本文關(guān)鍵詞：HA-g-PDLA與左旋聚乳酸的共混研究　出處：《北京化工大學》2016年碩士論文　論文類型：學位論文

  更多相關(guān)文章： 羥基磷灰石 聚乳酸 界面相容性 立構(gòu)復(fù)合晶 成核劑

【摘要】：羥基磷灰石(HA)在人體某些硬組織(牙齒、骨骼等)中的含量將近七成,是近年來臨床上公認的優(yōu)秀骨替代材料,但強度低、脆性大、易疲勞等缺點導(dǎo)致HA難以單獨作為骨支撐材料,通常選擇將其與聚合物進行共混來提升其機械性能。其中,聚乳酸(PLA)是一種具備優(yōu)良生物相容性和生物可降解性的聚合物,將其與HA共混制備成復(fù)合材料,一方面PLA可以改善HA易碎,韌性低等缺陷,另一方面HA對PLA降解后的酸性產(chǎn)物能起到緩沖的作用。然而HA納米粒子本身易團聚,在PLA中的分散性較差,選擇右旋聚乳酸(PDLA)接枝改性后的HA(HA-g-PDLA)不僅可以有效的改善與PLA的相容性,還可與左旋聚乳酸(PLLA)形成立構(gòu)復(fù)合晶(sc),通過調(diào)控復(fù)合材料的結(jié)晶性能,從而提升HA/PLA復(fù)合材料的機械性能,擁有廣闊的應(yīng)用前景。本課題主要圍繞接枝共聚物HA-g-PDLA與PLLA共混產(chǎn)物的結(jié)晶行為展開了一系列研究,具體工作如下：1、為了改善HA納米粒子在PLLA基質(zhì)中存在分散性較差的缺點,通過開環(huán)聚合的方法成功制備出HA-g-PDLA接枝聚合物。并研究了HA與DLA不同的反應(yīng)投料比與產(chǎn)物接枝率之間的關(guān)系,優(yōu)化了反應(yīng)條件,實驗結(jié)果證明改性后HA在PLLA中的分散情況得到明顯改善；2、研究了HA-g-PDLA與PLLA在不同共混比例下復(fù)合材料的結(jié)晶能力,闡明了復(fù)合材料中HA-g-PDLA的含量變化對PLLA結(jié)晶性能的影響規(guī)律；3、研究對比HA-g-PDLA/PLLA與PLLA、HA/PLLA、PDLA/PLLA、 HA/PDLA/PLLA、HA-g-PLLA/PLLA等五組共混樣品的結(jié)晶行為,實驗結(jié)果表明HA-g-PDLA/PLLA共混產(chǎn)物的結(jié)晶效果最好,分析了產(chǎn)生這種結(jié)果的原因；4、分別以HA和HA-g-PDLA作為PDLA/PLLA共混樣品的添加劑,研究共混產(chǎn)物中不同晶體的結(jié)晶行為,對比并分析了HA和HA-g-PDLA對PLA均聚物晶體和立構(gòu)復(fù)合晶形成的影響,闡釋了HA-g-PDLA/PLLA復(fù)合材料的結(jié)晶機理。
[Abstract]:Hydroxyapatite (HA) in some human hard tissues (teeth, bones, etc.) content of nearly 70%, is clinically recognized in recent years as an excellent bone substitute materials, but low strength, brittle. It is difficult for HA to be used as bone support material alone because of its weakness such as easy fatigue. It is usually chosen to blend it with polymer to improve its mechanical properties. Polylactic acid (PLA) is a kind of polymer with good biocompatibility and biodegradability. It is blended with HA to form composite material. On the one hand, PLA can improve the fragility and toughness of HA. On the other hand, HA can buffer the acidic product after PLA degradation. However, HA nanoparticles are easy to reunite and have poor dispersion in PLA. The modified Ha-HA-g-PDLA can not only improve the compatibility with PLA effectively. The composite crystal can be formed with L-polylactic acid (PLLA), and the mechanical properties of HA/PLA composites can be improved by controlling the crystalline properties of the composites. This paper focuses on the crystallization behavior of graft copolymer (HA-g-PDLA) and PLLA blends. The main work is as follows: 1. In order to improve the dispersion of HA nanoparticles in PLLA matrix, there is a disadvantage of poor dispersion. HA-g-PDLA grafted polymers were successfully prepared by ring-opening polymerization. The relationship between the different feed ratio of HA and DLA and the grafting rate of the product was studied, and the reaction conditions were optimized. The results show that the dispersion of modified HA in PLLA is improved obviously. 2. The crystallinity of HA-g-PDLA / PLLA composites with different blending ratios was studied. The effect of the content of HA-g-PDLA on the crystallization properties of PLLA was clarified. 3. The study compared HA-g-PDLA/PLLA with PLLAA / PA / PLLA / PLLA, HA/PDLA/PLLA. The crystallization behavior of HA-g-PLLA/PLLA and other five groups of blend samples, the experimental results show that the crystallization effect of HA-g-PDLA/PLLA blends is the best. The reasons for this result are analyzed. (4) HA and HA-g-PDLA were used as additives of PDLA/PLLA blends to study the crystallization behavior of different crystals in the blends. The effects of HA and HA-g-PDLA on the formation of PLA homopolymer crystals and orthotropic composite crystals were compared and analyzed, and the crystallization mechanism of HA-g-PDLA/PLLA composites was explained.
【學位授予單位】：北京化工大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：TB332;R318.08

【參考文獻】

相關(guān)期刊論文 前10條

1 劉大海;李開南;魏友華;;生物降解材料復(fù)合成骨因子在骨科應(yīng)用研究中的進展[J];中國組織工程研究;2015年52期

2 夏宇馳;熊成浩;劉煜;;聚乳酸的合成及其修飾的研究進展[J];藥物生物技術(shù);2015年06期

3 董盼盼;徐亞輝;郭雙桃;;多孔羥基磷灰石的制備及其性能研究[J];當代化工;2015年11期

4 方振華;;聚乳酸材料耐熱改性研究進展[J];合成纖維;2015年10期

5 黃國福;孫可;;骨填充材料在骨腫瘤缺損修復(fù)中的應(yīng)用研究進展[J];中國臨床新醫(yī)學;2015年07期

6 陳學思;;綠色塑料聚乳酸的關(guān)鍵技術(shù)研發(fā)與產(chǎn)業(yè)化應(yīng)用[J];科技促進發(fā)展;2015年03期

7 廖建國;李艷群;段星澤;朱伶俐;;納米羥基磷灰石/聚合物復(fù)合骨修復(fù)材料[J];化學進展;2015年Z1期

8 郝妮媛;劉陽;鄒俊;;聚乳酸β晶型的研究進展[J];江蘇科技大學學報(自然科學版);2015年01期

9 李楠;史學濤;張廣成;景占鑫;王建興;;聚乳酸立構(gòu)復(fù)合物的結(jié)晶行為[J];高分子材料科學與工程;2014年08期

10 李瑞端;張建軍;陳建峰;滕巍;李彩霞;王潔欣;;改性聚乳酸-聚乙二醇——多西紫杉醇給藥系統(tǒng)的制備[J];化工學報;2014年06期

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