【摘要】：目的：通過觀察中藥面膜聯(lián)合果酸對尋常性痤瘡皮損的數(shù)量、類型、顏色、腫痛、皮膚油脂含量、皮膚含水量的影響，以探討其臨床療效及作用機制，，為痤瘡的臨床治療提供一種簡單易行，安全有效的方法。方法：將110例尋常性痤瘡患者隨機分為治療組和對照組。治療組給予中藥面膜加果酸治療，果酸治療每4周一次，每次果酸治療一周后給予中藥面膜治療，每周2次，連續(xù)3周中藥面膜。對照組給予果酸治療，果酸治療每4周一次。觀察兩組皮損的變化情況（皮損數(shù)量、類型、顏色、腫痛），并記錄其積分變化。并用COURAGE KHAZAKA公司（CK公司）多功能皮膚檢測儀對患者面部皮膚的油脂含量、含水量進(jìn)行檢測。總療程為3個月，療程結(jié)束后判定療效。結(jié)果：101例患者完成治療。治療組總有效率98.08％，治愈率和顯效率達(dá)90.38％，痊愈率28.85％，對照組總有效率93.88％，治愈率和顯效率達(dá)48.98％，痊愈率8.16％。兩組總有效率比較差異無統(tǒng)計學(xué)意義（P＞0.05），兩組治愈率顯效率之和比較差異有統(tǒng)計學(xué)意義（P＜0.01），兩組痊愈率比較差異有統(tǒng)計學(xué)意義（P＜0.05）。兩組治療后皮膚油脂含量較治療前減少，通過統(tǒng)計學(xué)比較有顯著差異（P＜0.01）。兩組治療后角質(zhì)層含水量較治療前增加，通過統(tǒng)計學(xué)比較有顯著統(tǒng)計學(xué)意義（P＜0.01）。治療后兩組皮膚油脂含量、角質(zhì)層含水量比較有顯著統(tǒng)計學(xué)意義（P＜0.01）。結(jié)論：中藥面膜聯(lián)合果酸治療尋常性痤瘡的臨床療效優(yōu)于單純果酸治療,能減少痤瘡皮膚的油脂含量，提高角質(zhì)層的水分含量，恢復(fù)皮膚屏障功能。該方法可作為治療尋常性痤瘡的一種安全有效的手段，值得在臨床上進(jìn)一步推廣。
[Abstract]:Objective: to observe the effect of traditional Chinese medicine mask combined with pectic acid on the quantity, type, color, swelling and pain of acne vulgaris, the content of oil in skin and the water content of skin, so as to explore the clinical curative effect and the mechanism of action. To provide a simple, safe and effective method for the clinical treatment of acne. Methods: 110 patients with acne vulgaris were randomly divided into treatment group and control group. The patients in the treatment group were treated with traditional Chinese medicine mask and pectic acid every 4 weeks. After one week of treatment, they were treated with the Chinese medicine mask twice a week for 3 weeks. The patients in the treatment group were treated with traditional Chinese medicine facial mask twice a week for 3 weeks. The control group was treated with fruit acid, and the fruit acid treatment was given every 4 weeks. Observe the changes of the lesions (quantity, type, color, swelling and pain) of the two groups and record their integral changes. COURAGE KHAZAKA company (CK company) multi-function skin detector was used to detect the oil content and water content of the patient's facial skin. The total course of treatment was 3 months, and the curative effect was determined after the end of the course. Results: 101 patients completed treatment. The total effective rate of the treatment group was 98.08%, the cure rate and remarkable rate was 90.38%, the cure rate was 28.85%, the total effective rate was 93.88% in the control group, the cure rate and remarkable efficiency was 48.98%, and the cure rate was 8.16%. There was no significant difference in the total effective rate between the two groups (P > 0.05). There was a significant difference in the sum of cure rate between the two groups (P < 0.01), and there was a significant difference in the cure rate between the two groups (P < 0.05). After treatment, the skin fat content in the two groups was lower than that before treatment, and there was a significant difference between the two groups (P < 0.01). After treatment, the water content of the cuticle in the two groups was higher than that before treatment, and there was a significant statistical difference between the two groups (P < 0.01). After treatment, there was significant difference in the content of skin fat and the water content of cuticle between the two groups (P < 0.01). Conclusion: the clinical efficacy of traditional Chinese medicine facial mask combined with pectic acid in treating acne vulgaris is better than that of simple pectic acid treatment. It can reduce the oil content of acne skin, increase the moisture content of cuticle, and restore the skin barrier function. This method can be used as a safe and effective method in the treatment of acne vulgaris.
【學(xué)位授予單位】：瀘州醫(yī)學(xué)院
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R758.733

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