【摘要】：目的評價特應(yīng)性斑貼試驗(APT)在特應(yīng)性皮炎(AD)患者食物過敏原診斷中的價值,探討不同蛋白濃度過敏原對APT的影響。方法選擇2010年1月-2012年12月本科門診的102例特應(yīng)性皮炎患者進(jìn)行5種常見的食入性過敏原(雞蛋清、牛奶、黃豆、海蝦、小麥)的特應(yīng)性斑貼試驗,同時進(jìn)行這5種過敏原的血清特異性IgE測定及皮膚點(diǎn)刺試驗(SPT),以sIgE作為金標(biāo)準(zhǔn),比較APT與SPT敏感度、特異度及陽性預(yù)測值;并比較3組不同濃度過敏原(1∶5,1∶10,1∶20)APT的結(jié)果。結(jié)果 APT/SPT檢測雞蛋清、牛奶、黃豆、海蝦和小麥的敏感度分別為62.50%/89.58%,71.11%/93.33%,68.42%/84.21%,69.39%/87.76%和85.71%/90.48%;特異度分別為90.74%/96.30%,92.98%/92.98%,95.31%/95.31%,90.57%/92.45%和92.59%/96.30%;陽性預(yù)測值分別為85.71%/86.36%,88.87%/90.30%,89.66%/91.43%,87.18%/91.49%和75.00%/86.36%。另外,其3種不同濃度的陽性率分別為42.16%/34.31%/25.49%,44.12%/35.29%/26.47%,36.27%/28.43%/18.63%,46.08%/38.24%/28.43%和28.43%/23.53%/12.75%,各濃度組間APT陽性率差異均有統(tǒng)計學(xué)意義(P均0.05)。結(jié)論 APT診斷食物過敏原的特異度及陽性預(yù)測值較高,增加過敏原蛋白濃度可提高APT陽性率,反之會降低APT陽性率。
[Abstract]:Objective to evaluate the value of atopic patch test (APT) in the diagnosis of food allergens in patients with atopic dermatitis (AD) and to explore the effect of allergens of different protein concentrations on APT. Methods from January 2010 to December 2012, 102 patients with atopic dermatitis were selected and tested for 5 common allergens (egg white, milk, soybean, prawn, wheat). At the same time, the sensitivity, specificity and positive predictive value of APT and SPT were compared by serum-specific IgE assay and skin prick test (SPT),). SIgE was used as gold standard to compare the sensitivity, specificity and positive predictive value between APT and SPT. The results of three groups with different concentrations of allergens (1? 5, 1? 10, 1? 20) APT were compared. Results the sensitivity of APT/SPT for egg white, milk, soybean, prawn and wheat were 62.50%, 89.58%, 71.11%, 93.33%, 68.42%, 84.21%, respectively. 69.39% / 87.76% and 85.71% / 90.48%; The specificity was 90.74% / 96.30%, 92.98% / 92.98%, 95.31% / 95.31%, 90.57% / 92.45% and 92.59% / 96.30%, respectively. The positive predictive values were 85.71% / 86.36%, 88.87% / 90.30%, 89.66% / 91.43%, 87.18% / 91.49% and 75.0% / 86.36%, respectively. In addition, the positive rates of the three concentrations were 42.16%, 34.31%, 25.49%, 44.12%, 35.29%, 26.47%, 36.27%, 28.43%, 18.63%, respectively. 46.08%, 38.24%, 28.43% and 28.43%, 23.53%, 12.75%, respectively. There was significant difference in the positive rate of APT among different concentration groups (P0.05). Conclusion the specificity and positive predictive value of APT in the diagnosis of food allergens are high. Increasing the concentration of allergen protein can increase the positive rate of APT, and conversely, it will decrease the positive rate of APT.
【作者單位】： 遼寧醫(yī)學(xué)院附屬第一醫(yī)院病理科;遼寧醫(yī)學(xué)院附屬第一醫(yī)院皮膚科;
【基金】：遼寧省醫(yī)學(xué)高峰建設(shè)工程重點(diǎn)科研項目之過敏性疾病�？平ㄔO(shè)項目(200930)
【分類號】：R758.2

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