本文關(guān)鍵詞：神經(jīng)刺激電極的表面修飾方法研究　出處：《湘潭大學(xué)》2016年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 視覺假體 MEMS 微電極 鉑灰 氧化銥

【摘要】：隨著植入式生物醫(yī)療電子技術(shù)的發(fā)展,通過一定尺寸的微電極對人體的特定部位進(jìn)行電刺激,能夠達(dá)到傳統(tǒng)藥物或手術(shù)無法治愈的神經(jīng)損傷性疾病的目的,例如老年性黃斑、面癱以及視網(wǎng)膜色素變性等。但是,神經(jīng)刺激電極在體內(nèi)組織環(huán)境中經(jīng)過長時間會慢慢老化,譬如電極阻抗值劇增和電極表面封裝物脫落導(dǎo)致微電極的有效性以及可靠性變差。通過對微電極進(jìn)行表面修飾可以有效地提高電學(xué)有效性和可靠性,針對微電極的表面修飾工作已經(jīng)成為了近年來的研究熱點。而電鍍作為眾多微電極表面修飾方法中最常用的方法,更是受到國內(nèi)外廣泛關(guān)注。本文首先主要研究了512刺激位點電極的加工工藝方法。然后再針對直徑為200μm的鉑電極進(jìn)行表面修飾,對比分析了單獨電鍍鉑灰、氧化銥以及鉑灰和氧化銥復(fù)合涂層電學(xué)穩(wěn)定性和可靠性。論文的主要結(jié)論如下:(1)為滿足新一代高分辨率人造視網(wǎng)膜的工藝需求,針對柔性視網(wǎng)膜刺激微電極的設(shè)計及制作,研究了512刺激位點的植入式微電極陣列的加工工藝。(2)對直徑200μm的鉑電極進(jìn)行表面修飾。通過Gamry600電化學(xué)工作站,對神經(jīng)刺激微電極進(jìn)行電化學(xué)表面阻抗測試和分析。通過線性電壓掃描和體外循環(huán)伏安法測試確定了微電極適合電鍍的最佳電勢窗口和微電極在體外溶液體系中的穩(wěn)定性。進(jìn)行超聲攪拌實驗,通過觀測實驗中阻抗值的變化可以知道被修飾物與神經(jīng)刺激微電極表面結(jié)合是否穩(wěn)定。而無源加速老化實驗,則可以模擬電極在體內(nèi)一段時間后是否失效,有利于節(jié)約時間和經(jīng)濟(jì)成本。
[Abstract]:With the development of implantable biomedical electronic technology, electrical stimulation of specific parts of human body through a certain size of microelectrode can achieve the purpose of traditional medicine or surgery can not be cured of nerve injury diseases. For example, age-related macula, facial paralysis and retinitis pigmentosa, etc. However, nerve stimulation electrodes in the body over a long period of time in the tissue environment will slowly aging. For example, the increase of electrode impedance and the loss of encapsulation on the electrode surface lead to the deterioration of the validity and reliability of the microelectrode. The surface modification of the microelectrode can effectively improve the electrical efficiency and reliability. Surface modification of microelectrode has become a hot topic in recent years, and electroplating is the most commonly used method in many microelectrode surface modification methods. This paper mainly studied the processing technology of 512 stimulation site electrode. Then the surface modification of platinum electrode with diameter of 200 渭 m was carried out. The platinum ash electroplating was compared and analyzed. The electrical stability and reliability of iridium oxide and platinum ash and iridium oxide composite coatings. Design and fabrication of flexible retinal stimulation microelectrode. The fabrication process of 512-stimulation site implanted microelectrode array was studied. The platinum electrode with a diameter of 200 渭 m was modified by Gamry600 electrochemical workstation. The electrochemical surface impedance of nerve stimulated microelectrode was measured and analyzed. The optimum potential window and microelectrode suitable for electroplating were determined by linear voltage scanning and cardiopulmonary bypass voltammetry. Stability. Ultrasonic stirring experiment was carried out. By observing the change of impedance value in the experiment, we can know whether the surface of the modified electrode and the nerve stimulated microelectrode is stable, while the passive accelerated aging experiment can simulate whether the electrode will fail after a period of time in vivo. It is good for saving time and economic cost.
【學(xué)位授予單位】：湘潭大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：TG174.4;R318.08

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