimental group, and the edema and congestion of the mucosal layer were significantly improved. Polylactic acid shape memory material contraceptive could deform and degrade after placement of oviduct, and early placement would cause compression on oviduct wall, but no cytotoxicity, so it had good safety in application.
【作者單位】： 三亞市人民醫(yī)院婦產(chǎn)科;海南省人民醫(yī)院婦產(chǎn)科;
【分類號】：R318.08;R169.41
【正文快照】： 文章快速閱讀:聚乳酸基形狀記憶輸卵管避孕器的可行性評價(jià)置入后1,4,6周,分別取出實(shí)驗(yàn)組動物輸卵管內(nèi)的聚乳酸基形狀記憶材料避對照組暴露輸卵管后孕器進(jìn)行觀察首先,設(shè)計(jì)、取雌性新直接縫合切口制作符合兔西蘭大白置入后6周,抽取兔耳緣靜脈血液送檢,輸卵管結(jié)構(gòu)兔60只,檢測白細(xì)

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